Anti-cyclic citrullinated peptide antibodies – a role in rheumatoid arthritis and the possibility of seroconversion: A focus on abatacept
The detection of anti-cyclic citrullinated peptide (anti-CCP) antibodies plays a diagnostic and statistical predictive role in rheumatoid arthritis (RA). The decreased concentration of anti-CCP antibodies or their seroconversion is observed for not all groups of anti-inflammatory drugs. Seropositivi...
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2017-03-01
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| Series: | Современная ревматология |
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| Online Access: | https://mrj.ima-press.net/mrj/article/view/743 |
| Summary: | The detection of anti-cyclic citrullinated peptide (anti-CCP) antibodies plays a diagnostic and statistical predictive role in rheumatoid arthritis (RA). The decreased concentration of anti-CCP antibodies or their seroconversion is observed for not all groups of anti-inflammatory drugs. Seropositivity for anti-CCP antibodies is a predictor of the higher efficacy of abatacept (ABC). The possibility of seroconversion of anti-CCP antibodies, like rheumatoid factor, during treatment with ABC is associated with the more pronounced suppression of clinical symptoms of RA activity and progressive joint destruction, with remission achievement in a large proportion of patients. |
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| ISSN: | 1996-7012 2310-158X |