Re-imagining the future of diagnosis of Neglected Tropical Diseases
Neglected Tropical Diseases (NTDs) affect an estimated 1 billion people in 149 countries. The World Health Organization (WHO) prioritised 17 NTDs for control and elimination by 2020 and defined a Road Map to help countries reach these goals. Improved diagnostics for NTDs are essential for guiding tr...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2017-01-01
|
Series: | Computational and Structural Biotechnology Journal |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037016301015 |
id |
doaj-01252ccf8bd24a4cb0d6d7de901c740f |
---|---|
record_format |
Article |
spelling |
doaj-01252ccf8bd24a4cb0d6d7de901c740f2020-11-25T02:25:56ZengElsevierComputational and Structural Biotechnology Journal2001-03702017-01-0115271274Re-imagining the future of diagnosis of Neglected Tropical DiseasesRosanna W. Peeling0Debrah I. Boeras1John Nkengasong2LONDON School of Hygiene and Tropical Medicine, United Kingdom; Corresponding author at: London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom.LONDON School of Hygiene and Tropical Medicine, United KingdomCenters for Disease Control and Prevention, USANeglected Tropical Diseases (NTDs) affect an estimated 1 billion people in 149 countries. The World Health Organization (WHO) prioritised 17 NTDs for control and elimination by 2020 and defined a Road Map to help countries reach these goals. Improved diagnostics for NTDs are essential for guiding treatment strategies at different thresholds of control, interruption of transmission, elimination and post-elimination surveillance. While substantial progress has been made in the last decade with chemotherapy, the same cannot be said of diagnostics, largely due to the perceived lack of a commercially viable market for NTD diagnostics.New sample in-answer out nucleic acid amplification technologies that can be performed at the point-of-care offer improved performance over current technologies and the potential to test for multiple pathogens using a single specimen. Finding commonalities for different NTDs in terms of geographic overlap, sentinel populations and treatment strategy will allow NTD programs to leverage these innovations to build cost-effective multiplex surveillance platforms. Connectivity solutions linking data from diagnostic laboratories and POC test readers/devices provide opportunities for automated surveillance systems to make health systems more efficient, improving patient outcomes and assessing impact of interventions in real time. New models of public–private product development partnerships are critical in leveraging diagnostic innovation in other priority area for better diagnosis, control and elimination of NTDs. Keywords: Neglected tropical diseases, Diagnostics, Control, Elimination, Surveillancehttp://www.sciencedirect.com/science/article/pii/S2001037016301015 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rosanna W. Peeling Debrah I. Boeras John Nkengasong |
spellingShingle |
Rosanna W. Peeling Debrah I. Boeras John Nkengasong Re-imagining the future of diagnosis of Neglected Tropical Diseases Computational and Structural Biotechnology Journal |
author_facet |
Rosanna W. Peeling Debrah I. Boeras John Nkengasong |
author_sort |
Rosanna W. Peeling |
title |
Re-imagining the future of diagnosis of Neglected Tropical Diseases |
title_short |
Re-imagining the future of diagnosis of Neglected Tropical Diseases |
title_full |
Re-imagining the future of diagnosis of Neglected Tropical Diseases |
title_fullStr |
Re-imagining the future of diagnosis of Neglected Tropical Diseases |
title_full_unstemmed |
Re-imagining the future of diagnosis of Neglected Tropical Diseases |
title_sort |
re-imagining the future of diagnosis of neglected tropical diseases |
publisher |
Elsevier |
series |
Computational and Structural Biotechnology Journal |
issn |
2001-0370 |
publishDate |
2017-01-01 |
description |
Neglected Tropical Diseases (NTDs) affect an estimated 1 billion people in 149 countries. The World Health Organization (WHO) prioritised 17 NTDs for control and elimination by 2020 and defined a Road Map to help countries reach these goals. Improved diagnostics for NTDs are essential for guiding treatment strategies at different thresholds of control, interruption of transmission, elimination and post-elimination surveillance. While substantial progress has been made in the last decade with chemotherapy, the same cannot be said of diagnostics, largely due to the perceived lack of a commercially viable market for NTD diagnostics.New sample in-answer out nucleic acid amplification technologies that can be performed at the point-of-care offer improved performance over current technologies and the potential to test for multiple pathogens using a single specimen. Finding commonalities for different NTDs in terms of geographic overlap, sentinel populations and treatment strategy will allow NTD programs to leverage these innovations to build cost-effective multiplex surveillance platforms. Connectivity solutions linking data from diagnostic laboratories and POC test readers/devices provide opportunities for automated surveillance systems to make health systems more efficient, improving patient outcomes and assessing impact of interventions in real time. New models of public–private product development partnerships are critical in leveraging diagnostic innovation in other priority area for better diagnosis, control and elimination of NTDs. Keywords: Neglected tropical diseases, Diagnostics, Control, Elimination, Surveillance |
url |
http://www.sciencedirect.com/science/article/pii/S2001037016301015 |
work_keys_str_mv |
AT rosannawpeeling reimaginingthefutureofdiagnosisofneglectedtropicaldiseases AT debrahiboeras reimaginingthefutureofdiagnosisofneglectedtropicaldiseases AT johnnkengasong reimaginingthefutureofdiagnosisofneglectedtropicaldiseases |
_version_ |
1724849371526201344 |