Deep Brain Stimulation in Moroccan Patients With Parkinson's Disease: The Experience of Neurology Department of Rabat
Introduction: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is known as a therapy of choice of advanced Parkinson's disease. The present study aimed to assess the beneficial and side effects of STN DBS in Moroccan Parkinsonian patients.Material and Methods: Thirty five patients...
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Frontiers Media S.A.
2018-07-01
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Series: | Frontiers in Neurology |
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Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2018.00532/full |
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language |
English |
format |
Article |
sources |
DOAJ |
author |
Mounia Rahmani Maria Benabdeljlil Fouad Bellakhdar Mustapha El Alaoui Faris Mohamed Jiddane Khalil El Bayad Fatima Boutbib Rachid Razine Rachid Gana Moulay R. El Hassani Nizar El Fatemi Meryem Fikri Siham Sanhaji Hennou Tassine Imane El Alaoui Balrhiti Souad El Hadri Najwa Ech-Cherif Kettani Najia El Abbadi Mourad Amor Abdelmjid Moussaoui Afifa Semlali Saadia Aidi El Hachmia Ait Benhaddou Ali Benomar Ahmed Bouhouche Mohamed Yahyaoui Abdeslam El Khamlichi Abdessamad El Ouahabi Rachid El Maaqili Houyam Tibar Yasser Arkha Adyl Melhaoui Abdelhamid Benazzouz Wafa Regragui |
spellingShingle |
Mounia Rahmani Maria Benabdeljlil Fouad Bellakhdar Mustapha El Alaoui Faris Mohamed Jiddane Khalil El Bayad Fatima Boutbib Rachid Razine Rachid Gana Moulay R. El Hassani Nizar El Fatemi Meryem Fikri Siham Sanhaji Hennou Tassine Imane El Alaoui Balrhiti Souad El Hadri Najwa Ech-Cherif Kettani Najia El Abbadi Mourad Amor Abdelmjid Moussaoui Afifa Semlali Saadia Aidi El Hachmia Ait Benhaddou Ali Benomar Ahmed Bouhouche Mohamed Yahyaoui Abdeslam El Khamlichi Abdessamad El Ouahabi Rachid El Maaqili Houyam Tibar Yasser Arkha Adyl Melhaoui Abdelhamid Benazzouz Wafa Regragui Deep Brain Stimulation in Moroccan Patients With Parkinson's Disease: The Experience of Neurology Department of Rabat Frontiers in Neurology Parkinson disease deep brain stimulation subthalamic nucleus quality of life surgical benefit clinical outcome |
author_facet |
Mounia Rahmani Maria Benabdeljlil Fouad Bellakhdar Mustapha El Alaoui Faris Mohamed Jiddane Khalil El Bayad Fatima Boutbib Rachid Razine Rachid Gana Moulay R. El Hassani Nizar El Fatemi Meryem Fikri Siham Sanhaji Hennou Tassine Imane El Alaoui Balrhiti Souad El Hadri Najwa Ech-Cherif Kettani Najia El Abbadi Mourad Amor Abdelmjid Moussaoui Afifa Semlali Saadia Aidi El Hachmia Ait Benhaddou Ali Benomar Ahmed Bouhouche Mohamed Yahyaoui Abdeslam El Khamlichi Abdessamad El Ouahabi Rachid El Maaqili Houyam Tibar Yasser Arkha Adyl Melhaoui Abdelhamid Benazzouz Wafa Regragui |
author_sort |
Mounia Rahmani |
title |
Deep Brain Stimulation in Moroccan Patients With Parkinson's Disease: The Experience of Neurology Department of Rabat |
title_short |
Deep Brain Stimulation in Moroccan Patients With Parkinson's Disease: The Experience of Neurology Department of Rabat |
title_full |
Deep Brain Stimulation in Moroccan Patients With Parkinson's Disease: The Experience of Neurology Department of Rabat |
title_fullStr |
Deep Brain Stimulation in Moroccan Patients With Parkinson's Disease: The Experience of Neurology Department of Rabat |
title_full_unstemmed |
Deep Brain Stimulation in Moroccan Patients With Parkinson's Disease: The Experience of Neurology Department of Rabat |
title_sort |
deep brain stimulation in moroccan patients with parkinson's disease: the experience of neurology department of rabat |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2018-07-01 |
description |
Introduction: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is known as a therapy of choice of advanced Parkinson's disease. The present study aimed to assess the beneficial and side effects of STN DBS in Moroccan Parkinsonian patients.Material and Methods: Thirty five patients underwent bilateral STN DBS from 2008 to 2016 in the Rabat University Hospital. Patients were assessed preoperatively and followed up for 6 to 12 months using the Unified Parkinson's Disease Rating Scale in four conditions (stimulation OFF and ON and medication OFF and ON), the levodopa-equivalent daily dose (LEDD), dyskinesia and fluctuation scores and PDQ39 scale for quality of life (QOL). Postoperative side effects were also recorded.Results: The mean age at disease onset was 42.31 ± 7.29 years [28–58] and the mean age at surgery was 54.66 ± 8.51 years [34–70]. The median disease duration was 11.95 ± 4.28 years [5–22]. Sixty-three percentage of patients were male. 11.4% of patients were tremor dominant while 45.71 showed akinetic-rigid form and 42.90 were classified as mixed phenotype. The LEDD before surgery was 1200 mg/day [800-1500]. All patients had motor fluctuations whereas non-motor fluctuations were present in 61.80% of cases. STN DBS decreased the LEDD by 51.72%, as the mean LEDD post-surgery was 450 [188-800]. The UPDRS-III was improved by 52.27%, dyskinesia score by 66.70% and motor fluctuations by 50%, whereas QOL improved by 27.12%. Post-operative side effects were hypophonia (2 cases), infection (3 cases), and pneumocephalus (2 cases).Conclusion: Our results showed that STN DBS is an effective treatment in Moroccan Parkinsonian patients leading to a major improvement of the most disabling symptoms (dyskinesia, motor fluctuation) and a better QOL. |
topic |
Parkinson disease deep brain stimulation subthalamic nucleus quality of life surgical benefit clinical outcome |
url |
https://www.frontiersin.org/article/10.3389/fneur.2018.00532/full |
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doaj-01c2d0a03d95451fb4dc0bf8d3def84d2020-11-25T00:50:51ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-07-01910.3389/fneur.2018.00532316253Deep Brain Stimulation in Moroccan Patients With Parkinson's Disease: The Experience of Neurology Department of RabatMounia Rahmani0Maria Benabdeljlil1Fouad Bellakhdar2Mustapha El Alaoui Faris3Mohamed Jiddane4Khalil El Bayad5Fatima Boutbib6Rachid Razine7Rachid Gana8Moulay R. El Hassani9Nizar El Fatemi10Meryem Fikri11Siham Sanhaji12Hennou Tassine13Imane El Alaoui Balrhiti14Souad El Hadri15Najwa Ech-Cherif Kettani16Najia El Abbadi17Mourad Amor18Abdelmjid Moussaoui19Afifa Semlali20Saadia Aidi21El Hachmia Ait Benhaddou22Ali Benomar23Ahmed Bouhouche24Mohamed Yahyaoui25Abdeslam El Khamlichi26Abdessamad El Ouahabi27Rachid El Maaqili28Houyam Tibar29Yasser Arkha30Adyl Melhaoui31Abdelhamid Benazzouz32Wafa Regragui33Research Team in Neurology and Neurogenetics, Department of Neurology A and Neuropsychology, Faculty of Medicine and Pharmacy, Hôpital des Spécialités ONO, University Mohammed V, Rabat, MoroccoResearch Team in Neurology and Neurogenetics, Department of Neurology A and Neuropsychology, Faculty of Medicine and Pharmacy, Hôpital des Spécialités ONO, University Mohammed V, Rabat, MoroccoDepartment of Neurosurgery, Faculty of Medicine and Pharmacy, Hôpital Ibn Sina, University Mohammed V, Rabat, MoroccoResearch Team in Neurology and Neurogenetics, Department of Neurology A and Neuropsychology, Faculty of Medicine and Pharmacy, Hôpital des Spécialités ONO, University Mohammed V, Rabat, MoroccoDepartment of Neuroradiology, Faculty of Medicine and Pharmacy, Hôpital des Spécialités ONO, University Mohammed V, Rabat, MoroccoResearch Team in Neurology and Neurogenetics, Department of Neurology B and Neurogenetics, Faculty of Medicine and Pharmacy, Hôpital des Spécialités ONO, University Mohammed V, Rabat, MoroccoResearch Team in Neurology and Neurogenetics, Department of Neurology A and Neuropsychology, Faculty of Medicine and Pharmacy, Hôpital des Spécialités ONO, University Mohammed V, Rabat, MoroccoLaboratory of Biostatistics, Clinical Research and Epidemiology, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, MoroccoDepartment of Neurosurgery, Faculty of Medicine and Pharmacy, Hôpital Ibn Sina, University Mohammed V, Rabat, MoroccoDepartment of Neuroradiology, Faculty of Medicine and Pharmacy, Hôpital des Spécialités ONO, University Mohammed V, Rabat, MoroccoDepartment of Neurosurgery, Faculty of Medicine and Pharmacy, Hôpital Ibn Sina, University Mohammed V, Rabat, MoroccoDepartment of Neuroradiology, Faculty of Medicine and Pharmacy, Hôpital des Spécialités ONO, University Mohammed V, Rabat, MoroccoResearch Team in Neurology and Neurogenetics, Department of Neurology A and Neuropsychology, Faculty of Medicine and Pharmacy, Hôpital des Spécialités ONO, University Mohammed V, Rabat, MoroccoResearch Team in Neurology and Neurogenetics, Department of Neurology B and Neurogenetics, Faculty of Medicine and Pharmacy, Hôpital des Spécialités ONO, University Mohammed V, Rabat, MoroccoResearch Team in Neurology and Neurogenetics, Department of Neurology A and Neuropsychology, Faculty of Medicine and Pharmacy, Hôpital des Spécialités ONO, University Mohammed V, Rabat, MoroccoResearch Team in Neurology and Neurogenetics, Department of Neurology A and Neuropsychology, Faculty of Medicine and Pharmacy, Hôpital des Spécialités ONO, University Mohammed V, Rabat, MoroccoDepartment of Neuroradiology, Faculty of Medicine and Pharmacy, Hôpital des Spécialités ONO, University Mohammed V, Rabat, MoroccoDepartment of Neurosurgery, Faculty of Medicine and Pharmacy, Hôpital Ibn Sina, University Mohammed V, Rabat, MoroccoDepartment of Anesthesia and Intensive Care, Faculty of Medicine and Pharmacy, Hôpital des Spécialités ONO, University Mohammed V, Rabat, MoroccoDepartment of Anesthesia and Intensive Care, Faculty of Medicine and Pharmacy, Hôpital des Spécialités ONO, University Mohammed V, Rabat, MoroccoDepartment of Surgical Intensive Care, Faculty of Medicine and Pharmacy, Hôpital Ibn Sina, University Mohammed V, Rabat, MoroccoResearch Team in Neurology and Neurogenetics, Department of Neurology A and Neuropsychology, Faculty of Medicine and Pharmacy, Hôpital des Spécialités ONO, University Mohammed V, Rabat, MoroccoResearch Team in Neurology and Neurogenetics, Department of Neurology B and Neurogenetics, Faculty of Medicine and Pharmacy, Hôpital des Spécialités ONO, University Mohammed V, Rabat, MoroccoResearch Team in Neurology and Neurogenetics, Department of Neurology B and Neurogenetics, Faculty of Medicine and Pharmacy, Hôpital des Spécialités ONO, University Mohammed V, Rabat, MoroccoResearch Team in Neurology and Neurogenetics, Department of Neurology B and Neurogenetics, Faculty of Medicine and Pharmacy, Hôpital des Spécialités ONO, University Mohammed V, Rabat, MoroccoResearch Team in Neurology and Neurogenetics, Department of Neurology B and Neurogenetics, Faculty of Medicine and Pharmacy, Hôpital des Spécialités ONO, University Mohammed V, Rabat, MoroccoDepartment of Neurosurgery, Faculty of Medicine and Pharmacy, Centre de Rehabilitation et de Neurosciences, Hôpital des Spécialités ONO, University Mohammed V, Rabat, MoroccoDepartment of Neurosurgery, Faculty of Medicine and Pharmacy, Centre de Rehabilitation et de Neurosciences, Hôpital des Spécialités ONO, University Mohammed V, Rabat, MoroccoDepartment of Neurosurgery, Faculty of Medicine and Pharmacy, Hôpital Ibn Sina, University Mohammed V, Rabat, MoroccoResearch Team in Neurology and Neurogenetics, Department of Neurology B and Neurogenetics, Faculty of Medicine and Pharmacy, Hôpital des Spécialités ONO, University Mohammed V, Rabat, MoroccoDepartment of Neurosurgery, Faculty of Medicine and Pharmacy, Centre de Rehabilitation et de Neurosciences, Hôpital des Spécialités ONO, University Mohammed V, Rabat, MoroccoDepartment of Neurosurgery, Faculty of Medicine and Pharmacy, Centre de Rehabilitation et de Neurosciences, Hôpital des Spécialités ONO, University Mohammed V, Rabat, MoroccoCentre National de la Recherche Scientifique, Institut des Maladies Neurodégénératives, Univ. de Bordeaux UMR 5293, Bordeaux, FranceResearch Team in Neurology and Neurogenetics, Department of Neurology B and Neurogenetics, Faculty of Medicine and Pharmacy, Hôpital des Spécialités ONO, University Mohammed V, Rabat, MoroccoIntroduction: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is known as a therapy of choice of advanced Parkinson's disease. The present study aimed to assess the beneficial and side effects of STN DBS in Moroccan Parkinsonian patients.Material and Methods: Thirty five patients underwent bilateral STN DBS from 2008 to 2016 in the Rabat University Hospital. Patients were assessed preoperatively and followed up for 6 to 12 months using the Unified Parkinson's Disease Rating Scale in four conditions (stimulation OFF and ON and medication OFF and ON), the levodopa-equivalent daily dose (LEDD), dyskinesia and fluctuation scores and PDQ39 scale for quality of life (QOL). Postoperative side effects were also recorded.Results: The mean age at disease onset was 42.31 ± 7.29 years [28–58] and the mean age at surgery was 54.66 ± 8.51 years [34–70]. The median disease duration was 11.95 ± 4.28 years [5–22]. Sixty-three percentage of patients were male. 11.4% of patients were tremor dominant while 45.71 showed akinetic-rigid form and 42.90 were classified as mixed phenotype. The LEDD before surgery was 1200 mg/day [800-1500]. All patients had motor fluctuations whereas non-motor fluctuations were present in 61.80% of cases. STN DBS decreased the LEDD by 51.72%, as the mean LEDD post-surgery was 450 [188-800]. The UPDRS-III was improved by 52.27%, dyskinesia score by 66.70% and motor fluctuations by 50%, whereas QOL improved by 27.12%. Post-operative side effects were hypophonia (2 cases), infection (3 cases), and pneumocephalus (2 cases).Conclusion: Our results showed that STN DBS is an effective treatment in Moroccan Parkinsonian patients leading to a major improvement of the most disabling symptoms (dyskinesia, motor fluctuation) and a better QOL.https://www.frontiersin.org/article/10.3389/fneur.2018.00532/fullParkinson diseasedeep brain stimulationsubthalamic nucleusquality of lifesurgical benefitclinical outcome |