microRNAs, the Link Between Dengue Virus and the Host Genome
Dengue virus (DENV) is a small envelope virus of Flaviviridae that is mainly transmitted by Aedes aegypti and Aedes albopictus. It can cause dengue fever with mild clinical symptoms or even life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). At present, there are no spec...
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doaj-01c4aad6306349d18a61b08984f0a8a02021-08-11T07:40:58ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2021-08-011210.3389/fmicb.2021.714409714409microRNAs, the Link Between Dengue Virus and the Host GenomeYinghua Su0Ting Lin1Chun Liu2Cui Cheng3Xiao Han4Xiwen Jiang5College of Biological Science and Engineering, Fuzhou University, Fujian, ChinaCollege of Biological Science and Engineering, Fuzhou University, Fujian, ChinaCollege of Biological Science and Engineering, Fuzhou University, Fujian, ChinaCollege of Biological Science and Engineering, Fuzhou University, Fujian, ChinaCollege of Biological Science and Engineering, Fuzhou University, Fujian, ChinaDAAN Gene Co., Ltd. of Sun Yat-sen University, Guangdong, ChinaDengue virus (DENV) is a small envelope virus of Flaviviridae that is mainly transmitted by Aedes aegypti and Aedes albopictus. It can cause dengue fever with mild clinical symptoms or even life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). At present, there are no specific drugs or mature vaccine products to treat DENV. microRNAs (miRNAs) are a class of important non-coding small molecular RNAs that regulate gene expression at the post-transcriptional level. It is involved in and regulates a series of important life processes, such as growth and development, cell differentiation, cell apoptosis, anti-virus, and anti-tumor. miRNAs also play important roles in interactions between host and viral genome transcriptomes. Host miRNAs can directly target the genome of the virus or regulate host factors to promote or inhibit virus replication. Understanding the expression and function of miRNAs during infection with DENV and the related signal molecules of the miRNA-mediated regulatory network will provide new insights for the development of miRNA-based therapies.https://www.frontiersin.org/articles/10.3389/fmicb.2021.714409/fullmicroRNAdengue virushost–pathogen interactionvirus replicationsignaling/signaling pathways |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yinghua Su Ting Lin Chun Liu Cui Cheng Xiao Han Xiwen Jiang |
spellingShingle |
Yinghua Su Ting Lin Chun Liu Cui Cheng Xiao Han Xiwen Jiang microRNAs, the Link Between Dengue Virus and the Host Genome Frontiers in Microbiology microRNA dengue virus host–pathogen interaction virus replication signaling/signaling pathways |
author_facet |
Yinghua Su Ting Lin Chun Liu Cui Cheng Xiao Han Xiwen Jiang |
author_sort |
Yinghua Su |
title |
microRNAs, the Link Between Dengue Virus and the Host Genome |
title_short |
microRNAs, the Link Between Dengue Virus and the Host Genome |
title_full |
microRNAs, the Link Between Dengue Virus and the Host Genome |
title_fullStr |
microRNAs, the Link Between Dengue Virus and the Host Genome |
title_full_unstemmed |
microRNAs, the Link Between Dengue Virus and the Host Genome |
title_sort |
micrornas, the link between dengue virus and the host genome |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Microbiology |
issn |
1664-302X |
publishDate |
2021-08-01 |
description |
Dengue virus (DENV) is a small envelope virus of Flaviviridae that is mainly transmitted by Aedes aegypti and Aedes albopictus. It can cause dengue fever with mild clinical symptoms or even life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). At present, there are no specific drugs or mature vaccine products to treat DENV. microRNAs (miRNAs) are a class of important non-coding small molecular RNAs that regulate gene expression at the post-transcriptional level. It is involved in and regulates a series of important life processes, such as growth and development, cell differentiation, cell apoptosis, anti-virus, and anti-tumor. miRNAs also play important roles in interactions between host and viral genome transcriptomes. Host miRNAs can directly target the genome of the virus or regulate host factors to promote or inhibit virus replication. Understanding the expression and function of miRNAs during infection with DENV and the related signal molecules of the miRNA-mediated regulatory network will provide new insights for the development of miRNA-based therapies. |
topic |
microRNA dengue virus host–pathogen interaction virus replication signaling/signaling pathways |
url |
https://www.frontiersin.org/articles/10.3389/fmicb.2021.714409/full |
work_keys_str_mv |
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