Exosomes: From Potential Culprits to New Therapeutic Promise in the Setting of Cardiac Fibrosis
Fibrosis is a significant global health problem associated with many inflammatory and degenerative diseases affecting multiple organs, individually or simultaneously. Fibrosis develops when extracellular matrix (ECM) remodeling becomes excessive or uncontrolled and is associated with nearly all form...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-03-01
|
Series: | Cells |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4409/9/3/592 |
id |
doaj-018cb018f9c446259682d13c059e1207 |
---|---|
record_format |
Article |
spelling |
doaj-018cb018f9c446259682d13c059e12072020-11-25T02:15:06ZengMDPI AGCells2073-44092020-03-019359210.3390/cells9030592cells9030592Exosomes: From Potential Culprits to New Therapeutic Promise in the Setting of Cardiac FibrosisRoman Tikhomirov0Benedict Reilly-O’ Donnell1Francesco Catapano2Giuseppe Faggian3Julia Gorelik4Fabio Martelli5Costanza Emanueli6National Heart and Lung Institute, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UKNational Heart and Lung Institute, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UKNational Heart and Lung Institute, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UKDepartment of Surgery, Dentistry, Pediatrics and Gynecology, Cardiovascular Science, The University of Verona, Policlinico G.B. Rossi, P.le. La Scuro 10, 37134 Verona, ItalyNational Heart and Lung Institute, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UKDepartment of Surgery, Dentistry, Pediatrics and Gynecology, Cardiovascular Science, The University of Verona, Policlinico G.B. Rossi, P.le. La Scuro 10, 37134 Verona, ItalyNational Heart and Lung Institute, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UKFibrosis is a significant global health problem associated with many inflammatory and degenerative diseases affecting multiple organs, individually or simultaneously. Fibrosis develops when extracellular matrix (ECM) remodeling becomes excessive or uncontrolled and is associated with nearly all forms of heart disease. Cardiac fibroblasts and myofibroblasts are the main effectors of ECM deposition and scar formation. The heart is a complex multicellular organ, where the various resident cell types communicate between themselves and with cells of the blood and immune systems. Exosomes, which are small extracellular vesicles, (EVs), contribute to cell-to-cell communication and their pathophysiological relevance and therapeutic potential is emerging. Here, we will critically review the role of endogenous exosomes as possible fibrosis mediators and discuss the possibility of using stem cell-derived and/or engineered exosomes as anti-fibrotic agents.https://www.mdpi.com/2073-4409/9/3/592cardiac fibrosisheart failureextracellular vesicle (evs)evs engineeringexosomesmicrornasnoncoding rnasstem cells |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Roman Tikhomirov Benedict Reilly-O’ Donnell Francesco Catapano Giuseppe Faggian Julia Gorelik Fabio Martelli Costanza Emanueli |
spellingShingle |
Roman Tikhomirov Benedict Reilly-O’ Donnell Francesco Catapano Giuseppe Faggian Julia Gorelik Fabio Martelli Costanza Emanueli Exosomes: From Potential Culprits to New Therapeutic Promise in the Setting of Cardiac Fibrosis Cells cardiac fibrosis heart failure extracellular vesicle (evs) evs engineering exosomes micrornas noncoding rnas stem cells |
author_facet |
Roman Tikhomirov Benedict Reilly-O’ Donnell Francesco Catapano Giuseppe Faggian Julia Gorelik Fabio Martelli Costanza Emanueli |
author_sort |
Roman Tikhomirov |
title |
Exosomes: From Potential Culprits to New Therapeutic Promise in the Setting of Cardiac Fibrosis |
title_short |
Exosomes: From Potential Culprits to New Therapeutic Promise in the Setting of Cardiac Fibrosis |
title_full |
Exosomes: From Potential Culprits to New Therapeutic Promise in the Setting of Cardiac Fibrosis |
title_fullStr |
Exosomes: From Potential Culprits to New Therapeutic Promise in the Setting of Cardiac Fibrosis |
title_full_unstemmed |
Exosomes: From Potential Culprits to New Therapeutic Promise in the Setting of Cardiac Fibrosis |
title_sort |
exosomes: from potential culprits to new therapeutic promise in the setting of cardiac fibrosis |
publisher |
MDPI AG |
series |
Cells |
issn |
2073-4409 |
publishDate |
2020-03-01 |
description |
Fibrosis is a significant global health problem associated with many inflammatory and degenerative diseases affecting multiple organs, individually or simultaneously. Fibrosis develops when extracellular matrix (ECM) remodeling becomes excessive or uncontrolled and is associated with nearly all forms of heart disease. Cardiac fibroblasts and myofibroblasts are the main effectors of ECM deposition and scar formation. The heart is a complex multicellular organ, where the various resident cell types communicate between themselves and with cells of the blood and immune systems. Exosomes, which are small extracellular vesicles, (EVs), contribute to cell-to-cell communication and their pathophysiological relevance and therapeutic potential is emerging. Here, we will critically review the role of endogenous exosomes as possible fibrosis mediators and discuss the possibility of using stem cell-derived and/or engineered exosomes as anti-fibrotic agents. |
topic |
cardiac fibrosis heart failure extracellular vesicle (evs) evs engineering exosomes micrornas noncoding rnas stem cells |
url |
https://www.mdpi.com/2073-4409/9/3/592 |
work_keys_str_mv |
AT romantikhomirov exosomesfrompotentialculpritstonewtherapeuticpromiseinthesettingofcardiacfibrosis AT benedictreillyodonnell exosomesfrompotentialculpritstonewtherapeuticpromiseinthesettingofcardiacfibrosis AT francescocatapano exosomesfrompotentialculpritstonewtherapeuticpromiseinthesettingofcardiacfibrosis AT giuseppefaggian exosomesfrompotentialculpritstonewtherapeuticpromiseinthesettingofcardiacfibrosis AT juliagorelik exosomesfrompotentialculpritstonewtherapeuticpromiseinthesettingofcardiacfibrosis AT fabiomartelli exosomesfrompotentialculpritstonewtherapeuticpromiseinthesettingofcardiacfibrosis AT costanzaemanueli exosomesfrompotentialculpritstonewtherapeuticpromiseinthesettingofcardiacfibrosis |
_version_ |
1724897791003590656 |