Population Pharmacokinetics of Oxycodone and Metabolites in Patients with Cancer-Related Pain

Population Pharmacokinetics of Oxycodone and Metabolites in Patients with Cancer-Related Pain

Oxycodone is frequently used for treating cancer-related pain, while not much is known about the factors that influence treatment outcomes in these patients. We aim to unravel these factors by developing a population-pharmacokinetic model to assess the pharmacokinetics of oxycodone and its metabolit...

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Bibliographic Details
Main Authors: Bram C. Agema, Astrid W. Oosten, Sebastiaan D.T. Sassen, Wim J.R. Rietdijk, Carin C.D. van der Rijt, Birgit C.P. Koch, Ron H.J. Mathijssen, Stijn L.W. Koolen
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
oxycodone
opioids
pharmacokinetics
noroxycodone
noroxymorphone
modelling
Online Access:https://www.mdpi.com/2072-6694/13/11/2768

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