Relationship of plasma proadrenomedullin and cortisol levels with systemic inflammatory response and target organ damage in children with sepsis after burn
Objective: To study the relationship of plasma proadrenomedullin (pro-ADM) and cortisol (Cor) levels with systemic inflammatory response and target organ damage in children with sepsis after burn. Methods: A total of 30 children with sepsis after burn who were treated in the hospital between Augu...
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doaj-00f23626ede54d3ca71858b99a8148462020-11-24T22:44:30ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12371007-12372017-08-012315129132Relationship of plasma proadrenomedullin and cortisol levels with systemic inflammatory response and target organ damage in children with sepsis after burnXing Wei0Jie Ou-Yang1Chen Zhou2Anesthesiology Department, the Second Affiliated Hospital of Kunming Medical University in Yunnan Province, Kunming City, Yunnan Province, 650101, ChinaAnesthesiology Department, the Second Affiliated Hospital of Kunming Medical University in Yunnan Province, Kunming City, Yunnan Province, 650101, ChinaAnesthesiology Department, the Second Affiliated Hospital of Kunming Medical University in Yunnan Province, Kunming City, Yunnan Province, 650101, ChinaObjective: To study the relationship of plasma proadrenomedullin (pro-ADM) and cortisol (Cor) levels with systemic inflammatory response and target organ damage in children with sepsis after burn. Methods: A total of 30 children with sepsis after burn who were treated in the hospital between August 2014 and August 2016 were collected as observation group, and 30 normal children who received vaccination in the hospital during the same period were collected as normal control group. The pro-ADM and Cor levels in plasma as well as the levels of inflammatory factors, myocardial injury markers and intestinal barrier function indexes in serum of the two groups were determined. Pearson test was used to assess the correlation of plasma pro-ADM and Cor levels with systemic inflammatory response and target organ damage in patients with sepsis after burn. Results: Plasma pro-ADM and Cor levels in observation group were higher than those in normal control group. Serum inflammatory cytokines IL-1, IL-6, IL-10 and TNF-α levels in observation group were higher than those in normal control group; serum myocardial injury markers CK-MB, cTnⅠ and NT-proBNP levels were higher than those in normal control group; serum intestinal barrier function indexes ET, DAO and D-L levels were higher than those in normal control group. Conclusion: Plasma pro-ADM and Cor levels increase in patients with sepsis after burn, and are highly consistent with systemic inflammatory response and target organ injury.http://www.hnykdxxb.com/PDF/201715/31.pdfSepsisProadrenomedullinCortisolSystemic inflammatory responseSystemic inflammatory response Target organ injury |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xing Wei Jie Ou-Yang Chen Zhou |
spellingShingle |
Xing Wei Jie Ou-Yang Chen Zhou Relationship of plasma proadrenomedullin and cortisol levels with systemic inflammatory response and target organ damage in children with sepsis after burn Journal of Hainan Medical University Sepsis Proadrenomedullin Cortisol Systemic inflammatory response Systemic inflammatory response Target organ injury |
author_facet |
Xing Wei Jie Ou-Yang Chen Zhou |
author_sort |
Xing Wei |
title |
Relationship of plasma proadrenomedullin and cortisol levels with systemic inflammatory response and target organ damage in children with sepsis after burn |
title_short |
Relationship of plasma proadrenomedullin and cortisol levels with systemic inflammatory response and target organ damage in children with sepsis after burn |
title_full |
Relationship of plasma proadrenomedullin and cortisol levels with systemic inflammatory response and target organ damage in children with sepsis after burn |
title_fullStr |
Relationship of plasma proadrenomedullin and cortisol levels with systemic inflammatory response and target organ damage in children with sepsis after burn |
title_full_unstemmed |
Relationship of plasma proadrenomedullin and cortisol levels with systemic inflammatory response and target organ damage in children with sepsis after burn |
title_sort |
relationship of plasma proadrenomedullin and cortisol levels with systemic inflammatory response and target organ damage in children with sepsis after burn |
publisher |
Editorial Board of Journal of Hainan Medical University |
series |
Journal of Hainan Medical University |
issn |
1007-1237 1007-1237 |
publishDate |
2017-08-01 |
description |
Objective: To study the relationship of plasma proadrenomedullin (pro-ADM) and cortisol
(Cor) levels with systemic inflammatory response and target organ damage in children with
sepsis after burn. Methods: A total of 30 children with sepsis after burn who were treated
in the hospital between August 2014 and August 2016 were collected as observation group,
and 30 normal children who received vaccination in the hospital during the same period were
collected as normal control group. The pro-ADM and Cor levels in plasma as well as the levels
of inflammatory factors, myocardial injury markers and intestinal barrier function indexes
in serum of the two groups were determined. Pearson test was used to assess the correlation
of plasma pro-ADM and Cor levels with systemic inflammatory response and target organ
damage in patients with sepsis after burn. Results: Plasma pro-ADM and Cor levels in
observation group were higher than those in normal control group. Serum inflammatory
cytokines IL-1, IL-6, IL-10 and TNF-α levels in observation group were higher than those
in normal control group; serum myocardial injury markers CK-MB, cTnⅠ and NT-proBNP
levels were higher than those in normal control group; serum intestinal barrier function indexes
ET, DAO and D-L levels were higher than those in normal control group. Conclusion: Plasma
pro-ADM and Cor levels increase in patients with sepsis after burn, and are highly consistent
with systemic inflammatory response and target organ injury. |
topic |
Sepsis Proadrenomedullin Cortisol Systemic inflammatory response Systemic inflammatory response Target organ injury |
url |
http://www.hnykdxxb.com/PDF/201715/31.pdf |
work_keys_str_mv |
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