Early Contralateral Shoulder-Arm Morbidity in Breast Cancer Patients Enrolled in a Randomized Trial of Post-Surgery Radiation Therapy
Introduction Shoulder/arm morbidity is a common complication of breast cancer surgery and radiotherapy (RT), but little is known about acute contralateral morbidity. Methods Patients were 118 women enrolled in a RT trial. Arm volume and shoulder mobility were assessed before and 1–3 months after RT....
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doaj-01eaa931da924059958c28ca4c926ed52020-11-25T03:46:27ZengSAGE PublishingBreast Cancer: Basic and Clinical Research1178-22342012-01-01610.4137/BCBCR.S9362Early Contralateral Shoulder-Arm Morbidity in Breast Cancer Patients Enrolled in a Randomized Trial of Post-Surgery Radiation TherapyNele Adriaenssens0Vincent Vinh-hung1Geertje Miedema2Harijati Versmessen3Jan Lamote4Marian Vanhoeij5Pierre Lievens6Hilde Van Parijs7Guy Storme8Mia Voordeckers9Mark De Ridder10Physical Therapy Department, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.Oncology Centre, Department of Radiation therapy, UZ Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.Oncology Centre, Department of Radiation therapy, UZ Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.Oncology Centre, Department of Radiation therapy, UZ Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.Breast Clinic, Oncological Surgery, UZ Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.Breast Clinic, Oncological Surgery, UZ Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.Physical Therapy Department, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.Oncology Centre, Department of Radiation therapy, UZ Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.Oncology Centre, Department of Radiation therapy, UZ Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.Oncology Centre, Department of Radiation therapy, UZ Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.Oncology Centre, Department of Radiation therapy, UZ Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.Introduction Shoulder/arm morbidity is a common complication of breast cancer surgery and radiotherapy (RT), but little is known about acute contralateral morbidity. Methods Patients were 118 women enrolled in a RT trial. Arm volume and shoulder mobility were assessed before and 1–3 months after RT. Correlations and linear regression were used to analyze changes affecting ipsilateral and contralateral arms, and changes affecting relative interlimb differences (RID). Results Changes affecting one limb correlated with changes affecting the other limb. Arm volume between the two limbs correlated (R = 0.57). Risk factors were weight increase and axillary dissection. Contralateral and ipsilateral loss of abduction strongly correlated (R = 0.78). Changes of combined RID exceeding 10% affected the ipsilateral limb in 25% of patients, and the contralateral limb in 18%. Aromatase inhibitor therapy was significantly associated with contralateral loss of abduction. Conclusions High incidence of early contralateral arm morbidity warrants further investigations.https://doi.org/10.4137/BCBCR.S9362 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nele Adriaenssens Vincent Vinh-hung Geertje Miedema Harijati Versmessen Jan Lamote Marian Vanhoeij Pierre Lievens Hilde Van Parijs Guy Storme Mia Voordeckers Mark De Ridder |
spellingShingle |
Nele Adriaenssens Vincent Vinh-hung Geertje Miedema Harijati Versmessen Jan Lamote Marian Vanhoeij Pierre Lievens Hilde Van Parijs Guy Storme Mia Voordeckers Mark De Ridder Early Contralateral Shoulder-Arm Morbidity in Breast Cancer Patients Enrolled in a Randomized Trial of Post-Surgery Radiation Therapy Breast Cancer: Basic and Clinical Research |
author_facet |
Nele Adriaenssens Vincent Vinh-hung Geertje Miedema Harijati Versmessen Jan Lamote Marian Vanhoeij Pierre Lievens Hilde Van Parijs Guy Storme Mia Voordeckers Mark De Ridder |
author_sort |
Nele Adriaenssens |
title |
Early Contralateral Shoulder-Arm Morbidity in Breast Cancer Patients Enrolled in a Randomized Trial of Post-Surgery Radiation Therapy |
title_short |
Early Contralateral Shoulder-Arm Morbidity in Breast Cancer Patients Enrolled in a Randomized Trial of Post-Surgery Radiation Therapy |
title_full |
Early Contralateral Shoulder-Arm Morbidity in Breast Cancer Patients Enrolled in a Randomized Trial of Post-Surgery Radiation Therapy |
title_fullStr |
Early Contralateral Shoulder-Arm Morbidity in Breast Cancer Patients Enrolled in a Randomized Trial of Post-Surgery Radiation Therapy |
title_full_unstemmed |
Early Contralateral Shoulder-Arm Morbidity in Breast Cancer Patients Enrolled in a Randomized Trial of Post-Surgery Radiation Therapy |
title_sort |
early contralateral shoulder-arm morbidity in breast cancer patients enrolled in a randomized trial of post-surgery radiation therapy |
publisher |
SAGE Publishing |
series |
Breast Cancer: Basic and Clinical Research |
issn |
1178-2234 |
publishDate |
2012-01-01 |
description |
Introduction Shoulder/arm morbidity is a common complication of breast cancer surgery and radiotherapy (RT), but little is known about acute contralateral morbidity. Methods Patients were 118 women enrolled in a RT trial. Arm volume and shoulder mobility were assessed before and 1–3 months after RT. Correlations and linear regression were used to analyze changes affecting ipsilateral and contralateral arms, and changes affecting relative interlimb differences (RID). Results Changes affecting one limb correlated with changes affecting the other limb. Arm volume between the two limbs correlated (R = 0.57). Risk factors were weight increase and axillary dissection. Contralateral and ipsilateral loss of abduction strongly correlated (R = 0.78). Changes of combined RID exceeding 10% affected the ipsilateral limb in 25% of patients, and the contralateral limb in 18%. Aromatase inhibitor therapy was significantly associated with contralateral loss of abduction. Conclusions High incidence of early contralateral arm morbidity warrants further investigations. |
url |
https://doi.org/10.4137/BCBCR.S9362 |
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