Myeloid leukemias and virally induced lymphomas in miniature inbred swine; development of a large animal tumor model
The lack of a large animal transplantable tumor model has limited the study of novel therapeutic strategies for the treatment of liquid cancers. Swine as a species provide a natural option based on their similarities with humans and their already extensive use in biomedical research. Specifically, t...
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Frontiers Media S.A.
2015-11-01
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Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00332/full |
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doaj-01e7b6cd0ace4d599a3a253601c75ac12020-11-25T01:43:17ZengFrontiers Media S.A.Frontiers in Genetics1664-80212015-11-01610.3389/fgene.2015.00332166444Myeloid leukemias and virally induced lymphomas in miniature inbred swine; development of a large animal tumor modelRAIMON eDURAN-STRUUCK0Abraham eMatar1Christene A. Huang2University of PennsylvaniaUniversity of Central Florida School of MedicineCenter of Transplantation SciencesThe lack of a large animal transplantable tumor model has limited the study of novel therapeutic strategies for the treatment of liquid cancers. Swine as a species provide a natural option based on their similarities with humans and their already extensive use in biomedical research. Specifically, the MGH miniature swine herd retains unique genetic characteristics that facilitate the study of hematopoietic cell and solid organ transplantation. Spontaneously arising liquid cancers in these swine, specifically myeloid leukemias and B cell lymphomas, closely resemble human malignancies. The ability to establish aggressive tumor cell lines in vitro from these naturally occurring malignancies makes a transplantable tumor model a close reality. Here, we discuss our experience with myeloid and lymphoid tumors in MHC characterized miniature swine and future approaches regarding the development of a large animal transplantable tumor model.http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00332/fullSwineTransplantation ImmunologyCancerModelCMLPTLD |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
RAIMON eDURAN-STRUUCK Abraham eMatar Christene A. Huang |
spellingShingle |
RAIMON eDURAN-STRUUCK Abraham eMatar Christene A. Huang Myeloid leukemias and virally induced lymphomas in miniature inbred swine; development of a large animal tumor model Frontiers in Genetics Swine Transplantation Immunology Cancer Model CML PTLD |
author_facet |
RAIMON eDURAN-STRUUCK Abraham eMatar Christene A. Huang |
author_sort |
RAIMON eDURAN-STRUUCK |
title |
Myeloid leukemias and virally induced lymphomas in miniature inbred swine; development of a large animal tumor model |
title_short |
Myeloid leukemias and virally induced lymphomas in miniature inbred swine; development of a large animal tumor model |
title_full |
Myeloid leukemias and virally induced lymphomas in miniature inbred swine; development of a large animal tumor model |
title_fullStr |
Myeloid leukemias and virally induced lymphomas in miniature inbred swine; development of a large animal tumor model |
title_full_unstemmed |
Myeloid leukemias and virally induced lymphomas in miniature inbred swine; development of a large animal tumor model |
title_sort |
myeloid leukemias and virally induced lymphomas in miniature inbred swine; development of a large animal tumor model |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Genetics |
issn |
1664-8021 |
publishDate |
2015-11-01 |
description |
The lack of a large animal transplantable tumor model has limited the study of novel therapeutic strategies for the treatment of liquid cancers. Swine as a species provide a natural option based on their similarities with humans and their already extensive use in biomedical research. Specifically, the MGH miniature swine herd retains unique genetic characteristics that facilitate the study of hematopoietic cell and solid organ transplantation. Spontaneously arising liquid cancers in these swine, specifically myeloid leukemias and B cell lymphomas, closely resemble human malignancies. The ability to establish aggressive tumor cell lines in vitro from these naturally occurring malignancies makes a transplantable tumor model a close reality. Here, we discuss our experience with myeloid and lymphoid tumors in MHC characterized miniature swine and future approaches regarding the development of a large animal transplantable tumor model. |
topic |
Swine Transplantation Immunology Cancer Model CML PTLD |
url |
http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00332/full |
work_keys_str_mv |
AT raimoneduranstruuck myeloidleukemiasandvirallyinducedlymphomasinminiatureinbredswinedevelopmentofalargeanimaltumormodel AT abrahamematar myeloidleukemiasandvirallyinducedlymphomasinminiatureinbredswinedevelopmentofalargeanimaltumormodel AT christeneahuang myeloidleukemiasandvirallyinducedlymphomasinminiatureinbredswinedevelopmentofalargeanimaltumormodel |
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