Targeting Cancer Stem Cells with Differentiation Agents as an Alternative to Genotoxic Chemotherapy for the Treatment of Malignant Testicular Germ Cell Tumors

Targeting Cancer Stem Cells with Differentiation Agents as an Alternative to Genotoxic Chemotherapy for the Treatment of Malignant Testicular Germ Cell Tumors

Testicular germ cell tumors (TGCTs) are exceptionally sensitive to genotoxic chemotherapy, resulting in a high cure rate for the young men presenting with these malignancies. However, this treatment is associated with significant toxicity, and a subset of malignant TGCTs demonstrate chemoresistance....

Full description

Bibliographic Details
Main Authors: Amanda R. Loehr, Timothy M. Pierpont, Eric Gelsleichter, Anabella Maria D. Galang, Irma R. Fernandez, Elizabeth S. Moore, Matthew Z. Guo, Andrew D. Miller, Robert S. Weiss
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
testicular germ cell tumor
embryonal carcinoma
nonseminoma
differentiation therapy
thioridazine
cancer stem cells
Online Access:https://www.mdpi.com/2072-6694/13/9/2045

Similar Items

Similar Items