Serum biomarkers in patients with stable and acute exacerbation of chronic obstructive pulmonary disease: A comparative study

• Main Authors: Şahin Füsun, Filiz-Koşar Ayşe, Feyza-Aslan Ayşe, Yigitbaş Burcu, Uslu Berat
• Format: Article
• Language: English
• Published: Society of Medical Biochemists of Serbia, Belgrade 2019-01-01
• Series: Journal of Medical Biochemistry
• Subjects: copd; neutrophil/lymphocyte ratio; platelet/ lymphocyte ratio; inflammatory biomarkers
• Online Access: https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2019/1452-82581904503Q.pdf
• ISSN: 1452-8258; 1452-8266

Background: Mean platelet volume (MPV), neutrophil-tolymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have all been investigated as novel inflammatory markers of cardiac and oncological diseases, while there is only a limited number of studies investigating these markers in chronic obstructive pulmonary disease (COPD). In the present study we examine NLR, PLR; and other markers, such as eosinophil, MPV, plateletcrit (PCT), platelet distribution width (PDW), red cell distribution width (RDW), and C-reactive protein (CRP) in patients with stable and acute exacerbation of COPD. Methods: Stable COPD (Group 1, n=140), COPD with acute exacerbation (Group 2, n=110), and healthy controls (Group 3, n=50) were included in the study. Leukocyte, CRP hemoglobin (HB), RDW, platelet, MPV, PCT, PDW, neutrophil, lymphocyte, eosinophil, NLR, and PLR were analyzed in all groups. Results: HB, leukocyte, platelet, neutrophil, eosinophil, MPV, PCT, CRP NLR, and PLR were significantly higher, while the lymphocyte was lower in Group 1 than in Group 3. Leukocyte, neutrophil, RDW, CRP n Lr , and PLR were significantly higher, while lymphocyte was lower in Group 2 than in Group 3. Leukocyte, neutrophil, RDW, CRP NLR, and PLR were significantly higher, while HB, platelet, MPV, PCT, and lymphocyte were significantly lower in Group 2 than in Group 1. NLR and PLR increased significantly in patients with bronchiectasis when compared to those without in Group 1. Conclusions: Our study results suggest that NLR, PLR and RDW can be used as simple and cost-effective markers for the evaluation of severity of exacerbation and for predicting hospitalization and further exacerbations in patients with COPD.