Membrane cholesterol regulates lysosome-plasma membrane fusion events and modulates Trypanosoma cruzi invasion of host cells.

Membrane cholesterol regulates lysosome-plasma membrane fusion events and modulates Trypanosoma cruzi invasion of host cells.

BACKGROUND: Trypomastigotes of Trypanosoma cruzi are able to invade several types of non-phagocytic cells through a lysosomal dependent mechanism. It has been shown that, during invasion, parasites trigger host cell lysosome exocytosis, which initially occurs at the parasite-host contact site. Acid...

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Main Authors: Bárbara Hissa, Jacqueline G Duarte, Ludmila F Kelles, Fabio P Santos, Helen L del Puerto, Pedro H Gazzinelli-Guimarães, Ana M de Paula, Ubirajara Agero, Oscar N Mesquita, Cristina Guatimosim, Egler Chiari, Luciana O Andrade
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3313932?pdf=render

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