Middle cerebral artery velocity dynamic response profile during exercise is attenuated following multiple ischemic strokes: a case report
Abstract Blood flow regulation is impaired in people with stroke. However, the time course of change in middle cerebral artery velocity (MCAv) following repeated stroke at rest and during exercise remains unknown. In this case study, we provide novel characterization of the dynamic kinetic MCAv resp...
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doaj-010df84ba5ca4ac698c73da0f30d8f892020-11-25T03:21:40ZengWileyPhysiological Reports2051-817X2019-11-01721n/an/a10.14814/phy2.14268Middle cerebral artery velocity dynamic response profile during exercise is attenuated following multiple ischemic strokes: a case reportCarolyn S. Kaufman0Stephen X. Bai1Jaimie L. Ward2Sarah M. Eickmeyer3Sandra A. Billinger4Department of Molecular and Integrative Physiology University of Kansas Medical Center Kansas City KansasDepartment of Physical Medicine and Rehabilitation University of Kansas Medical Center Kansas City KansasDepartment of Physical Therapy and Rehabilitation Science University of Kansas Medical Center Kansas City KansasDepartment of Physical Medicine and Rehabilitation University of Kansas Medical Center Kansas City KansasDepartment of Molecular and Integrative Physiology University of Kansas Medical Center Kansas City KansasAbstract Blood flow regulation is impaired in people with stroke. However, the time course of change in middle cerebral artery velocity (MCAv) following repeated stroke at rest and during exercise remains unknown. In this case study, we provide novel characterization of the dynamic kinetic MCAv response profile to moderate‐intensity exercise before and after repeated ischemic MCA stroke. The initial stroke occurred in the left MCA. At 3 months poststroke, left MCAv amplitude (Amp) was ~50% lower than the right. At the 6‐month follow‐up visit, MCAv Amp declined in both MCA with the left MCAv Amp ~50% lower than the right MCAv Amp. Following a second right MCA stroke, we report further decline in Amp for the left MCA. At the 3‐ and 6‐month visit following the second stroke, the left MCAv Amp declined further (~10%). The right MCAv Amp dramatically decreased by 81.3% when compared to the initial study visit. The MCAv kinetic analysis revealed a marked impairment in the cerebrovascular response to exercise following stroke. We discuss potential pathophysiological mechanisms contributing to poststroke cerebrovascular dysfunction and the need to test therapeutic interventions (such as exercise) that might attenuate cerebrovascular decline in people following stroke.https://doi.org/10.14814/phy2.14268Cerebrovascularexercisestrokeultrasound |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Carolyn S. Kaufman Stephen X. Bai Jaimie L. Ward Sarah M. Eickmeyer Sandra A. Billinger |
spellingShingle |
Carolyn S. Kaufman Stephen X. Bai Jaimie L. Ward Sarah M. Eickmeyer Sandra A. Billinger Middle cerebral artery velocity dynamic response profile during exercise is attenuated following multiple ischemic strokes: a case report Physiological Reports Cerebrovascular exercise stroke ultrasound |
author_facet |
Carolyn S. Kaufman Stephen X. Bai Jaimie L. Ward Sarah M. Eickmeyer Sandra A. Billinger |
author_sort |
Carolyn S. Kaufman |
title |
Middle cerebral artery velocity dynamic response profile during exercise is attenuated following multiple ischemic strokes: a case report |
title_short |
Middle cerebral artery velocity dynamic response profile during exercise is attenuated following multiple ischemic strokes: a case report |
title_full |
Middle cerebral artery velocity dynamic response profile during exercise is attenuated following multiple ischemic strokes: a case report |
title_fullStr |
Middle cerebral artery velocity dynamic response profile during exercise is attenuated following multiple ischemic strokes: a case report |
title_full_unstemmed |
Middle cerebral artery velocity dynamic response profile during exercise is attenuated following multiple ischemic strokes: a case report |
title_sort |
middle cerebral artery velocity dynamic response profile during exercise is attenuated following multiple ischemic strokes: a case report |
publisher |
Wiley |
series |
Physiological Reports |
issn |
2051-817X |
publishDate |
2019-11-01 |
description |
Abstract Blood flow regulation is impaired in people with stroke. However, the time course of change in middle cerebral artery velocity (MCAv) following repeated stroke at rest and during exercise remains unknown. In this case study, we provide novel characterization of the dynamic kinetic MCAv response profile to moderate‐intensity exercise before and after repeated ischemic MCA stroke. The initial stroke occurred in the left MCA. At 3 months poststroke, left MCAv amplitude (Amp) was ~50% lower than the right. At the 6‐month follow‐up visit, MCAv Amp declined in both MCA with the left MCAv Amp ~50% lower than the right MCAv Amp. Following a second right MCA stroke, we report further decline in Amp for the left MCA. At the 3‐ and 6‐month visit following the second stroke, the left MCAv Amp declined further (~10%). The right MCAv Amp dramatically decreased by 81.3% when compared to the initial study visit. The MCAv kinetic analysis revealed a marked impairment in the cerebrovascular response to exercise following stroke. We discuss potential pathophysiological mechanisms contributing to poststroke cerebrovascular dysfunction and the need to test therapeutic interventions (such as exercise) that might attenuate cerebrovascular decline in people following stroke. |
topic |
Cerebrovascular exercise stroke ultrasound |
url |
https://doi.org/10.14814/phy2.14268 |
work_keys_str_mv |
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