Dendrimer Prodrugs

The main objective of this review is to describe the importance of dendrimer prodrugs in the design of new drugs, presenting numerous applications of these nanocomposites in the pharmaceutical field. Therefore, the use of dendrimer prodrugs as carrier for drug delivery, to improve pharmacokinetic pr...

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Bibliographic Details
Main Authors: Soraya da Silva Santos, Elizabeth Igne Ferreira, Jeanine Giarolla
Format: Article
Language:English
Published: MDPI AG 2016-05-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/21/6/686
Description
Summary:The main objective of this review is to describe the importance of dendrimer prodrugs in the design of new drugs, presenting numerous applications of these nanocomposites in the pharmaceutical field. Therefore, the use of dendrimer prodrugs as carrier for drug delivery, to improve pharmacokinetic properties of prototype, to promote drug sustained-release, to increase selectivity and, consequently, to decrease toxicity, are just some examples of topics that have been extensively reported in the literature, especially in the last decade. The examples discussed here give a panel of the growing interest dendrimer prodrugs have been evoking in the scientific community.
ISSN:1420-3049