The Mechanisms of Nuclear Proteotoxicity in Polyglutamine Spinocerebellar Ataxias

The Mechanisms of Nuclear Proteotoxicity in Polyglutamine Spinocerebellar Ataxias

Polyglutamine (polyQ) spinocerebellar ataxias (SCAs) are the most prevalent subset of SCAs and share the aberrant expansion of Q-encoding CAG repeats within the coding sequences of disease-responsible genes as their common genetic cause. These polyQ SCAs (SCA1, SCA2, SCA3, SCA6, SCA7, and SCA17) are...

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Bibliographic Details
Main Authors: Davin Lee, Yun-Il Lee, Young-Sam Lee, Sung Bae Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Neuroscience
Subjects:
polyQ SCAs
CAG repeat expansion
repeat instability
nuclear translocation
nuclear proteotoxicity
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00489/full

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