Reduction of Matrix Metallopeptidase 13 and Promotion of Chondrogenesis by Zeel T in Primary Human Osteoarthritic Chondrocytes

Reduction of Matrix Metallopeptidase 13 and Promotion of Chondrogenesis by Zeel T in Primary Human Osteoarthritic Chondrocytes

Objectives: Zeel T (Ze14) is a multicomponent medicinal product. Initial preclinical data suggested a preventive effect on cartilage degradation. Clinical observational studies demonstrated that Ze14 reduced symptoms of osteoarthritis (OA), including stiffness and pain. This study aimed to explore t...

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Bibliographic Details
Main Authors: Christelle Sanchez, Kathrin Hemmer, Natascha Krömmelbein, Bernd Seilheimer, Jean-Emile Dubuc, Christophe Antoine, Yves Henrotin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
osteoarthritis
cartilage
chondrogenesis
zeel T
MMP13
multitarget
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.635034/full

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