15-deoxy-Δ12,14-prostaglandin J2 inhibits the expression of microsomal prostaglandin E synthase type 2 in colon cancer cells

15-deoxy-Δ12,14-prostaglandin J2 inhibits the expression of microsomal prostaglandin E synthase type 2 in colon cancer cells

Prostaglandin (PG) E2 (PGE2) plays a predominant role in promoting colorectal carcinogenesis. The biosynthesis of PGE2 is accomplished by conversion of the cyclooxygenase (COX) product PGH2 by several terminal prostaglandin E synthases (PGES). Among the known PGES isoforms, microsomal PGES type 1 (m...

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Bibliographic Details
Main Authors: Oliver Schroäder, Yulyana Yudina, Alan Sabirsh, Nadine Zahn, Jesper Z. Haeggstroäm, Juärgen Stein
Format: Article
Language:English
Published: Elsevier 2006-05-01
Series:Journal of Lipid Research
Subjects:
colorectal cancer
cyclopentenone prostaglandins
feedback control
proliferation
prostaglandin E2
redox status
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520332569

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http://www.sciencedirect.com/science/article/pii/S0022227520332569

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