Synaptic Homeostasis and Allostasis in the Dentate Gyrus Caused by Inflammatory and Neuropathic Pain Conditions
It has been generally accepted that pain can cause imbalance between excitation and inhibition (homeostasis) at the synaptic level. However, it remains poorly understood how this imbalance (allostasis) develops in the CNS under different pain conditions. Here, we analyzed the changes in both excitat...
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Frontiers Media S.A.
2018-01-01
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Series: | Frontiers in Synaptic Neuroscience |
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Online Access: | http://journal.frontiersin.org/article/10.3389/fnsyn.2018.00001/full |
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doaj-0184b18eac504b0289d775357887ca54 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rui-Rui Wang Rui-Rui Wang Yan Wang Yan Wang Su-Min Guan Zhen Li Zhen Li Saurabh Kokane Fa-Le Cao Wei Sun Wei Sun Chun-Li Li Chun-Li Li Ting He Ting He Yan Yang Yan Yang Qing Lin Jun Chen Jun Chen Jun Chen |
spellingShingle |
Rui-Rui Wang Rui-Rui Wang Yan Wang Yan Wang Su-Min Guan Zhen Li Zhen Li Saurabh Kokane Fa-Le Cao Wei Sun Wei Sun Chun-Li Li Chun-Li Li Ting He Ting He Yan Yang Yan Yang Qing Lin Jun Chen Jun Chen Jun Chen Synaptic Homeostasis and Allostasis in the Dentate Gyrus Caused by Inflammatory and Neuropathic Pain Conditions Frontiers in Synaptic Neuroscience synaptic homeostasis and allostasis inflammatory pain neuropathic pain dentate gyrus excitatory synaptic transmission inhibitory synaptic modulation |
author_facet |
Rui-Rui Wang Rui-Rui Wang Yan Wang Yan Wang Su-Min Guan Zhen Li Zhen Li Saurabh Kokane Fa-Le Cao Wei Sun Wei Sun Chun-Li Li Chun-Li Li Ting He Ting He Yan Yang Yan Yang Qing Lin Jun Chen Jun Chen Jun Chen |
author_sort |
Rui-Rui Wang |
title |
Synaptic Homeostasis and Allostasis in the Dentate Gyrus Caused by Inflammatory and Neuropathic Pain Conditions |
title_short |
Synaptic Homeostasis and Allostasis in the Dentate Gyrus Caused by Inflammatory and Neuropathic Pain Conditions |
title_full |
Synaptic Homeostasis and Allostasis in the Dentate Gyrus Caused by Inflammatory and Neuropathic Pain Conditions |
title_fullStr |
Synaptic Homeostasis and Allostasis in the Dentate Gyrus Caused by Inflammatory and Neuropathic Pain Conditions |
title_full_unstemmed |
Synaptic Homeostasis and Allostasis in the Dentate Gyrus Caused by Inflammatory and Neuropathic Pain Conditions |
title_sort |
synaptic homeostasis and allostasis in the dentate gyrus caused by inflammatory and neuropathic pain conditions |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Synaptic Neuroscience |
issn |
1663-3563 |
publishDate |
2018-01-01 |
description |
It has been generally accepted that pain can cause imbalance between excitation and inhibition (homeostasis) at the synaptic level. However, it remains poorly understood how this imbalance (allostasis) develops in the CNS under different pain conditions. Here, we analyzed the changes in both excitatory and inhibitory synaptic transmission and modulation of the dentate gyrus (DG) under two pain conditions with different etiology and duration. First, it was revealed that the functions of the input-output (I/O) curves for evoked excitatory postsynaptic currents (eEPSCs) following the perforant path (PP) stimulation were gained under both acute inflammatory and chronic neuropathic pain conditions relative to the controls. However, the functions of I/O curves for the PP-evoked inhibitory postsynaptic currents (eIPSCs) differed between the two conditions, namely it was greatly gained under inflammatory condition, but was reduced under neuropathic condition in reverse. Second, both the frequency and amplitude of miniature IPSCs (mIPSCs) were increased under inflammatory condition, however a decrease in frequency of mIPSCs was observed under neuropathic condition. Finally, the spike discharge of the DG granule cells in response to current injection was significantly increased by neuropathic pain condition, however, no different change was found between inflammatory pain condition and the control. These results provide another line of evidence showing homeostatic and allostatic modulation of excitatory synaptic transmission by inhibitory controls under different pathological pain conditions, hence implicating use of different therapeutic approaches to maintain the homeostasis between excitation and inhibition while treating different conditions of pathological pain. |
topic |
synaptic homeostasis and allostasis inflammatory pain neuropathic pain dentate gyrus excitatory synaptic transmission inhibitory synaptic modulation |
url |
http://journal.frontiersin.org/article/10.3389/fnsyn.2018.00001/full |
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doaj-0184b18eac504b0289d775357887ca542020-11-24T21:12:09ZengFrontiers Media S.A.Frontiers in Synaptic Neuroscience1663-35632018-01-011010.3389/fnsyn.2018.00001324516Synaptic Homeostasis and Allostasis in the Dentate Gyrus Caused by Inflammatory and Neuropathic Pain ConditionsRui-Rui Wang0Rui-Rui Wang1Yan Wang2Yan Wang3Su-Min Guan4Zhen Li5Zhen Li6Saurabh Kokane7Fa-Le Cao8Wei Sun9Wei Sun10Chun-Li Li11Chun-Li Li12Ting He13Ting He14Yan Yang15Yan Yang16Qing Lin17Jun Chen18Jun Chen19Jun Chen20Institute for Biomedical Sciences of Pain, Tangdu Hospital, The Fourth Military Medical University, Xi’an, ChinaKey Laboratory of Brain Stress and Behavior, People’s Liberation Army, Xi’an, ChinaInstitute for Biomedical Sciences of Pain, Tangdu Hospital, The Fourth Military Medical University, Xi’an, ChinaKey Laboratory of Brain Stress and Behavior, People’s Liberation Army, Xi’an, ChinaSchool of Stomatology, The Fourth Military Medical University, Xi’an, ChinaInstitute for Biomedical Sciences of Pain, Tangdu Hospital, The Fourth Military Medical University, Xi’an, ChinaKey Laboratory of Brain Stress and Behavior, People’s Liberation Army, Xi’an, ChinaDepartment of Psychology, University of Texas at Arlington, Arlington, TX, United StatesDepartment of Neurology, The 88th Hospital of People’s Liberation Army, Tai’an, ChinaInstitute for Biomedical Sciences of Pain, Tangdu Hospital, The Fourth Military Medical University, Xi’an, ChinaKey Laboratory of Brain Stress and Behavior, People’s Liberation Army, Xi’an, ChinaInstitute for Biomedical Sciences of Pain, Tangdu Hospital, The Fourth Military Medical University, Xi’an, ChinaKey Laboratory of Brain Stress and Behavior, People’s Liberation Army, Xi’an, ChinaInstitute for Biomedical Sciences of Pain, Tangdu Hospital, The Fourth Military Medical University, Xi’an, ChinaKey Laboratory of Brain Stress and Behavior, People’s Liberation Army, Xi’an, ChinaInstitute for Biomedical Sciences of Pain, Tangdu Hospital, The Fourth Military Medical University, Xi’an, ChinaKey Laboratory of Brain Stress and Behavior, People’s Liberation Army, Xi’an, ChinaDepartment of Psychology, University of Texas at Arlington, Arlington, TX, United StatesInstitute for Biomedical Sciences of Pain, Tangdu Hospital, The Fourth Military Medical University, Xi’an, ChinaKey Laboratory of Brain Stress and Behavior, People’s Liberation Army, Xi’an, ChinaBeijing Institute for Brain Disorders, Beijing, ChinaIt has been generally accepted that pain can cause imbalance between excitation and inhibition (homeostasis) at the synaptic level. However, it remains poorly understood how this imbalance (allostasis) develops in the CNS under different pain conditions. Here, we analyzed the changes in both excitatory and inhibitory synaptic transmission and modulation of the dentate gyrus (DG) under two pain conditions with different etiology and duration. First, it was revealed that the functions of the input-output (I/O) curves for evoked excitatory postsynaptic currents (eEPSCs) following the perforant path (PP) stimulation were gained under both acute inflammatory and chronic neuropathic pain conditions relative to the controls. However, the functions of I/O curves for the PP-evoked inhibitory postsynaptic currents (eIPSCs) differed between the two conditions, namely it was greatly gained under inflammatory condition, but was reduced under neuropathic condition in reverse. Second, both the frequency and amplitude of miniature IPSCs (mIPSCs) were increased under inflammatory condition, however a decrease in frequency of mIPSCs was observed under neuropathic condition. Finally, the spike discharge of the DG granule cells in response to current injection was significantly increased by neuropathic pain condition, however, no different change was found between inflammatory pain condition and the control. These results provide another line of evidence showing homeostatic and allostatic modulation of excitatory synaptic transmission by inhibitory controls under different pathological pain conditions, hence implicating use of different therapeutic approaches to maintain the homeostasis between excitation and inhibition while treating different conditions of pathological pain.http://journal.frontiersin.org/article/10.3389/fnsyn.2018.00001/fullsynaptic homeostasis and allostasisinflammatory painneuropathic paindentate gyrusexcitatory synaptic transmissioninhibitory synaptic modulation |