Depression in Parkinson's disease: A case-control study.

To evaluate the association between Parkinson's disease (PD) prognosis and the patient's onset of depression.A total of 353 patients with newly-diagnosed PD and a history of depression were enrolled. On the basis of the onset of depression before or after PD diagnosis, we divided participa...

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Main Authors: Yu-Hsuan Wu, Yi-Huei Chen, Ming-Hong Chang, Ching-Heng Lin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5794149?pdf=render
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spelling doaj-019caf7e9d574d0ba67b080ce44ec5b12020-11-24T22:17:52ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01132e019205010.1371/journal.pone.0192050Depression in Parkinson's disease: A case-control study.Yu-Hsuan WuYi-Huei ChenMing-Hong ChangChing-Heng LinTo evaluate the association between Parkinson's disease (PD) prognosis and the patient's onset of depression.A total of 353 patients with newly-diagnosed PD and a history of depression were enrolled. On the basis of the onset of depression before or after PD diagnosis, we divided participants into PD patients with pre- or post-diagnostic depression. Cox's regression analysis was used to detect risks between the onset of depression and outcomes (including death, accidental injury, dementia, and aspiration pneumonia). The association between the onset of depression and levodopa equivalent dosage (LED) and cumulative equivalent dosage of antidepressants were assessed.PD patients with post-diagnostic depression were associated with significantly higher risks of dementia (adjusted HR = 2·01, p = 0·015), and were older (58·5 ± 17·7 vs. 53·7 ± 18·6, p = 0·020) at the time of PD diagnosis than PD patients with pre-diagnostic depression. The higher incident rate of accidental injury was also noted in PD patients with post-diagnostic depression (48·1 vs. 31·3/1000 person-years, HR = 1·60, p = 0·041), but no statistical significance was observed in the adjusted hazard ratio (HR) (HR = 1·52, p = 0·069). Otherwise, mortality, motor condition and severity of depression revealed no significant difference between PD patients with pre-diagnostic and post-diagnostic depression.PD patients with post-diagnostic depression had higher incidence of dementia, implying different onset time of depression could be associated with different subtypes and spreading routes which should be examined in follow-up studies.http://europepmc.org/articles/PMC5794149?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Yu-Hsuan Wu
Yi-Huei Chen
Ming-Hong Chang
Ching-Heng Lin
spellingShingle Yu-Hsuan Wu
Yi-Huei Chen
Ming-Hong Chang
Ching-Heng Lin
Depression in Parkinson's disease: A case-control study.
PLoS ONE
author_facet Yu-Hsuan Wu
Yi-Huei Chen
Ming-Hong Chang
Ching-Heng Lin
author_sort Yu-Hsuan Wu
title Depression in Parkinson's disease: A case-control study.
title_short Depression in Parkinson's disease: A case-control study.
title_full Depression in Parkinson's disease: A case-control study.
title_fullStr Depression in Parkinson's disease: A case-control study.
title_full_unstemmed Depression in Parkinson's disease: A case-control study.
title_sort depression in parkinson's disease: a case-control study.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2018-01-01
description To evaluate the association between Parkinson's disease (PD) prognosis and the patient's onset of depression.A total of 353 patients with newly-diagnosed PD and a history of depression were enrolled. On the basis of the onset of depression before or after PD diagnosis, we divided participants into PD patients with pre- or post-diagnostic depression. Cox's regression analysis was used to detect risks between the onset of depression and outcomes (including death, accidental injury, dementia, and aspiration pneumonia). The association between the onset of depression and levodopa equivalent dosage (LED) and cumulative equivalent dosage of antidepressants were assessed.PD patients with post-diagnostic depression were associated with significantly higher risks of dementia (adjusted HR = 2·01, p = 0·015), and were older (58·5 ± 17·7 vs. 53·7 ± 18·6, p = 0·020) at the time of PD diagnosis than PD patients with pre-diagnostic depression. The higher incident rate of accidental injury was also noted in PD patients with post-diagnostic depression (48·1 vs. 31·3/1000 person-years, HR = 1·60, p = 0·041), but no statistical significance was observed in the adjusted hazard ratio (HR) (HR = 1·52, p = 0·069). Otherwise, mortality, motor condition and severity of depression revealed no significant difference between PD patients with pre-diagnostic and post-diagnostic depression.PD patients with post-diagnostic depression had higher incidence of dementia, implying different onset time of depression could be associated with different subtypes and spreading routes which should be examined in follow-up studies.
url http://europepmc.org/articles/PMC5794149?pdf=render
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AT yihueichen depressioninparkinsonsdiseaseacasecontrolstudy
AT minghongchang depressioninparkinsonsdiseaseacasecontrolstudy
AT chinghenglin depressioninparkinsonsdiseaseacasecontrolstudy
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