Effects of Fermented Mushroom of Cordyceps sinensis, Rich in Selenium, on Uterine Cervix Cancer

Effects of Fermented Mushroom of Cordyceps sinensis, Rich in Selenium, on Uterine Cervix Cancer

The purpose of this study was to investigate the effect of fermented mushroom of Cordyceps sinensis (CS), rich in selenium (Se-CS), on uterine cervical cancer in mice. The methylcholanthrene- (MCA-) induced tumor model was used in this paper. After the mice were administered Se-CS, the animals show...

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Main Authors: Jing Ji, Juan Liu, Haijuan Liu, Yueling Wang
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:Evidence-Based Complementary and Alternative Medicine
Online Access:http://dx.doi.org/10.1155/2014/173180
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spelling doaj-01cbcabbedc24b2889fab2a8469866ae2020-11-24T21:59:01ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882014-01-01201410.1155/2014/173180173180Effects of Fermented Mushroom of Cordyceps sinensis, Rich in Selenium, on Uterine Cervix CancerJing Ji0Juan Liu1Haijuan Liu2Yueling Wang3Department of Gynecology and Obstetrics, First Affiliated Hospital of Medical School, Xi’an Jiaotong University, Xi’an 710061, ChinaDepartment of Obstetrics, Maternal & Child Health Care Hospital of Shanxi Province, Xi’an 710003, ChinaDepartment of Gynecology and Obstetrics, First Affiliated Hospital of Medical School, Xi’an Jiaotong University, Xi’an 710061, ChinaDepartment of Gynecology and Obstetrics, First Affiliated Hospital of Medical School, Xi’an Jiaotong University, Xi’an 710061, ChinaThe purpose of this study was to investigate the effect of fermented mushroom of Cordyceps sinensis (CS), rich in selenium (Se-CS), on uterine cervical cancer in mice. The methylcholanthrene- (MCA-) induced tumor model was used in this paper. After the mice were administered Se-CS, the animals showed 40% tumor incidence (P<0.05). Se-CS also enhanced the immune functions. Se-CS treatment showed significant (P<0.05–0.01) restoration in the level of glutathione content, lipid peroxidation, glutathione peroxidase activity, glutathione reductase activity, catalase activity, Na+/K+-ATPase activity, and glutathione S transferase activity. This finding suggested that the concomitant use of Se and CS could be a potential therapeutic approach to improve the efficacy of therapy for uterine cervical cancer.http://dx.doi.org/10.1155/2014/173180
collection DOAJ
language English
format Article
sources DOAJ
author Jing Ji
Juan Liu
Haijuan Liu
Yueling Wang
spellingShingle Jing Ji
Juan Liu
Haijuan Liu
Yueling Wang
Effects of Fermented Mushroom of Cordyceps sinensis, Rich in Selenium, on Uterine Cervix Cancer
Evidence-Based Complementary and Alternative Medicine
author_facet Jing Ji
Juan Liu
Haijuan Liu
Yueling Wang
author_sort Jing Ji
title Effects of Fermented Mushroom of Cordyceps sinensis, Rich in Selenium, on Uterine Cervix Cancer
title_short Effects of Fermented Mushroom of Cordyceps sinensis, Rich in Selenium, on Uterine Cervix Cancer
title_full Effects of Fermented Mushroom of Cordyceps sinensis, Rich in Selenium, on Uterine Cervix Cancer
title_fullStr Effects of Fermented Mushroom of Cordyceps sinensis, Rich in Selenium, on Uterine Cervix Cancer
title_full_unstemmed Effects of Fermented Mushroom of Cordyceps sinensis, Rich in Selenium, on Uterine Cervix Cancer
title_sort effects of fermented mushroom of cordyceps sinensis, rich in selenium, on uterine cervix cancer
publisher Hindawi Limited
series Evidence-Based Complementary and Alternative Medicine
issn 1741-427X
1741-4288
publishDate 2014-01-01
description The purpose of this study was to investigate the effect of fermented mushroom of Cordyceps sinensis (CS), rich in selenium (Se-CS), on uterine cervical cancer in mice. The methylcholanthrene- (MCA-) induced tumor model was used in this paper. After the mice were administered Se-CS, the animals showed 40% tumor incidence (P<0.05). Se-CS also enhanced the immune functions. Se-CS treatment showed significant (P<0.05–0.01) restoration in the level of glutathione content, lipid peroxidation, glutathione peroxidase activity, glutathione reductase activity, catalase activity, Na+/K+-ATPase activity, and glutathione S transferase activity. This finding suggested that the concomitant use of Se and CS could be a potential therapeutic approach to improve the efficacy of therapy for uterine cervical cancer.
url http://dx.doi.org/10.1155/2014/173180
work_keys_str_mv AT jingji effectsoffermentedmushroomofcordycepssinensisrichinseleniumonuterinecervixcancer
AT juanliu effectsoffermentedmushroomofcordycepssinensisrichinseleniumonuterinecervixcancer
AT haijuanliu effectsoffermentedmushroomofcordycepssinensisrichinseleniumonuterinecervixcancer
AT yuelingwang effectsoffermentedmushroomofcordycepssinensisrichinseleniumonuterinecervixcancer
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