Enantioselective supramolecular devices in the gas phase. Resorcin[4]arene as a model system

Enantioselective supramolecular devices in the gas phase. Resorcin[4]arene as a model system

This review describes the state-of-art in the field of the gas-phase reactivity of diastereomeric complexes formed between a chiral artificial receptor and a biologically active molecule. The presented experimental approach is a ligand-displacement reaction carried out in a nano ESI-FT-ICR instrumen...

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Bibliographic Details
Main Authors: Caterina Fraschetti, Matthias C. Letzel, Antonello Filippi, Maurizio Speranza, Jochen Mattay
Format: Article
Language:English
Published: Beilstein-Institut 2012-04-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
diastereomeric complexes
gas phase enantioselectivity
kinetics
mass spectrometry
resorcin[4]arene receptor
Online Access:https://doi.org/10.3762/bjoc.8.62
Description
Summary:This review describes the state-of-art in the field of the gas-phase reactivity of diastereomeric complexes formed between a chiral artificial receptor and a biologically active molecule. The presented experimental approach is a ligand-displacement reaction carried out in a nano ESI-FT-ICR instrument, supported by a thermodynamic MS-study and molecular-mechanics and molecular-dynamics (MM/MD) computational techniques. The noncovalent ion–molecule complexes are ideal for the study of chiral recognition in the absence of complicating solvent and counterion effects.
ISSN:1860-5397

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