Re-Setting the Circadian Clock Using Exercise against Sarcopenia
Sarcopenia is defined as the involuntary loss of skeletal muscle mass and function with aging and is associated with several adverse health outcomes. Recently, the disruption of regular circadian rhythms, due to shift work or nocturnal lifestyle, is emerging as a novel deleterious factor for the dev...
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doaj-0106bf7d18cf438dbb691d78c84bc4362020-11-25T02:36:29ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-04-01213106310610.3390/ijms21093106Re-Setting the Circadian Clock Using Exercise against SarcopeniaYoungju Choi0Jinkyung Cho1Mi-Hyun No2Jun-Won Heo3Eun-Jeong Cho4Eunwook Chang5Dong-Ho Park6Ju-Hee Kang7Hyo-Bum Kwak8Institute of Sports & Arts Convergence (ISAC), Inha University, Incheon 22212, KoreaInstitute of Sports & Arts Convergence (ISAC), Inha University, Incheon 22212, KoreaDepartment of Kinesiology, Inha University, Incheon 22212, KoreaInstitute of Sports & Arts Convergence (ISAC), Inha University, Incheon 22212, KoreaInstitute of Sports & Arts Convergence (ISAC), Inha University, Incheon 22212, KoreaInstitute of Sports & Arts Convergence (ISAC), Inha University, Incheon 22212, KoreaInstitute of Sports & Arts Convergence (ISAC), Inha University, Incheon 22212, KoreaInstitute of Sports & Arts Convergence (ISAC), Inha University, Incheon 22212, KoreaInstitute of Sports & Arts Convergence (ISAC), Inha University, Incheon 22212, KoreaSarcopenia is defined as the involuntary loss of skeletal muscle mass and function with aging and is associated with several adverse health outcomes. Recently, the disruption of regular circadian rhythms, due to shift work or nocturnal lifestyle, is emerging as a novel deleterious factor for the development of sarcopenia. The underlying mechanisms responsible for circadian disruption-induced sarcopenia include molecular circadian clock and mitochondrial function associated with the regulation of circadian rhythms. Exercise is a potent modulator of skeletal muscle metabolism and is considered to be a crucial preventative and therapeutic intervention strategy for sarcopenia. Moreover, emerging evidence shows that exercise, acting as a zeitgeber (time cue) of the skeletal muscle clock, can be an efficacious tool for re-setting the clock in sarcopenia. In this review, we provide the evidence of the impact of circadian disruption on skeletal muscle loss resulting in sarcopenia. Furthermore, we highlight the importance of exercise timing (i.e., scheduled physical activity) as a novel therapeutic strategy to target circadian disruption in skeletal muscle.https://www.mdpi.com/1422-0067/21/9/3106circadian rhythmsarcopeniaexercisemitochondrial functionskeletal muscle |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Youngju Choi Jinkyung Cho Mi-Hyun No Jun-Won Heo Eun-Jeong Cho Eunwook Chang Dong-Ho Park Ju-Hee Kang Hyo-Bum Kwak |
spellingShingle |
Youngju Choi Jinkyung Cho Mi-Hyun No Jun-Won Heo Eun-Jeong Cho Eunwook Chang Dong-Ho Park Ju-Hee Kang Hyo-Bum Kwak Re-Setting the Circadian Clock Using Exercise against Sarcopenia International Journal of Molecular Sciences circadian rhythm sarcopenia exercise mitochondrial function skeletal muscle |
author_facet |
Youngju Choi Jinkyung Cho Mi-Hyun No Jun-Won Heo Eun-Jeong Cho Eunwook Chang Dong-Ho Park Ju-Hee Kang Hyo-Bum Kwak |
author_sort |
Youngju Choi |
title |
Re-Setting the Circadian Clock Using Exercise against Sarcopenia |
title_short |
Re-Setting the Circadian Clock Using Exercise against Sarcopenia |
title_full |
Re-Setting the Circadian Clock Using Exercise against Sarcopenia |
title_fullStr |
Re-Setting the Circadian Clock Using Exercise against Sarcopenia |
title_full_unstemmed |
Re-Setting the Circadian Clock Using Exercise against Sarcopenia |
title_sort |
re-setting the circadian clock using exercise against sarcopenia |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2020-04-01 |
description |
Sarcopenia is defined as the involuntary loss of skeletal muscle mass and function with aging and is associated with several adverse health outcomes. Recently, the disruption of regular circadian rhythms, due to shift work or nocturnal lifestyle, is emerging as a novel deleterious factor for the development of sarcopenia. The underlying mechanisms responsible for circadian disruption-induced sarcopenia include molecular circadian clock and mitochondrial function associated with the regulation of circadian rhythms. Exercise is a potent modulator of skeletal muscle metabolism and is considered to be a crucial preventative and therapeutic intervention strategy for sarcopenia. Moreover, emerging evidence shows that exercise, acting as a zeitgeber (time cue) of the skeletal muscle clock, can be an efficacious tool for re-setting the clock in sarcopenia. In this review, we provide the evidence of the impact of circadian disruption on skeletal muscle loss resulting in sarcopenia. Furthermore, we highlight the importance of exercise timing (i.e., scheduled physical activity) as a novel therapeutic strategy to target circadian disruption in skeletal muscle. |
topic |
circadian rhythm sarcopenia exercise mitochondrial function skeletal muscle |
url |
https://www.mdpi.com/1422-0067/21/9/3106 |
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