Predictor Analysis in Radiofrequency Ablation of Benign Thyroid Nodules: A Single Center Experience
PurposeTo confirm the efficacy of ultrasound (US) guided radiofrequency ablation (RFA) in the treatment of benign thyroid nodules, we evaluated as primary outcome the technical efficacy and clinical success in a single center dataset. The secondary outcome was to find a correlation between nodules’...
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Frontiers Media S.A.
2021-05-01
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Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2021.638880/full |
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doaj-01395e06b9d8407cb28fee8237c4e16b |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alessandro Bisceglia Ruth Rossetto Sara Garberoglio Sara Garberoglio Angelica Franzin Alice Cerato Francesca Maletta Mauro Giulio Papotti Ezio Ghigo Loredana Pagano Mauro Maccario Roberto Garberoglio Roberto Garberoglio |
spellingShingle |
Alessandro Bisceglia Ruth Rossetto Sara Garberoglio Sara Garberoglio Angelica Franzin Alice Cerato Francesca Maletta Mauro Giulio Papotti Ezio Ghigo Loredana Pagano Mauro Maccario Roberto Garberoglio Roberto Garberoglio Predictor Analysis in Radiofrequency Ablation of Benign Thyroid Nodules: A Single Center Experience Frontiers in Endocrinology predictive factors efficacy of radiofrequency ablation radiofrequency ablation (RFA) benign thyroid nodules volume reduction |
author_facet |
Alessandro Bisceglia Ruth Rossetto Sara Garberoglio Sara Garberoglio Angelica Franzin Alice Cerato Francesca Maletta Mauro Giulio Papotti Ezio Ghigo Loredana Pagano Mauro Maccario Roberto Garberoglio Roberto Garberoglio |
author_sort |
Alessandro Bisceglia |
title |
Predictor Analysis in Radiofrequency Ablation of Benign Thyroid Nodules: A Single Center Experience |
title_short |
Predictor Analysis in Radiofrequency Ablation of Benign Thyroid Nodules: A Single Center Experience |
title_full |
Predictor Analysis in Radiofrequency Ablation of Benign Thyroid Nodules: A Single Center Experience |
title_fullStr |
Predictor Analysis in Radiofrequency Ablation of Benign Thyroid Nodules: A Single Center Experience |
title_full_unstemmed |
Predictor Analysis in Radiofrequency Ablation of Benign Thyroid Nodules: A Single Center Experience |
title_sort |
predictor analysis in radiofrequency ablation of benign thyroid nodules: a single center experience |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Endocrinology |
issn |
1664-2392 |
publishDate |
2021-05-01 |
description |
PurposeTo confirm the efficacy of ultrasound (US) guided radiofrequency ablation (RFA) in the treatment of benign thyroid nodules, we evaluated as primary outcome the technical efficacy and clinical success in a single center dataset. The secondary outcome was to find a correlation between nodules’ pre-treatment features and volume reduction rate (VRR) ≥75% at 12 months after RFA and during follow-up period.MethodsThis retrospective study included 119 consecutive patients (99 females, 20 males, 51.5 ± 14.4 years) with benign thyroid nodules treated in our hospital between October 2014 and December 2018 with a mean follow-up of 26.8 months (range 3–48). Clinical and US features before and after RFA were evaluated by a US examination at 1, 3, 6, 12 months and annually thereafter up to 48 months.ResultsThe median pre-treatment volume was 22.4 ml; after RFA we observed a statistically significant volume reduction from the first month (11.7 ml) to the last follow-up (p < 0.001 for all follow-up times). The median VRR was 47.1, 55.3, 61.2, 67.6, 72.8, 71.3, and 62.9% at 1, 3, 6, 12, 24, 36, and 48 months of follow-up respectively, showing a progressive significant improvement up to 24 months (VRRs 1 vs 3 months, 3 vs 6 months and 6 vs 12 months p < 0.001, 12 vs 24 months p = 0.05) while no differences at 24 vs 36 and 36 vs 48 months were observed. Symptoms improved significantly (complete resolution 64.35%, partial resolution 35.65%), and neck circumference was reduced as compared to pre-treatment (p < 0.001). Lower pre-treatment neck circumference (37.5 vs 36.0 cm, p = 0.01) was a positive predictor of VRR ≥75% at 12 months. Macrocystic echostructure (HR 2.48, p 0.046) and pre-treatment volume >22.4 ml (HR 0.54, p 0.036) were found to be independent positive and negative predictors of VRR ≥75% respectively. One-month post RFA VRR ≥50% represented the best positive predictor of technical success.ConclusionsThis study confirmed the efficacy of RFA in the treatment of benign thyroid nodules. In particular we show that by selecting macrocystic nodules smaller than 22.4 ml better long-term response can be achieved, which is predicted by an early shrinkage of the nodule. |
topic |
predictive factors efficacy of radiofrequency ablation radiofrequency ablation (RFA) benign thyroid nodules volume reduction |
url |
https://www.frontiersin.org/articles/10.3389/fendo.2021.638880/full |
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doaj-01395e06b9d8407cb28fee8237c4e16b2021-05-17T06:20:57ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-05-011210.3389/fendo.2021.638880638880Predictor Analysis in Radiofrequency Ablation of Benign Thyroid Nodules: A Single Center ExperienceAlessandro Bisceglia0Ruth Rossetto1Sara Garberoglio2Sara Garberoglio3Angelica Franzin4Alice Cerato5Francesca Maletta6Mauro Giulio Papotti7Ezio Ghigo8Loredana Pagano9Mauro Maccario10Roberto Garberoglio11Roberto Garberoglio12Division of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, ItalyDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, ItalyDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, ItalyCentro Multidisciplinare Della Tiroide (CMT), Humanitas Cellini, Turin, ItalyDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, ItalyDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, ItalyPathology Unit, Department of Laboratory Medicine, City of Health and Science Hospital, Turin, ItalyPathology Unit, Department of Oncology, University of Turin and City of Health and Science Hospital, Turin, ItalyDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, ItalyDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, ItalyDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, ItalyDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, ItalyCentro Multidisciplinare Della Tiroide (CMT), Humanitas Cellini, Turin, ItalyPurposeTo confirm the efficacy of ultrasound (US) guided radiofrequency ablation (RFA) in the treatment of benign thyroid nodules, we evaluated as primary outcome the technical efficacy and clinical success in a single center dataset. The secondary outcome was to find a correlation between nodules’ pre-treatment features and volume reduction rate (VRR) ≥75% at 12 months after RFA and during follow-up period.MethodsThis retrospective study included 119 consecutive patients (99 females, 20 males, 51.5 ± 14.4 years) with benign thyroid nodules treated in our hospital between October 2014 and December 2018 with a mean follow-up of 26.8 months (range 3–48). Clinical and US features before and after RFA were evaluated by a US examination at 1, 3, 6, 12 months and annually thereafter up to 48 months.ResultsThe median pre-treatment volume was 22.4 ml; after RFA we observed a statistically significant volume reduction from the first month (11.7 ml) to the last follow-up (p < 0.001 for all follow-up times). The median VRR was 47.1, 55.3, 61.2, 67.6, 72.8, 71.3, and 62.9% at 1, 3, 6, 12, 24, 36, and 48 months of follow-up respectively, showing a progressive significant improvement up to 24 months (VRRs 1 vs 3 months, 3 vs 6 months and 6 vs 12 months p < 0.001, 12 vs 24 months p = 0.05) while no differences at 24 vs 36 and 36 vs 48 months were observed. Symptoms improved significantly (complete resolution 64.35%, partial resolution 35.65%), and neck circumference was reduced as compared to pre-treatment (p < 0.001). Lower pre-treatment neck circumference (37.5 vs 36.0 cm, p = 0.01) was a positive predictor of VRR ≥75% at 12 months. Macrocystic echostructure (HR 2.48, p 0.046) and pre-treatment volume >22.4 ml (HR 0.54, p 0.036) were found to be independent positive and negative predictors of VRR ≥75% respectively. One-month post RFA VRR ≥50% represented the best positive predictor of technical success.ConclusionsThis study confirmed the efficacy of RFA in the treatment of benign thyroid nodules. In particular we show that by selecting macrocystic nodules smaller than 22.4 ml better long-term response can be achieved, which is predicted by an early shrinkage of the nodule.https://www.frontiersin.org/articles/10.3389/fendo.2021.638880/fullpredictive factorsefficacy of radiofrequency ablationradiofrequency ablation (RFA)benign thyroid nodulesvolume reduction |