The Value of Screening for Celiac Disease in Systemic Lupus Erythematosus: A Single Experience of a Tertiary Medical Center
Abstract Introduction Systemic lupus erythematosus (SLE) is a multi-organ inflammatory disease associated with autoimmune diseases. The aim of the study is to assessed the frequency of celiac disease (CD) in adults and children with SLE (aSLE and cSLE, respectively) and compare them with rheumatoid...
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doaj-01d70ec1aa3544b799077d530c6cb2e52021-07-25T11:45:41ZengAdis, Springer HealthcareRheumatology and Therapy2198-65762198-65842020-07-017364965610.1007/s40744-020-00223-6The Value of Screening for Celiac Disease in Systemic Lupus Erythematosus: A Single Experience of a Tertiary Medical CenterFahidah AlEnzi0Mada Yateem1Manal Shaikh2Fahad AlSohaibani3Badryah Alhaymouni4AlShaikh Ahmed5Sulaiman M. Al-Mayouf6Clinical Sciences, College of Medicine, Princess Nourah Bint Abdulrahman UniversityPediatric Rheumatology, King Faisal Specialist Hospital and Research CenterPediatric Rheumatology, King Faisal Specialist Hospital and Research CenterAdult Gastroenterology, King Faisal Specialist Hospital and Research CenterAdult Rheumatology, King Faisal Specialist Hospital and Research CenterAdult Rheumatology, King Faisal Specialist Hospital and Research CenterPediatric Rheumatology, King Faisal Specialist Hospital and Research CenterAbstract Introduction Systemic lupus erythematosus (SLE) is a multi-organ inflammatory disease associated with autoimmune diseases. The aim of the study is to assessed the frequency of celiac disease (CD) in adults and children with SLE (aSLE and cSLE, respectively) and compare them with rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) patients; the study also explored the clinical impact of CD serologic markers on SLE disease activity and severity. Methods This was a cross-sectional study. Patients with SLE who had regular follow-up in rheumatology clinics were evaluated for laboratory and clinical variables using serology and the SLE Disease Activity Index (SLEDAI). To assess the occurrence of CD serology in cSLE and aSLE and the clinical impact of CD serologic markers on SLE, patients were tested for antigliadin (AGA), anti-endomysium (EmA) and anti-tissue transglutaminase (tTG) antibodies. RA and JIA patients were included for comparison. Duodenal biopsy was conducted in patients who exhibited CD markers. Results The CD marker was found in 29 (11.6%) of the 250 patients. AGA was present in seven aSLE patients and tTG in two (11.1%). Among cSLE patients, the autoantibody was present in 17.6% (AGA in four, tTG in two, and EmA in three). For RA patients, five had AGA and tTG and one had EmA, with an overall positivity of 9.7%. Five JIA patients had AGA (four with EmA and five with tTG) with overall positivity of 10.9%; the serum IgA level was normal in all patients except one. Duodenal endoscopic biopsy was performed in patients with positive CD markers (two declined). Histologic confirmation of CD was reported in one RA and one JIA patient but in none of the SLE patients. There was no correlation between the presence of CD markers and autoantibodies in SLE. Conclusion CD antibodies did not influence SLE activity. Thus, SLE patients may not need to be screened for CD antibodies.https://doi.org/10.1007/s40744-020-00223-6Celiac diseaseJuvenile idiopathic arthritisRheumatoid arthritisSystemic lupus erythematosus |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fahidah AlEnzi Mada Yateem Manal Shaikh Fahad AlSohaibani Badryah Alhaymouni AlShaikh Ahmed Sulaiman M. Al-Mayouf |
spellingShingle |
Fahidah AlEnzi Mada Yateem Manal Shaikh Fahad AlSohaibani Badryah Alhaymouni AlShaikh Ahmed Sulaiman M. Al-Mayouf The Value of Screening for Celiac Disease in Systemic Lupus Erythematosus: A Single Experience of a Tertiary Medical Center Rheumatology and Therapy Celiac disease Juvenile idiopathic arthritis Rheumatoid arthritis Systemic lupus erythematosus |
author_facet |
Fahidah AlEnzi Mada Yateem Manal Shaikh Fahad AlSohaibani Badryah Alhaymouni AlShaikh Ahmed Sulaiman M. Al-Mayouf |
author_sort |
Fahidah AlEnzi |
title |
The Value of Screening for Celiac Disease in Systemic Lupus Erythematosus: A Single Experience of a Tertiary Medical Center |
title_short |
The Value of Screening for Celiac Disease in Systemic Lupus Erythematosus: A Single Experience of a Tertiary Medical Center |
title_full |
The Value of Screening for Celiac Disease in Systemic Lupus Erythematosus: A Single Experience of a Tertiary Medical Center |
title_fullStr |
The Value of Screening for Celiac Disease in Systemic Lupus Erythematosus: A Single Experience of a Tertiary Medical Center |
title_full_unstemmed |
The Value of Screening for Celiac Disease in Systemic Lupus Erythematosus: A Single Experience of a Tertiary Medical Center |
title_sort |
value of screening for celiac disease in systemic lupus erythematosus: a single experience of a tertiary medical center |
publisher |
Adis, Springer Healthcare |
series |
Rheumatology and Therapy |
issn |
2198-6576 2198-6584 |
publishDate |
2020-07-01 |
description |
Abstract Introduction Systemic lupus erythematosus (SLE) is a multi-organ inflammatory disease associated with autoimmune diseases. The aim of the study is to assessed the frequency of celiac disease (CD) in adults and children with SLE (aSLE and cSLE, respectively) and compare them with rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) patients; the study also explored the clinical impact of CD serologic markers on SLE disease activity and severity. Methods This was a cross-sectional study. Patients with SLE who had regular follow-up in rheumatology clinics were evaluated for laboratory and clinical variables using serology and the SLE Disease Activity Index (SLEDAI). To assess the occurrence of CD serology in cSLE and aSLE and the clinical impact of CD serologic markers on SLE, patients were tested for antigliadin (AGA), anti-endomysium (EmA) and anti-tissue transglutaminase (tTG) antibodies. RA and JIA patients were included for comparison. Duodenal biopsy was conducted in patients who exhibited CD markers. Results The CD marker was found in 29 (11.6%) of the 250 patients. AGA was present in seven aSLE patients and tTG in two (11.1%). Among cSLE patients, the autoantibody was present in 17.6% (AGA in four, tTG in two, and EmA in three). For RA patients, five had AGA and tTG and one had EmA, with an overall positivity of 9.7%. Five JIA patients had AGA (four with EmA and five with tTG) with overall positivity of 10.9%; the serum IgA level was normal in all patients except one. Duodenal endoscopic biopsy was performed in patients with positive CD markers (two declined). Histologic confirmation of CD was reported in one RA and one JIA patient but in none of the SLE patients. There was no correlation between the presence of CD markers and autoantibodies in SLE. Conclusion CD antibodies did not influence SLE activity. Thus, SLE patients may not need to be screened for CD antibodies. |
topic |
Celiac disease Juvenile idiopathic arthritis Rheumatoid arthritis Systemic lupus erythematosus |
url |
https://doi.org/10.1007/s40744-020-00223-6 |
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