Comparative genomics of 10 new Caenorhabditis species
Abstract The nematode Caenorhabditis elegans has been central to the understanding of metazoan biology. However, C. elegans is but one species among millions and the significance of this important model organism will only be fully revealed if it is placed in a rich evolutionary context. Global sampl...
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doaj-0172c8df07ff4c68bc9e4b7dd9d6090c2020-11-24T22:04:02ZengWileyEvolution Letters2056-37442019-04-013221723610.1002/evl3.110Comparative genomics of 10 new Caenorhabditis speciesLewis Stevens0Marie‐Anne Félix1Toni Beltran2Christian Braendle3Carlos Caurcel4Sarah Fausett5David Fitch6Lise Frézal7Charlie Gosse8Taniya Kaur9Karin Kiontke10Matthew D. Newton11Luke M. Noble12Aurélien Richaud13Matthew V. Rockman14Walter Sudhaus15Mark Blaxter16Institute of Evolutionary Biology, Ashworth Laboratories, School of Biological Sciences University of Edinburgh Edinburgh EH9 3JT United KingdomInstitut de Biologie de l'Ecole Normale Supérieure, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, École Normale Supérieure Paris Sciences et Lettres 75005 Paris FranceMRC London Institute of Medical Sciences London W12 0NN United KingdomUniversité Côte d'Azur, Centre National de la Recherche Scientifique, Inserm Institute of Biology Valrose 06108 Nice FranceInstitute of Evolutionary Biology, Ashworth Laboratories, School of Biological Sciences University of Edinburgh Edinburgh EH9 3JT United KingdomUniversité Côte d'Azur, Centre National de la Recherche Scientifique, Inserm Institute of Biology Valrose 06108 Nice FranceDepartment of Biology New York University New York New York 10003Institut de Biologie de l'Ecole Normale Supérieure, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, École Normale Supérieure Paris Sciences et Lettres 75005 Paris FranceInstitut de Biologie de l'Ecole Normale Supérieure, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, École Normale Supérieure Paris Sciences et Lettres 75005 Paris FranceCenter for Genomics and Systems Biology, Department of Biology New York University New York New York 10003Department of Biology New York University New York New York 10003MRC London Institute of Medical Sciences London W12 0NN United KingdomCenter for Genomics and Systems Biology, Department of Biology New York University New York New York 10003Institut de Biologie de l'Ecole Normale Supérieure, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, École Normale Supérieure Paris Sciences et Lettres 75005 Paris FranceCenter for Genomics and Systems Biology, Department of Biology New York University New York New York 10003Institut für Biologie/Zoologie Freie Universität Berlin Berlin D‐14195 GermanyInstitute of Evolutionary Biology, Ashworth Laboratories, School of Biological Sciences University of Edinburgh Edinburgh EH9 3JT United KingdomAbstract The nematode Caenorhabditis elegans has been central to the understanding of metazoan biology. However, C. elegans is but one species among millions and the significance of this important model organism will only be fully revealed if it is placed in a rich evolutionary context. Global sampling efforts have led to the discovery of over 50 putative species from the genus Caenorhabditis, many of which await formal species description. Here, we present species descriptions for 10 new Caenorhabditis species. We also present draft genome sequences for nine of these new species, along with a transcriptome assembly for one. We exploit these whole‐genome data to reconstruct the Caenorhabditis phylogeny and use this phylogenetic tree to dissect the evolution of morphology in the genus. We reveal extensive variation in genome size and investigate the molecular processes that underlie this variation. We show unexpected complexity in the evolutionary history of key developmental pathway genes. These new species and the associated genomic resources will be essential in our attempts to understand the evolutionary origins of the C. elegans model.https://doi.org/10.1002/evl3.110C. elegansgenomicsphylogenomicsmorphologyspecies description |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lewis Stevens Marie‐Anne Félix Toni Beltran Christian Braendle Carlos Caurcel Sarah Fausett David Fitch Lise Frézal Charlie Gosse Taniya Kaur Karin Kiontke Matthew D. Newton Luke M. Noble Aurélien Richaud Matthew V. Rockman Walter Sudhaus Mark Blaxter |
spellingShingle |
Lewis Stevens Marie‐Anne Félix Toni Beltran Christian Braendle Carlos Caurcel Sarah Fausett David Fitch Lise Frézal Charlie Gosse Taniya Kaur Karin Kiontke Matthew D. Newton Luke M. Noble Aurélien Richaud Matthew V. Rockman Walter Sudhaus Mark Blaxter Comparative genomics of 10 new Caenorhabditis species Evolution Letters C. elegans genomics phylogenomics morphology species description |
author_facet |
Lewis Stevens Marie‐Anne Félix Toni Beltran Christian Braendle Carlos Caurcel Sarah Fausett David Fitch Lise Frézal Charlie Gosse Taniya Kaur Karin Kiontke Matthew D. Newton Luke M. Noble Aurélien Richaud Matthew V. Rockman Walter Sudhaus Mark Blaxter |
author_sort |
Lewis Stevens |
title |
Comparative genomics of 10 new Caenorhabditis species |
title_short |
Comparative genomics of 10 new Caenorhabditis species |
title_full |
Comparative genomics of 10 new Caenorhabditis species |
title_fullStr |
Comparative genomics of 10 new Caenorhabditis species |
title_full_unstemmed |
Comparative genomics of 10 new Caenorhabditis species |
title_sort |
comparative genomics of 10 new caenorhabditis species |
publisher |
Wiley |
series |
Evolution Letters |
issn |
2056-3744 |
publishDate |
2019-04-01 |
description |
Abstract The nematode Caenorhabditis elegans has been central to the understanding of metazoan biology. However, C. elegans is but one species among millions and the significance of this important model organism will only be fully revealed if it is placed in a rich evolutionary context. Global sampling efforts have led to the discovery of over 50 putative species from the genus Caenorhabditis, many of which await formal species description. Here, we present species descriptions for 10 new Caenorhabditis species. We also present draft genome sequences for nine of these new species, along with a transcriptome assembly for one. We exploit these whole‐genome data to reconstruct the Caenorhabditis phylogeny and use this phylogenetic tree to dissect the evolution of morphology in the genus. We reveal extensive variation in genome size and investigate the molecular processes that underlie this variation. We show unexpected complexity in the evolutionary history of key developmental pathway genes. These new species and the associated genomic resources will be essential in our attempts to understand the evolutionary origins of the C. elegans model. |
topic |
C. elegans genomics phylogenomics morphology species description |
url |
https://doi.org/10.1002/evl3.110 |
work_keys_str_mv |
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