Dopamine Receptor Subtypes, Physiology and Pharmacology: New Ligands and Concepts in Schizophrenia
Dopamine receptors are widely distributed within the brain where they play critical modulator roles on motor functions, motivation and drive, as well as cognition. The identification of five genes coding for different dopamine receptor subtypes, pharmacologically grouped as D1- (D1 and D5) or D2-lik...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-07-01
|
Series: | Frontiers in Pharmacology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2020.01003/full |
id |
doaj-0119af13cf0a40ac815eccf9c91c8e12 |
---|---|
record_format |
Article |
spelling |
doaj-0119af13cf0a40ac815eccf9c91c8e122020-11-25T03:24:42ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122020-07-011110.3389/fphar.2020.01003557887Dopamine Receptor Subtypes, Physiology and Pharmacology: New Ligands and Concepts in SchizophreniaJean Claude Martel0Silvia Gatti McArthur1Independent Researcher, Amos, QC, CanadaMcArthur and Associates, Basel, SwitzerlandDopamine receptors are widely distributed within the brain where they play critical modulator roles on motor functions, motivation and drive, as well as cognition. The identification of five genes coding for different dopamine receptor subtypes, pharmacologically grouped as D1- (D1 and D5) or D2-like (D2S, D2L, D3, and D4) has allowed the demonstration of differential receptor function in specific neurocircuits. Recent observation on dopamine receptor signaling point at dopamine—glutamate-NMDA neurobiology as the most relevant in schizophrenia and for the development of new therapies. Progress in the chemistry of D1- and D2-like receptor ligands (agonists, antagonists, and partial agonists) has provided more selective compounds possibly able to target the dopamine receptors homo and heterodimers and address different schizophrenia symptoms. Moreover, an extensive evaluation of the functional effect of these agents on dopamine receptor coupling and intracellular signaling highlights important differences that could also result in highly differentiated clinical pharmacology. The review summarizes the recent advances in the field, addressing the relevance of emerging new targets in schizophrenia in particular in relation to the dopamine – glutamate NMDA systems interactions.https://www.frontiersin.org/article/10.3389/fphar.2020.01003/fullschizophreniadopamine receptorNMDAantipsychoticpsychosisD1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jean Claude Martel Silvia Gatti McArthur |
spellingShingle |
Jean Claude Martel Silvia Gatti McArthur Dopamine Receptor Subtypes, Physiology and Pharmacology: New Ligands and Concepts in Schizophrenia Frontiers in Pharmacology schizophrenia dopamine receptor NMDA antipsychotic psychosis D1 |
author_facet |
Jean Claude Martel Silvia Gatti McArthur |
author_sort |
Jean Claude Martel |
title |
Dopamine Receptor Subtypes, Physiology and Pharmacology: New Ligands and Concepts in Schizophrenia |
title_short |
Dopamine Receptor Subtypes, Physiology and Pharmacology: New Ligands and Concepts in Schizophrenia |
title_full |
Dopamine Receptor Subtypes, Physiology and Pharmacology: New Ligands and Concepts in Schizophrenia |
title_fullStr |
Dopamine Receptor Subtypes, Physiology and Pharmacology: New Ligands and Concepts in Schizophrenia |
title_full_unstemmed |
Dopamine Receptor Subtypes, Physiology and Pharmacology: New Ligands and Concepts in Schizophrenia |
title_sort |
dopamine receptor subtypes, physiology and pharmacology: new ligands and concepts in schizophrenia |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pharmacology |
issn |
1663-9812 |
publishDate |
2020-07-01 |
description |
Dopamine receptors are widely distributed within the brain where they play critical modulator roles on motor functions, motivation and drive, as well as cognition. The identification of five genes coding for different dopamine receptor subtypes, pharmacologically grouped as D1- (D1 and D5) or D2-like (D2S, D2L, D3, and D4) has allowed the demonstration of differential receptor function in specific neurocircuits. Recent observation on dopamine receptor signaling point at dopamine—glutamate-NMDA neurobiology as the most relevant in schizophrenia and for the development of new therapies. Progress in the chemistry of D1- and D2-like receptor ligands (agonists, antagonists, and partial agonists) has provided more selective compounds possibly able to target the dopamine receptors homo and heterodimers and address different schizophrenia symptoms. Moreover, an extensive evaluation of the functional effect of these agents on dopamine receptor coupling and intracellular signaling highlights important differences that could also result in highly differentiated clinical pharmacology. The review summarizes the recent advances in the field, addressing the relevance of emerging new targets in schizophrenia in particular in relation to the dopamine – glutamate NMDA systems interactions. |
topic |
schizophrenia dopamine receptor NMDA antipsychotic psychosis D1 |
url |
https://www.frontiersin.org/article/10.3389/fphar.2020.01003/full |
work_keys_str_mv |
AT jeanclaudemartel dopaminereceptorsubtypesphysiologyandpharmacologynewligandsandconceptsinschizophrenia AT silviagattimcarthur dopaminereceptorsubtypesphysiologyandpharmacologynewligandsandconceptsinschizophrenia |
_version_ |
1724600452581949440 |