Effect of two days treatment with orlistat on plasma leptin in obese patients without weight loss
Objective: Little is known about the impact of orlistat on the leptin system. We studied the plasma leptin and satiety sensation response for two days of orlistat treatment without hypocaloric diet and weight loss. Material and methods: Twenty obese female subjects were recruited from our medical ou...
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Arán Ediciones, S. L.
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doaj-01d372d2718e4a8b948ee1a1bbe3da4e2020-11-24T21:34:57ZengArán Ediciones, S. L.Nutrición Hospitalaria0212-161133229229710.20960/nh.106S0212-16112016000200017Effect of two days treatment with orlistat on plasma leptin in obese patients without weight lossAna Rodríguez-Valle0María Ángeles Navarro-Ferrando1Diana Boj-Carceller2Jesús Fernando Escanero-Marcén3Alejandro Sanz-Paris4Hospital Universitario Miguel Servet de ZaragozaUniversidad de ZaragozaHospital Universitario Miguel Servet de ZaragozaUniversidad de ZaragozaHospital Universitario Miguel Servet de ZaragozaObjective: Little is known about the impact of orlistat on the leptin system. We studied the plasma leptin and satiety sensation response for two days of orlistat treatment without hypocaloric diet and weight loss. Material and methods: Twenty obese female subjects were recruited from our medical outpatient clinics. All of these subjects had previously received advice on dietary restriction and lifestyle modification, but remained obese with a stable body weight for at least six months before recruitment for the study. Results: Subjects were given 120 mg orlistat 3 times daily and were asked to maintain their usual diet. At baseline and two days after the treatment with orlistat, physical examination, hunger and blood analysis were repeated. There were no significant differences observed regarding energy dietary intake, body weight and waist-hip ratio, or in plasma glucose, insulin c-peptide concentrations. Only plasma leptin and triglycerides concentrations decreased (p: 0.0001 and 0.01 respectively). Decrease in plasma leptin concentration was positively correlated with changes observed in plasma triglycerides concentration (p: 0.01, r2: 0.45). Pre-dinner hunger increased and was negatively correlated with decrease in leptin (p: 0.0001, r2: 0.74) and triglycerides (p: 0.02, r2: 0.59). Conclusion: These data suggest that the partial fat malabsorption induced by the treatment with orlistat quickly reduces plasma triglycerides and leptin. This decrease is associated with increased appetite before intake following the main meal of the day.http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112016000200017&lng=en&tlng=enLeptinaOrlistatTriglicéridosObesidadSociedad |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ana Rodríguez-Valle María Ángeles Navarro-Ferrando Diana Boj-Carceller Jesús Fernando Escanero-Marcén Alejandro Sanz-Paris |
spellingShingle |
Ana Rodríguez-Valle María Ángeles Navarro-Ferrando Diana Boj-Carceller Jesús Fernando Escanero-Marcén Alejandro Sanz-Paris Effect of two days treatment with orlistat on plasma leptin in obese patients without weight loss Nutrición Hospitalaria Leptina Orlistat Triglicéridos Obesidad Sociedad |
author_facet |
Ana Rodríguez-Valle María Ángeles Navarro-Ferrando Diana Boj-Carceller Jesús Fernando Escanero-Marcén Alejandro Sanz-Paris |
author_sort |
Ana Rodríguez-Valle |
title |
Effect of two days treatment with orlistat on plasma leptin in obese patients without weight loss |
title_short |
Effect of two days treatment with orlistat on plasma leptin in obese patients without weight loss |
title_full |
Effect of two days treatment with orlistat on plasma leptin in obese patients without weight loss |
title_fullStr |
Effect of two days treatment with orlistat on plasma leptin in obese patients without weight loss |
title_full_unstemmed |
Effect of two days treatment with orlistat on plasma leptin in obese patients without weight loss |
title_sort |
effect of two days treatment with orlistat on plasma leptin in obese patients without weight loss |
publisher |
Arán Ediciones, S. L. |
series |
Nutrición Hospitalaria |
issn |
0212-1611 |
description |
Objective: Little is known about the impact of orlistat on the leptin system. We studied the plasma leptin and satiety sensation response for two days of orlistat treatment without hypocaloric diet and weight loss. Material and methods: Twenty obese female subjects were recruited from our medical outpatient clinics. All of these subjects had previously received advice on dietary restriction and lifestyle modification, but remained obese with a stable body weight for at least six months before recruitment for the study. Results: Subjects were given 120 mg orlistat 3 times daily and were asked to maintain their usual diet. At baseline and two days after the treatment with orlistat, physical examination, hunger and blood analysis were repeated. There were no significant differences observed regarding energy dietary intake, body weight and waist-hip ratio, or in plasma glucose, insulin c-peptide concentrations. Only plasma leptin and triglycerides concentrations decreased (p: 0.0001 and 0.01 respectively). Decrease in plasma leptin concentration was positively correlated with changes observed in plasma triglycerides concentration (p: 0.01, r2: 0.45). Pre-dinner hunger increased and was negatively correlated with decrease in leptin (p: 0.0001, r2: 0.74) and triglycerides (p: 0.02, r2: 0.59). Conclusion: These data suggest that the partial fat malabsorption induced by the treatment with orlistat quickly reduces plasma triglycerides and leptin. This decrease is associated with increased appetite before intake following the main meal of the day. |
topic |
Leptina Orlistat Triglicéridos Obesidad Sociedad |
url |
http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112016000200017&lng=en&tlng=en |
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