Comparative Study of Novel Noninvasive Cerebral Autoregulation Volumetric Reactivity Indices Reflected by Ultrasonic Speed and Attenuation as Dynamic Measurements in the Human Brain
This is a comparative study of two novel noninvasive cerebrovascular autoregulation (CA) monitoring methods based on intracranial blood volume (IBV) changes in the human brain. We investigated the clinical applicability of the new volumetric reactivity index (VRx2), reflected by intracranial ultraso...
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doaj-0121143163e144a7b49a5448ac4d3ed22020-11-25T02:37:26ZengMDPI AGBrain Sciences2076-34252020-04-011020520510.3390/brainsci10040205Comparative Study of Novel Noninvasive Cerebral Autoregulation Volumetric Reactivity Indices Reflected by Ultrasonic Speed and Attenuation as Dynamic Measurements in the Human BrainBasant K. Bajpai0Rolandas Zakelis1Mantas Deimantavicius2Daiva Imbrasiene3Health Telematics Science Institute, Kaunas University of Technology, LT-51423 Kaunas, LithuaniaHealth Telematics Science Institute, Kaunas University of Technology, LT-51423 Kaunas, LithuaniaHealth Telematics Science Institute, Kaunas University of Technology, LT-51423 Kaunas, LithuaniaDepartment of Health Promotion and Rehabilitation, Lithuanian Sports University, LT-44221 Kaunas, LithuaniaThis is a comparative study of two novel noninvasive cerebrovascular autoregulation (CA) monitoring methods based on intracranial blood volume (IBV) changes in the human brain. We investigated the clinical applicability of the new volumetric reactivity index (VRx2), reflected by intracranial ultrasonic attenuation dynamics for noninvasive CA monitoring. The CA was determined noninvasively on 43 healthy participants by calculating the volumetric reactivity index (VRx1 from time-of-flight of ultrasound, VRx2 from attenuation of ultrasound). The VRx was calculated as a moving correlation coefficient between the arterial blood pressure and noninvasively measured IBV slow waves. Linear regression between VRx1 and VRx2 (averaged per participants) showed a significant correlation (<i>r</i> = 0.731, <i>p</i> < 0.0001, 95% confidence interval [0.501–0.895]) in data filtered by bandpass filtering. On the other hand, FIR filtering demonstrated a slightly better correlation (<i>r</i> = 0.769, <i>p</i> < 0.0001, 95% confidence interval [0.611–0.909]). The standard deviation of the difference by bandpass filtering was 0.1647 and bias −0.3444; and by FIR filtering 0.1382 and bias −0.3669. This comparative study showed a significant coincidence of the VRx2 index compared to that of VRx1. Hence, VRx2 could be used as an alternative, cost-effective noninvasive cerebrovascular autoregulation index in the same way as VRx1 values are used.https://www.mdpi.com/2076-3425/10/4/205ABP = arterial blood pressureCPP = cerebral perfusion pressureCA = cerebrovascular autoregulationICP = intracranial pressurePRx = pressure reactivity indexCBF = cerebral blood flow |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Basant K. Bajpai Rolandas Zakelis Mantas Deimantavicius Daiva Imbrasiene |
spellingShingle |
Basant K. Bajpai Rolandas Zakelis Mantas Deimantavicius Daiva Imbrasiene Comparative Study of Novel Noninvasive Cerebral Autoregulation Volumetric Reactivity Indices Reflected by Ultrasonic Speed and Attenuation as Dynamic Measurements in the Human Brain Brain Sciences ABP = arterial blood pressure CPP = cerebral perfusion pressure CA = cerebrovascular autoregulation ICP = intracranial pressure PRx = pressure reactivity index CBF = cerebral blood flow |
author_facet |
Basant K. Bajpai Rolandas Zakelis Mantas Deimantavicius Daiva Imbrasiene |
author_sort |
Basant K. Bajpai |
title |
Comparative Study of Novel Noninvasive Cerebral Autoregulation Volumetric Reactivity Indices Reflected by Ultrasonic Speed and Attenuation as Dynamic Measurements in the Human Brain |
title_short |
Comparative Study of Novel Noninvasive Cerebral Autoregulation Volumetric Reactivity Indices Reflected by Ultrasonic Speed and Attenuation as Dynamic Measurements in the Human Brain |
title_full |
Comparative Study of Novel Noninvasive Cerebral Autoregulation Volumetric Reactivity Indices Reflected by Ultrasonic Speed and Attenuation as Dynamic Measurements in the Human Brain |
title_fullStr |
Comparative Study of Novel Noninvasive Cerebral Autoregulation Volumetric Reactivity Indices Reflected by Ultrasonic Speed and Attenuation as Dynamic Measurements in the Human Brain |
title_full_unstemmed |
Comparative Study of Novel Noninvasive Cerebral Autoregulation Volumetric Reactivity Indices Reflected by Ultrasonic Speed and Attenuation as Dynamic Measurements in the Human Brain |
title_sort |
comparative study of novel noninvasive cerebral autoregulation volumetric reactivity indices reflected by ultrasonic speed and attenuation as dynamic measurements in the human brain |
publisher |
MDPI AG |
series |
Brain Sciences |
issn |
2076-3425 |
publishDate |
2020-04-01 |
description |
This is a comparative study of two novel noninvasive cerebrovascular autoregulation (CA) monitoring methods based on intracranial blood volume (IBV) changes in the human brain. We investigated the clinical applicability of the new volumetric reactivity index (VRx2), reflected by intracranial ultrasonic attenuation dynamics for noninvasive CA monitoring. The CA was determined noninvasively on 43 healthy participants by calculating the volumetric reactivity index (VRx1 from time-of-flight of ultrasound, VRx2 from attenuation of ultrasound). The VRx was calculated as a moving correlation coefficient between the arterial blood pressure and noninvasively measured IBV slow waves. Linear regression between VRx1 and VRx2 (averaged per participants) showed a significant correlation (<i>r</i> = 0.731, <i>p</i> < 0.0001, 95% confidence interval [0.501–0.895]) in data filtered by bandpass filtering. On the other hand, FIR filtering demonstrated a slightly better correlation (<i>r</i> = 0.769, <i>p</i> < 0.0001, 95% confidence interval [0.611–0.909]). The standard deviation of the difference by bandpass filtering was 0.1647 and bias −0.3444; and by FIR filtering 0.1382 and bias −0.3669. This comparative study showed a significant coincidence of the VRx2 index compared to that of VRx1. Hence, VRx2 could be used as an alternative, cost-effective noninvasive cerebrovascular autoregulation index in the same way as VRx1 values are used. |
topic |
ABP = arterial blood pressure CPP = cerebral perfusion pressure CA = cerebrovascular autoregulation ICP = intracranial pressure PRx = pressure reactivity index CBF = cerebral blood flow |
url |
https://www.mdpi.com/2076-3425/10/4/205 |
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