ST2 IN REJECTION OF THE TRANSPLANTED HEART

• Main Authors: O. P. Shevchenko, A. A. Ulybysheva, D. A. Velikiy, A. O. Shevchenko
• Format: Article
• Language: Russian
• Published: Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov 2016-01-01
• Series: Vestnik Transplantologii i Iskusstvennyh Organov
• Subjects: heart transplantation; st2; heart failure; rejection
• Online Access: https://journal.transpl.ru/vtio/article/view/595

This review summarizes the current literature devoted to the analysis of prognostic role of ST2 biomarker in rejection of the transplanted heart. ST2 is one of the most promising diagnostic markers of the development and severity of heart failure as well as the mortality risk in patients with cardiovascular diseases. ST2 is expressed in cardiomyocytes in response to a variety of pathological processes and mechanical damage to the heart, which allows diagnosing cardiovascular diseases before clinical manifestations. Presumably, measuring the level of ST2 in heart transplant may have diagnostic and prognostic value in the assessment of graft and risk of rejection. Currently, accumulated clinical data on the role of given biomarker in heart transplantation are not enough, and further research on the relation of ST2 levels with different clinical and laboratory parameters in heart recipients is necessary.