Sea Cucumber-Derived Peptides Alleviate Oxidative Stress in Neuroblastoma Cells and Improve Survival in C. elegans Exposed to Neurotoxic Paraquat
Oxidative stress results when the production of oxidants outweighs the capacity of the antioxidant defence mechanisms. This can lead to pathological conditions including cancer and neurodegeneration. Consequently, there is considerable interest in compounds with antioxidant activity, including those...
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Hindawi Limited
2021-01-01
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Series: | Oxidative Medicine and Cellular Longevity |
Online Access: | http://dx.doi.org/10.1155/2021/8842926 |
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doaj-0134127822254a6b87fcec9c835e73512021-05-03T00:01:40ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09942021-01-01202110.1155/2021/8842926Sea Cucumber-Derived Peptides Alleviate Oxidative Stress in Neuroblastoma Cells and Improve Survival in C. elegans Exposed to Neurotoxic ParaquatMeng Lu0Ajay Mishra1Chiara Boschetti2Jing Lin3Yushuang Liu4Hongliang Huang5Clemens F. Kaminski6Zebo Huang7Alan Tunnacliffe8Gabriele S. Kaminski Schierle9Cambridge Infinitus Research CentreCambridge Infinitus Research CentreCambridge Infinitus Research CentreResearch Institute for Food Nutrition and Human HealthSchool of Biosciences and BiopharmaceuticsSchool of Biosciences and BiopharmaceuticsCambridge Infinitus Research CentreResearch Institute for Food Nutrition and Human HealthCambridge Infinitus Research CentreCambridge Infinitus Research CentreOxidative stress results when the production of oxidants outweighs the capacity of the antioxidant defence mechanisms. This can lead to pathological conditions including cancer and neurodegeneration. Consequently, there is considerable interest in compounds with antioxidant activity, including those from natural sources. Here, we characterise the antioxidant activity of three novel peptides identified in protein hydrolysates from the sea cucumber Apostichopus japonicus. Under oxidative stress conditions, synthetic versions of the sea cucumber peptides significantly compensate for glutathione depletion, decrease mitochondrial superoxide levels, and alleviate mitophagy in human neuroblastoma cells. Moreover, orally supplied peptides improve survival of the Caenorhabditis elegans after treatment with paraquat, the latter of which leads to the production of excessive oxidative stress. Thus, the sea cucumber peptides exhibit antioxidant activity at both the cellular and organism levels and might prove attractive as nutritional supplements for healthy ageing.http://dx.doi.org/10.1155/2021/8842926 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Meng Lu Ajay Mishra Chiara Boschetti Jing Lin Yushuang Liu Hongliang Huang Clemens F. Kaminski Zebo Huang Alan Tunnacliffe Gabriele S. Kaminski Schierle |
spellingShingle |
Meng Lu Ajay Mishra Chiara Boschetti Jing Lin Yushuang Liu Hongliang Huang Clemens F. Kaminski Zebo Huang Alan Tunnacliffe Gabriele S. Kaminski Schierle Sea Cucumber-Derived Peptides Alleviate Oxidative Stress in Neuroblastoma Cells and Improve Survival in C. elegans Exposed to Neurotoxic Paraquat Oxidative Medicine and Cellular Longevity |
author_facet |
Meng Lu Ajay Mishra Chiara Boschetti Jing Lin Yushuang Liu Hongliang Huang Clemens F. Kaminski Zebo Huang Alan Tunnacliffe Gabriele S. Kaminski Schierle |
author_sort |
Meng Lu |
title |
Sea Cucumber-Derived Peptides Alleviate Oxidative Stress in Neuroblastoma Cells and Improve Survival in C. elegans Exposed to Neurotoxic Paraquat |
title_short |
Sea Cucumber-Derived Peptides Alleviate Oxidative Stress in Neuroblastoma Cells and Improve Survival in C. elegans Exposed to Neurotoxic Paraquat |
title_full |
Sea Cucumber-Derived Peptides Alleviate Oxidative Stress in Neuroblastoma Cells and Improve Survival in C. elegans Exposed to Neurotoxic Paraquat |
title_fullStr |
Sea Cucumber-Derived Peptides Alleviate Oxidative Stress in Neuroblastoma Cells and Improve Survival in C. elegans Exposed to Neurotoxic Paraquat |
title_full_unstemmed |
Sea Cucumber-Derived Peptides Alleviate Oxidative Stress in Neuroblastoma Cells and Improve Survival in C. elegans Exposed to Neurotoxic Paraquat |
title_sort |
sea cucumber-derived peptides alleviate oxidative stress in neuroblastoma cells and improve survival in c. elegans exposed to neurotoxic paraquat |
publisher |
Hindawi Limited |
series |
Oxidative Medicine and Cellular Longevity |
issn |
1942-0994 |
publishDate |
2021-01-01 |
description |
Oxidative stress results when the production of oxidants outweighs the capacity of the antioxidant defence mechanisms. This can lead to pathological conditions including cancer and neurodegeneration. Consequently, there is considerable interest in compounds with antioxidant activity, including those from natural sources. Here, we characterise the antioxidant activity of three novel peptides identified in protein hydrolysates from the sea cucumber Apostichopus japonicus. Under oxidative stress conditions, synthetic versions of the sea cucumber peptides significantly compensate for glutathione depletion, decrease mitochondrial superoxide levels, and alleviate mitophagy in human neuroblastoma cells. Moreover, orally supplied peptides improve survival of the Caenorhabditis elegans after treatment with paraquat, the latter of which leads to the production of excessive oxidative stress. Thus, the sea cucumber peptides exhibit antioxidant activity at both the cellular and organism levels and might prove attractive as nutritional supplements for healthy ageing. |
url |
http://dx.doi.org/10.1155/2021/8842926 |
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