The Role of Circulating Slit2, the One of the Newly Batokines, in Human Diabetes Mellitus
BackgroundSlit2 is a new secreted protein from adipose tissue that improves glucose hemostasis in mice; however, there is no study about the serum levels and precise role of Slit2 in human. The aim of this study is to explore the serum level of Slit2 in human, and to identify the role of Slit2 in di...
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doaj-00e1c72c7b2f427fad973be641df9ad92020-11-24T22:39:57ZengAcademya Publishing Co.Endocrinology and Metabolism2093-596X2093-59782017-09-0132338338810.3803/EnM.2017.32.3.383The Role of Circulating Slit2, the One of the Newly Batokines, in Human Diabetes MellitusYea Eun Kang0Sorim Choung1Ju Hee Lee2Hyun Jin Kim3Bon Jeong Ku4Department of Endocrinology and Metabolism, Chungnam National University School of Medicine, Daejeon, Korea.Department of Medical Science, Chungnam National University School of Medicine, Daejeon, Korea.Department of Endocrinology and Metabolism, Chungnam National University School of Medicine, Daejeon, Korea.Department of Endocrinology and Metabolism, Chungnam National University School of Medicine, Daejeon, Korea.Department of Endocrinology and Metabolism, Chungnam National University School of Medicine, Daejeon, Korea.BackgroundSlit2 is a new secreted protein from adipose tissue that improves glucose hemostasis in mice; however, there is no study about the serum levels and precise role of Slit2 in human. The aim of this study is to explore the serum level of Slit2 in human, and to identify the role of Slit2 in diabetes mellitus (DM).MethodsThe participants of this study consist of 38 subjects with newly diagnosed DM, and 75 healthy subjects as a control group. Serum Slit2 levels were measured using an enzyme-linked immunosorbent assay. Relationship between circulating Slit2 and diabetic related factors was investigated in diabetic group compared with non-diabetic group. Additionally, the correlations between the serum level of Slit2 and diverse metabolic parameters were analyzed.ResultsCirculating Slit2 level was more decreased in diabetic group than in control group, but there was no significant difference statistically. Interestingly, serum levels of Slit2 were significantly negatively correlated to the serum concentrations of fasting glucose (coefficient r=–0.246, P=0.008), the serum concentrations of postprandial glucose (coefficient r=–0.233, P=0.017), and glycosylated hemoglobin (HbA1c; coefficient r=–0.357, P<0.001).ConclusionFrom our study, the first report of circulating Slit2 levels in human, circulating Slit2 level significantly negatively correlated with serum glucose and HbA1c. Our results suggest that the circulating Slit2 may play a role in maintainence of glucose homeostasis in human, even though exact contribution and mechanism are not yet known.https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-32-383.pdfSlit2BatokineAdipose tissue, brownAdipokinesDiabetes mellitus |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yea Eun Kang Sorim Choung Ju Hee Lee Hyun Jin Kim Bon Jeong Ku |
spellingShingle |
Yea Eun Kang Sorim Choung Ju Hee Lee Hyun Jin Kim Bon Jeong Ku The Role of Circulating Slit2, the One of the Newly Batokines, in Human Diabetes Mellitus Endocrinology and Metabolism Slit2 Batokine Adipose tissue, brown Adipokines Diabetes mellitus |
author_facet |
Yea Eun Kang Sorim Choung Ju Hee Lee Hyun Jin Kim Bon Jeong Ku |
author_sort |
Yea Eun Kang |
title |
The Role of Circulating Slit2, the One of the Newly Batokines, in Human Diabetes Mellitus |
title_short |
The Role of Circulating Slit2, the One of the Newly Batokines, in Human Diabetes Mellitus |
title_full |
The Role of Circulating Slit2, the One of the Newly Batokines, in Human Diabetes Mellitus |
title_fullStr |
The Role of Circulating Slit2, the One of the Newly Batokines, in Human Diabetes Mellitus |
title_full_unstemmed |
The Role of Circulating Slit2, the One of the Newly Batokines, in Human Diabetes Mellitus |
title_sort |
role of circulating slit2, the one of the newly batokines, in human diabetes mellitus |
publisher |
Academya Publishing Co. |
series |
Endocrinology and Metabolism |
issn |
2093-596X 2093-5978 |
publishDate |
2017-09-01 |
description |
BackgroundSlit2 is a new secreted protein from adipose tissue that improves glucose hemostasis in mice; however, there is no study about the serum levels and precise role of Slit2 in human. The aim of this study is to explore the serum level of Slit2 in human, and to identify the role of Slit2 in diabetes mellitus (DM).MethodsThe participants of this study consist of 38 subjects with newly diagnosed DM, and 75 healthy subjects as a control group. Serum Slit2 levels were measured using an enzyme-linked immunosorbent assay. Relationship between circulating Slit2 and diabetic related factors was investigated in diabetic group compared with non-diabetic group. Additionally, the correlations between the serum level of Slit2 and diverse metabolic parameters were analyzed.ResultsCirculating Slit2 level was more decreased in diabetic group than in control group, but there was no significant difference statistically. Interestingly, serum levels of Slit2 were significantly negatively correlated to the serum concentrations of fasting glucose (coefficient r=–0.246, P=0.008), the serum concentrations of postprandial glucose (coefficient r=–0.233, P=0.017), and glycosylated hemoglobin (HbA1c; coefficient r=–0.357, P<0.001).ConclusionFrom our study, the first report of circulating Slit2 levels in human, circulating Slit2 level significantly negatively correlated with serum glucose and HbA1c. Our results suggest that the circulating Slit2 may play a role in maintainence of glucose homeostasis in human, even though exact contribution and mechanism are not yet known. |
topic |
Slit2 Batokine Adipose tissue, brown Adipokines Diabetes mellitus |
url |
https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-32-383.pdf |
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