Low Prevalence of TP53 Mutations and MDM2 Amplifications in Pediatric Rhabdomyosarcoma

Low Prevalence of TP53 Mutations and MDM2 Amplifications in Pediatric Rhabdomyosarcoma

The tumor suppressor gene TP53 is the most commonly mutated gene in human cancer. The reported prevalence of mutations in rhabdomyosarcoma (RMS) varies widely, with recent larger studies suggesting that TP53 mutations in pediatric RMS may be extremely rare. Overexpression of MDM2 also attenuates p53...

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Bibliographic Details
Main Authors: Simona Ognjanovic, Ghyslaine Martel, Carlos Manivel, Magali Olivier, Erica Langer, Pierre Hainaut
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Sarcoma
Online Access:http://dx.doi.org/10.1155/2012/492086

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