Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism
Endometriosis is a major cause of infertility. Molecular mechanisms underlying the disease involve genetic and environmental risk factors. In a meta-analysis of eleven GWA studies, Sapkota and colleagues identify five novel risk loci, implicating steroid sex hormone pathways in the pathogenesis.
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Nature Publishing Group
2017-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms15539 |
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doaj-01ad40bb5e464263812572052ae10cf62021-05-11T07:24:31ZengNature Publishing GroupNature Communications2041-17232017-05-018111210.1038/ncomms15539Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolismYadav Sapkota0Valgerdur Steinthorsdottir1Andrew P. Morris2Amelie Fassbender3Nilufer Rahmioglu4Immaculata De Vivo5Julie E. Buring6Futao Zhang7Todd L. Edwards8Sarah Jones9Dorien O10Daniëlle Peterse11Kathryn M. Rexrode12Paul M. Ridker13Andrew J. Schork14Stuart MacGregor15Nicholas G. Martin16Christian M. Becker17Sosuke Adachi18Kosuke Yoshihara19Takayuki Enomoto20Atsushi Takahashi21Yoichiro Kamatani22Koichi Matsuda23Michiaki Kubo24Gudmar Thorleifsson25Reynir T. Geirsson26Unnur Thorsteinsdottir27Leanne M. Wallace28iPSYCH-SSI-Broad GroupJian Yang29Digna R. Velez Edwards30Mette Nyegaard31Siew-Kee Low32Krina T. Zondervan33Stacey A. Missmer34Thomas D'Hooghe35Grant W. Montgomery36Daniel I. Chasman37Kari Stefansson38Joyce Y. Tung39Dale R. Nyholt40Department of Genetics and Computational Biology, QIMR Berghofer Medical Research InstitutedeCODE Genetics/Amgen, 101Department of Biostatistics, University of LiverpoolDepartment of Development and Regeneration, KULeuven, Organ systemsWellcome Trust Centre for Human Genetics, University of OxfordHarvard T.H. Chan School of Public HealthHarvard T.H. Chan School of Public HealthInstitute for Molecular Bioscience, The University of QueenslandInstitute of Medicine and Public Health, Vanderbilt University Medical CenterDivision of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Institute of Medicine and Public Health, Vanderbilt University Medical CenterDepartment of Development and Regeneration, KULeuven, Organ systemsDepartment of Development and Regeneration, KULeuven, Organ systemsHarvard T.H. Chan School of Public HealthHarvard T.H. Chan School of Public HealthCognitive Science Department, University of CaliforniaDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research InstituteDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research InstituteEndometriosis CaRe Centre, Nuffield Dept of Obstetrics & Gynaecology, University of Oxford, John Radcliffe HospitalDepartment of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental SciencesDepartment of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental SciencesDepartment of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental SciencesCenter for Integrative Medical Sciences, RIKENCenter for Integrative Medical Sciences, RIKENInstitute of Medical Sciences, The University of TokyoCenter for Integrative Medical Sciences, RIKENdeCODE Genetics/Amgen, 101Department of Obstetrics and Gynecology, Landspitali University HospitaldeCODE Genetics/Amgen, 101Department of Genetics and Computational Biology, QIMR Berghofer Medical Research InstituteInstitute for Molecular Bioscience, The University of QueenslandDepartment of Obstetrics and Gynecology, Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Institute of Medicine and Public Health, Vanderbilt University Medical CenterDepartment of Biomedicine, Aarhus UniversityCenter for Integrative Medical Sciences, RIKENWellcome Trust Centre for Human Genetics, University of OxfordHarvard T.H. Chan School of Public HealthDepartment of Development and Regeneration, KULeuven, Organ systemsDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research InstituteHarvard T.H. Chan School of Public HealthdeCODE Genetics/Amgen, 10123andMe, Inc.Department of Genetics and Computational Biology, QIMR Berghofer Medical Research InstituteEndometriosis is a major cause of infertility. Molecular mechanisms underlying the disease involve genetic and environmental risk factors. In a meta-analysis of eleven GWA studies, Sapkota and colleagues identify five novel risk loci, implicating steroid sex hormone pathways in the pathogenesis.https://doi.org/10.1038/ncomms15539 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Yadav Sapkota Valgerdur Steinthorsdottir Andrew P. Morris Amelie Fassbender Nilufer Rahmioglu Immaculata De Vivo Julie E. Buring Futao Zhang Todd L. Edwards Sarah Jones Dorien O Daniëlle Peterse Kathryn M. Rexrode Paul M. Ridker Andrew J. Schork Stuart MacGregor Nicholas G. Martin Christian M. Becker Sosuke Adachi Kosuke Yoshihara Takayuki Enomoto Atsushi Takahashi Yoichiro Kamatani Koichi Matsuda Michiaki Kubo Gudmar Thorleifsson Reynir T. Geirsson Unnur Thorsteinsdottir Leanne M. Wallace iPSYCH-SSI-Broad Group Jian Yang Digna R. Velez Edwards Mette Nyegaard Siew-Kee Low Krina T. Zondervan Stacey A. Missmer Thomas D'Hooghe Grant W. Montgomery Daniel I. Chasman Kari Stefansson Joyce Y. Tung Dale R. Nyholt |
| spellingShingle |
Yadav Sapkota Valgerdur Steinthorsdottir Andrew P. Morris Amelie Fassbender Nilufer Rahmioglu Immaculata De Vivo Julie E. Buring Futao Zhang Todd L. Edwards Sarah Jones Dorien O Daniëlle Peterse Kathryn M. Rexrode Paul M. Ridker Andrew J. Schork Stuart MacGregor Nicholas G. Martin Christian M. Becker Sosuke Adachi Kosuke Yoshihara Takayuki Enomoto Atsushi Takahashi Yoichiro Kamatani Koichi Matsuda Michiaki Kubo Gudmar Thorleifsson Reynir T. Geirsson Unnur Thorsteinsdottir Leanne M. Wallace iPSYCH-SSI-Broad Group Jian Yang Digna R. Velez Edwards Mette Nyegaard Siew-Kee Low Krina T. Zondervan Stacey A. Missmer Thomas D'Hooghe Grant W. Montgomery Daniel I. Chasman Kari Stefansson Joyce Y. Tung Dale R. Nyholt Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism Nature Communications |
| author_facet |
Yadav Sapkota Valgerdur Steinthorsdottir Andrew P. Morris Amelie Fassbender Nilufer Rahmioglu Immaculata De Vivo Julie E. Buring Futao Zhang Todd L. Edwards Sarah Jones Dorien O Daniëlle Peterse Kathryn M. Rexrode Paul M. Ridker Andrew J. Schork Stuart MacGregor Nicholas G. Martin Christian M. Becker Sosuke Adachi Kosuke Yoshihara Takayuki Enomoto Atsushi Takahashi Yoichiro Kamatani Koichi Matsuda Michiaki Kubo Gudmar Thorleifsson Reynir T. Geirsson Unnur Thorsteinsdottir Leanne M. Wallace iPSYCH-SSI-Broad Group Jian Yang Digna R. Velez Edwards Mette Nyegaard Siew-Kee Low Krina T. Zondervan Stacey A. Missmer Thomas D'Hooghe Grant W. Montgomery Daniel I. Chasman Kari Stefansson Joyce Y. Tung Dale R. Nyholt |
| author_sort |
Yadav Sapkota |
| title |
Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism |
| title_short |
Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism |
| title_full |
Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism |
| title_fullStr |
Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism |
| title_full_unstemmed |
Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism |
| title_sort |
meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-05-01 |
| description |
Endometriosis is a major cause of infertility. Molecular mechanisms underlying the disease involve genetic and environmental risk factors. In a meta-analysis of eleven GWA studies, Sapkota and colleagues identify five novel risk loci, implicating steroid sex hormone pathways in the pathogenesis. |
| url |
https://doi.org/10.1038/ncomms15539 |
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