Degree of Tissue Differentiation Dictates Susceptibility to BRAF-Driven Colorectal Cancer

Degree of Tissue Differentiation Dictates Susceptibility to BRAF-Driven Colorectal Cancer

Oncogenic mutations in BRAF are believed to initiate serrated colorectal cancers; however, the mechanisms of BRAF-driven colon cancer are unclear. We find that oncogenic BRAF paradoxically suppresses stem cell renewal and instead promotes differentiation. Correspondingly, tumor formation is ineffici...

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Bibliographic Details
Main Authors: Kevin Tong, Oscar Pellón-Cárdenas, Veerin R. Sirihorachai, Bailey N. Warder, Om A. Kothari, Ansu O. Perekatt, Emily E. Fokas, Robert L. Fullem, Anbo Zhou, Joshua K. Thackray, Hiep Tran, Lanjing Zhang, Jinchuan Xing, Michael P. Verzi
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Cell Reports
Subjects:
Cdx2
BRAF
Smad4
intestinal homeostasis
serrated colorectal cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717317886

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