Engineering prokaryotic channels for control of mammalian tissue excitability

Engineering prokaryotic channels for control of mammalian tissue excitability

Restoring lost excitability of injured tissue is a paramount of regenerative medicine. By using a combined expression of bacterial voltage-gated Na+ channel, Kir2.1, and connexin-43 in non-excitable human fibroblasts, here the authors generate excitable cells that rescue action potential conduction...

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Main Authors: Hung X. Nguyen, Robert D. Kirkton, Nenad Bursac
Format: Article
Language:English
Published: Nature Publishing Group 2016-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13132
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spelling doaj-01169a26b7fb41869b421987bafb38d42021-05-11T10:45:38ZengNature Publishing GroupNature Communications2041-17232016-10-017111110.1038/ncomms13132Engineering prokaryotic channels for control of mammalian tissue excitabilityHung X. Nguyen0Robert D. Kirkton1Nenad Bursac2Department of Biomedical Engineering, Duke UniversityDepartment of Biomedical Engineering, Duke UniversityDepartment of Biomedical Engineering, Duke UniversityRestoring lost excitability of injured tissue is a paramount of regenerative medicine. By using a combined expression of bacterial voltage-gated Na+ channel, Kir2.1, and connexin-43 in non-excitable human fibroblasts, here the authors generate excitable cells that rescue action potential conduction in an in vitromodel of cardiac fibrosis.https://doi.org/10.1038/ncomms13132
collection DOAJ
language English
format Article
sources DOAJ
author Hung X. Nguyen
Robert D. Kirkton
Nenad Bursac
spellingShingle Hung X. Nguyen
Robert D. Kirkton
Nenad Bursac
Engineering prokaryotic channels for control of mammalian tissue excitability
Nature Communications
author_facet Hung X. Nguyen
Robert D. Kirkton
Nenad Bursac
author_sort Hung X. Nguyen
title Engineering prokaryotic channels for control of mammalian tissue excitability
title_short Engineering prokaryotic channels for control of mammalian tissue excitability
title_full Engineering prokaryotic channels for control of mammalian tissue excitability
title_fullStr Engineering prokaryotic channels for control of mammalian tissue excitability
title_full_unstemmed Engineering prokaryotic channels for control of mammalian tissue excitability
title_sort engineering prokaryotic channels for control of mammalian tissue excitability
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-10-01
description Restoring lost excitability of injured tissue is a paramount of regenerative medicine. By using a combined expression of bacterial voltage-gated Na+ channel, Kir2.1, and connexin-43 in non-excitable human fibroblasts, here the authors generate excitable cells that rescue action potential conduction in an in vitromodel of cardiac fibrosis.
url https://doi.org/10.1038/ncomms13132
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AT robertdkirkton engineeringprokaryoticchannelsforcontrolofmammaliantissueexcitability
AT nenadbursac engineeringprokaryoticchannelsforcontrolofmammaliantissueexcitability
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