Control of Adipocyte Thermogenesis and Lipogenesis through β3-Adrenergic and Thyroid Hormone Signal Integration

Control of Adipocyte Thermogenesis and Lipogenesis through β3-Adrenergic and Thyroid Hormone Signal Integration

Summary: Here, we show that β adrenergic signaling coordinately upregulates de novo lipogenesis (DNL) and thermogenesis in subcutaneous white adipose tissue (sWAT), and both effects are blocked in mice lacking the cAMP-generating G protein-coupled receptor Gs (Adipo-GsαKO) in adipocytes. However, UC...

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Bibliographic Details
Main Authors: Adilson Guilherme, Batuhan Yenilmez, Alexander H. Bedard, Felipe Henriques, Dianxin Liu, Alexandra Lee, Lauren Goldstein, Mark Kelly, Sarah M. Nicoloro, Min Chen, Lee Weinstein, Sheila Collins, Michael P. Czech
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Cell Reports
Subjects:
beige adipocytes
de novo lipogenesis
sympathetic nerve
thyroid hormones
Adrb3
mTORC1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720305477

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http://www.sciencedirect.com/science/article/pii/S2211124720305477

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