Targeting VEGF pathway to normalize the vasculature: an emerging insight in cancer therapy
Jing-biao Wu, Ya-ling Tang, Xin-hua Liang State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan, People’s Republic of China Abstract: Vascular normalization is a new concept of ta...
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doaj-01a3464c6e934ca08a44b696c0ecb1732020-11-25T00:44:40ZengDove Medical PressOncoTargets and Therapy1178-69302018-10-01Volume 116901690941525Targeting VEGF pathway to normalize the vasculature: an emerging insight in cancer therapyWu JTang YLiang XJing-biao Wu, Ya-ling Tang, Xin-hua Liang State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan, People’s Republic of China Abstract: Vascular normalization is a new concept of targeting angiogenesis to restore vessel structure and function and to increase blood perfusion and delivery of drugs. It has been confirmed that vascular normalization can decrease relapse and benefit other cancer therapy, including chemotherapy, radiotherapy, and immune cell therapy. The key point of this therapy is to inhibit pro-angiogenic factors and make it be balanced with anti-angiogenic factors, resulting in a mature and normal vessel characteristic. Vascular endothelial growth factor (VEGF) is a key player in the process of tumor angiogenesis, and inhibiting VEGF is a primary approach to tumor vessel normalization. Herein, we review newly uncovered mechanisms governing angiogenesis and vascular normalization of cancer and place emphasis on targeting VEGF pathway to normalize the vasculature. Also, important methods to depress VEGF pathway and make tumor vascular are discussed. Keywords: vascular normalization, vascular endothelial growth factor (VEGF), anti-angiogenesis, treatment resistance, cancer therapyhttps://www.dovepress.com/targeting-vegf-pathway-to-normalize-the-vasculature-an-emerging-insigh-peer-reviewed-article-OTTvascular normalizationvascular endothelial growth factor (VEGF)anti-angiogenesistreatment resistance,cancer therapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wu J Tang Y Liang X |
spellingShingle |
Wu J Tang Y Liang X Targeting VEGF pathway to normalize the vasculature: an emerging insight in cancer therapy OncoTargets and Therapy vascular normalization vascular endothelial growth factor (VEGF) anti-angiogenesis treatment resistance,cancer therapy |
author_facet |
Wu J Tang Y Liang X |
author_sort |
Wu J |
title |
Targeting VEGF pathway to normalize the vasculature: an emerging insight in cancer therapy |
title_short |
Targeting VEGF pathway to normalize the vasculature: an emerging insight in cancer therapy |
title_full |
Targeting VEGF pathway to normalize the vasculature: an emerging insight in cancer therapy |
title_fullStr |
Targeting VEGF pathway to normalize the vasculature: an emerging insight in cancer therapy |
title_full_unstemmed |
Targeting VEGF pathway to normalize the vasculature: an emerging insight in cancer therapy |
title_sort |
targeting vegf pathway to normalize the vasculature: an emerging insight in cancer therapy |
publisher |
Dove Medical Press |
series |
OncoTargets and Therapy |
issn |
1178-6930 |
publishDate |
2018-10-01 |
description |
Jing-biao Wu, Ya-ling Tang, Xin-hua Liang State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan, People’s Republic of China Abstract: Vascular normalization is a new concept of targeting angiogenesis to restore vessel structure and function and to increase blood perfusion and delivery of drugs. It has been confirmed that vascular normalization can decrease relapse and benefit other cancer therapy, including chemotherapy, radiotherapy, and immune cell therapy. The key point of this therapy is to inhibit pro-angiogenic factors and make it be balanced with anti-angiogenic factors, resulting in a mature and normal vessel characteristic. Vascular endothelial growth factor (VEGF) is a key player in the process of tumor angiogenesis, and inhibiting VEGF is a primary approach to tumor vessel normalization. Herein, we review newly uncovered mechanisms governing angiogenesis and vascular normalization of cancer and place emphasis on targeting VEGF pathway to normalize the vasculature. Also, important methods to depress VEGF pathway and make tumor vascular are discussed. Keywords: vascular normalization, vascular endothelial growth factor (VEGF), anti-angiogenesis, treatment resistance, cancer therapy |
topic |
vascular normalization vascular endothelial growth factor (VEGF) anti-angiogenesis treatment resistance,cancer therapy |
url |
https://www.dovepress.com/targeting-vegf-pathway-to-normalize-the-vasculature-an-emerging-insigh-peer-reviewed-article-OTT |
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1725274197500887040 |