The Multi-Targeting Ligand ST-2223 with Histamine H<sub>3</sub>Receptor and Dopamine D<sub>2</sub>/D<sub>3</sub> Receptor Antagonist Properties Mitigates Autism-Like Repetitive Behaviors and BrainOxidative Stress in Mice

The Multi-Targeting Ligand ST-2223 with Histamine H<sub>3</sub>Receptor and Dopamine D<sub>2</sub>/D<sub>3</sub> Receptor Antagonist Properties Mitigates Autism-Like Repetitive Behaviors and BrainOxidative Stress in Mice

Autism spectrum disorder (ASD) is a complex heterogeneous neurodevelopmental disorder characterized by social and communicative impairments, as well as repetitive and restricted behaviors (RRBs). With the limited effectiveness of current pharmacotherapies in treating repetitive behaviors, the presen...

Full description

Bibliographic Details
Main Authors: Nermin Eissa, Karthikkumar Venkatachalam, Petrilla Jayaprakash, Markus Falkenstein, Mariam Dubiel, Annika Frank, David Reiner-Link, Holger Stark, Bassem Sadek
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
autistic spectrum disorder
BTBR mice
histamine H<sub>3</sub> receptor antagonist
dopamine D<sub>2</sub>/D<sub>3</sub>R antagonist
repetitive and restricted behavior
anxiety
Online Access:https://www.mdpi.com/1422-0067/22/4/1947

Internet

https://www.mdpi.com/1422-0067/22/4/1947

Similar Items