Dichloroacetate (DCA) and Cancer: An Overview towards Clinical Applications
An extensive body of literature describes anticancer property of dichloroacetate (DCA), but its effective clinical administration in cancer therapy is still limited to clinical trials. The occurrence of side effects such as neurotoxicity as well as the suspicion of DCA carcinogenicity still restrict...
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Series: | Oxidative Medicine and Cellular Longevity |
Online Access: | http://dx.doi.org/10.1155/2019/8201079 |
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doaj-01702d3275c947349b9131a2c5c563292020-11-25T01:34:37ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942019-01-01201910.1155/2019/82010798201079Dichloroacetate (DCA) and Cancer: An Overview towards Clinical ApplicationsTiziana Tataranni0Claudia Piccoli1Laboratory of Pre-Clinical and Translational Research, IRCCS-CROB, Referral Cancer Center of Basilicata, Rionero in Vulture (Pz), 85028, ItalyLaboratory of Pre-Clinical and Translational Research, IRCCS-CROB, Referral Cancer Center of Basilicata, Rionero in Vulture (Pz), 85028, ItalyAn extensive body of literature describes anticancer property of dichloroacetate (DCA), but its effective clinical administration in cancer therapy is still limited to clinical trials. The occurrence of side effects such as neurotoxicity as well as the suspicion of DCA carcinogenicity still restricts the clinical use of DCA. However, in the last years, the number of reports supporting DCA employment against cancer increased also because of the great interest in targeting metabolism of tumour cells. Dissecting DCA mechanism of action helped to understand the bases of its selective efficacy against cancer cells. A successful coadministration of DCA with conventional chemotherapy, radiotherapy, other drugs, or natural compounds has been tested in several cancer models. New drug delivery systems and multiaction compounds containing DCA and other drugs seem to ameliorate bioavailability and appear more efficient thanks to a synergistic action of multiple agents. The spread of reports supporting the efficiency of DCA in cancer therapy has prompted additional studies that let to find other potential molecular targets of DCA. Interestingly, DCA could significantly affect cancer stem cell fraction and contribute to cancer eradication. Collectively, these findings provide a strong rationale towards novel clinical translational studies of DCA in cancer therapy.http://dx.doi.org/10.1155/2019/8201079 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tiziana Tataranni Claudia Piccoli |
spellingShingle |
Tiziana Tataranni Claudia Piccoli Dichloroacetate (DCA) and Cancer: An Overview towards Clinical Applications Oxidative Medicine and Cellular Longevity |
author_facet |
Tiziana Tataranni Claudia Piccoli |
author_sort |
Tiziana Tataranni |
title |
Dichloroacetate (DCA) and Cancer: An Overview towards Clinical Applications |
title_short |
Dichloroacetate (DCA) and Cancer: An Overview towards Clinical Applications |
title_full |
Dichloroacetate (DCA) and Cancer: An Overview towards Clinical Applications |
title_fullStr |
Dichloroacetate (DCA) and Cancer: An Overview towards Clinical Applications |
title_full_unstemmed |
Dichloroacetate (DCA) and Cancer: An Overview towards Clinical Applications |
title_sort |
dichloroacetate (dca) and cancer: an overview towards clinical applications |
publisher |
Hindawi Limited |
series |
Oxidative Medicine and Cellular Longevity |
issn |
1942-0900 1942-0994 |
publishDate |
2019-01-01 |
description |
An extensive body of literature describes anticancer property of dichloroacetate (DCA), but its effective clinical administration in cancer therapy is still limited to clinical trials. The occurrence of side effects such as neurotoxicity as well as the suspicion of DCA carcinogenicity still restricts the clinical use of DCA. However, in the last years, the number of reports supporting DCA employment against cancer increased also because of the great interest in targeting metabolism of tumour cells. Dissecting DCA mechanism of action helped to understand the bases of its selective efficacy against cancer cells. A successful coadministration of DCA with conventional chemotherapy, radiotherapy, other drugs, or natural compounds has been tested in several cancer models. New drug delivery systems and multiaction compounds containing DCA and other drugs seem to ameliorate bioavailability and appear more efficient thanks to a synergistic action of multiple agents. The spread of reports supporting the efficiency of DCA in cancer therapy has prompted additional studies that let to find other potential molecular targets of DCA. Interestingly, DCA could significantly affect cancer stem cell fraction and contribute to cancer eradication. Collectively, these findings provide a strong rationale towards novel clinical translational studies of DCA in cancer therapy. |
url |
http://dx.doi.org/10.1155/2019/8201079 |
work_keys_str_mv |
AT tizianatataranni dichloroacetatedcaandcanceranoverviewtowardsclinicalapplications AT claudiapiccoli dichloroacetatedcaandcanceranoverviewtowardsclinicalapplications |
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