Lycopene in the management of oral lichen planus: A placebo-controlled study
Context: Oxidative stress has been implicated in the pathogenesis of lichen planus, and a lower level of lycopene has been reported in erosive and atrophic oral lichen planus (OLP) patients. However, its efficacy in the management of OLP has not been reported. Aim: This study was designed to assess...
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Wolters Kluwer Medknow Publications
2011-01-01
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doaj-012380beb2a743fab6df81dc0b48ea772020-11-25T02:47:45ZengWolters Kluwer Medknow PublicationsIndian Journal of Dental Research0970-92901998-36032011-01-0122563964310.4103/0970-9290.93448Lycopene in the management of oral lichen planus: A placebo-controlled studyNisheeth SaawarnM C ShashikanthSwati SaawarnVasanti JirgeNallan CSK ChaitanyaR PinakapaniContext: Oxidative stress has been implicated in the pathogenesis of lichen planus, and a lower level of lycopene has been reported in erosive and atrophic oral lichen planus (OLP) patients. However, its efficacy in the management of OLP has not been reported. Aim: This study was designed to assess the efficacy of systemic lycopene in the management of OLP. Settings and Design: This prospective, randomized, double-blind, placebo-controlled study was done in the Oral Medicine Department of a postgraduate teaching dental hospital in India. Materials and Methods: Thirty symptomatic OLP patients, randomly divided into two groups of 15 each, were administered lycopene 8 mg/day and an identical placebo, respectively, for 8 consecutive weeks. Burning sensation using visual analogue scale and overall treatment response using Tel Aviv-San Francisco scale were recorded at every visit. The data obtained were analyzed statistically using Wilcoxon Rank test, Mann-Whitney and Fischer′s Exact test. Results: A higher (84%) reduction in burning sensation was seen in lycopene than in the placebo group (67%). All 15 (100%) patients in the lycopene group showed 50% or more benefit and 11 (73.3%) patients showed 70-100% benefit, while this number was only 10 and 4 (26.7%), respectively, in the placebo group. Conclusion: Lycopene was very effective in the management of OLP, and oxidative stress may have a role in disease pathogenesis.http://www.ijdr.in/article.asp?issn=0970-9290;year=2011;volume=22;issue=5;spage=639;epage=643;aulast=SaawarnAntioxidantfree radicalslycopeneoral lichen planusoxidative stress |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nisheeth Saawarn M C Shashikanth Swati Saawarn Vasanti Jirge Nallan CSK Chaitanya R Pinakapani |
spellingShingle |
Nisheeth Saawarn M C Shashikanth Swati Saawarn Vasanti Jirge Nallan CSK Chaitanya R Pinakapani Lycopene in the management of oral lichen planus: A placebo-controlled study Indian Journal of Dental Research Antioxidant free radicals lycopene oral lichen planus oxidative stress |
author_facet |
Nisheeth Saawarn M C Shashikanth Swati Saawarn Vasanti Jirge Nallan CSK Chaitanya R Pinakapani |
author_sort |
Nisheeth Saawarn |
title |
Lycopene in the management of oral lichen planus: A placebo-controlled study |
title_short |
Lycopene in the management of oral lichen planus: A placebo-controlled study |
title_full |
Lycopene in the management of oral lichen planus: A placebo-controlled study |
title_fullStr |
Lycopene in the management of oral lichen planus: A placebo-controlled study |
title_full_unstemmed |
Lycopene in the management of oral lichen planus: A placebo-controlled study |
title_sort |
lycopene in the management of oral lichen planus: a placebo-controlled study |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Dental Research |
issn |
0970-9290 1998-3603 |
publishDate |
2011-01-01 |
description |
Context: Oxidative stress has been implicated in the pathogenesis of lichen planus, and a lower level of lycopene has been reported in erosive and atrophic oral lichen planus (OLP) patients. However, its efficacy in the management of OLP has not been reported.
Aim: This study was designed to assess the efficacy of systemic lycopene in the management of OLP.
Settings and Design: This prospective, randomized, double-blind, placebo-controlled study was done in the Oral Medicine Department of a postgraduate teaching dental hospital in India.
Materials and Methods: Thirty symptomatic OLP patients, randomly divided into two groups of 15 each, were administered lycopene 8 mg/day and an identical placebo, respectively, for 8 consecutive weeks. Burning sensation using visual analogue scale and overall treatment response using Tel Aviv-San Francisco scale were recorded at every visit. The data obtained were analyzed statistically using Wilcoxon Rank test, Mann-Whitney and Fischer′s Exact test.
Results: A higher (84%) reduction in burning sensation was seen in lycopene than in the placebo group (67%). All 15 (100%) patients in the lycopene group showed 50% or more benefit and 11 (73.3%) patients showed 70-100% benefit, while this number was only 10 and 4 (26.7%), respectively, in the placebo group.
Conclusion: Lycopene was very effective in the management of OLP, and oxidative stress may have a role in disease pathogenesis. |
topic |
Antioxidant free radicals lycopene oral lichen planus oxidative stress |
url |
http://www.ijdr.in/article.asp?issn=0970-9290;year=2011;volume=22;issue=5;spage=639;epage=643;aulast=Saawarn |
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