Job strain and cardiovascular disease risk factors: meta-analysis of individual-participant data from 47,000 men and women.
Job strain is associated with an increased coronary heart disease risk, but few large-scale studies have examined the relationship of this psychosocial characteristic with the biological risk factors that potentially mediate the job strain - heart disease association.We pooled cross-sectional, indiv...
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doaj-01f09ef0e3ee44a0b042e2087995918e2020-11-25T01:49:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0186e6732310.1371/journal.pone.0067323Job strain and cardiovascular disease risk factors: meta-analysis of individual-participant data from 47,000 men and women.Solja T NybergEleonor I FranssonKatriina HeikkiläLars AlfredssonAnnalisa CasiniEls ClaysDirk De BacquerNico DraganoRaimund ErbelJane E FerrieMark HamerKarl-Heinz JöckelFrance KittelAnders KnutssonKarl-Heinz LadwigThorsten LunauMichael G MarmotMaria NordinReiner RuguliesJohannes SiegristAndrew SteptoePeter J M WesterholmHugo WesterlundTöres TheorellEric J BrunnerArchana Singh-ManouxG David BattyMika KivimäkiIPD-Work ConsortiumJob strain is associated with an increased coronary heart disease risk, but few large-scale studies have examined the relationship of this psychosocial characteristic with the biological risk factors that potentially mediate the job strain - heart disease association.We pooled cross-sectional, individual-level data from eight studies comprising 47,045 participants to investigate the association between job strain and the following cardiovascular disease risk factors: diabetes, blood pressure, pulse pressure, lipid fractions, smoking, alcohol consumption, physical inactivity, obesity, and overall cardiovascular disease risk as indexed by the Framingham Risk Score. In age-, sex-, and socioeconomic status-adjusted analyses, compared to those without job strain, people with job strain were more likely to have diabetes (odds ratio 1.29; 95% CI: 1.11-1.51), to smoke (1.14; 1.08-1.20), to be physically inactive (1.34; 1.26-1.41), and to be obese (1.12; 1.04-1.20). The association between job strain and elevated Framingham risk score (1.13; 1.03-1.25) was attributable to the higher prevalence of diabetes, smoking and physical inactivity among those reporting job strain.In this meta-analysis of work-related stress and cardiovascular disease risk factors, job strain was linked to adverse lifestyle and diabetes. No association was observed between job strain, clinic blood pressure or blood lipids.http://europepmc.org/articles/PMC3688665?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Solja T Nyberg Eleonor I Fransson Katriina Heikkilä Lars Alfredsson Annalisa Casini Els Clays Dirk De Bacquer Nico Dragano Raimund Erbel Jane E Ferrie Mark Hamer Karl-Heinz Jöckel France Kittel Anders Knutsson Karl-Heinz Ladwig Thorsten Lunau Michael G Marmot Maria Nordin Reiner Rugulies Johannes Siegrist Andrew Steptoe Peter J M Westerholm Hugo Westerlund Töres Theorell Eric J Brunner Archana Singh-Manoux G David Batty Mika Kivimäki IPD-Work Consortium |
spellingShingle |
Solja T Nyberg Eleonor I Fransson Katriina Heikkilä Lars Alfredsson Annalisa Casini Els Clays Dirk De Bacquer Nico Dragano Raimund Erbel Jane E Ferrie Mark Hamer Karl-Heinz Jöckel France Kittel Anders Knutsson Karl-Heinz Ladwig Thorsten Lunau Michael G Marmot Maria Nordin Reiner Rugulies Johannes Siegrist Andrew Steptoe Peter J M Westerholm Hugo Westerlund Töres Theorell Eric J Brunner Archana Singh-Manoux G David Batty Mika Kivimäki IPD-Work Consortium Job strain and cardiovascular disease risk factors: meta-analysis of individual-participant data from 47,000 men and women. PLoS ONE |
author_facet |
Solja T Nyberg Eleonor I Fransson Katriina Heikkilä Lars Alfredsson Annalisa Casini Els Clays Dirk De Bacquer Nico Dragano Raimund Erbel Jane E Ferrie Mark Hamer Karl-Heinz Jöckel France Kittel Anders Knutsson Karl-Heinz Ladwig Thorsten Lunau Michael G Marmot Maria Nordin Reiner Rugulies Johannes Siegrist Andrew Steptoe Peter J M Westerholm Hugo Westerlund Töres Theorell Eric J Brunner Archana Singh-Manoux G David Batty Mika Kivimäki IPD-Work Consortium |
author_sort |
Solja T Nyberg |
title |
Job strain and cardiovascular disease risk factors: meta-analysis of individual-participant data from 47,000 men and women. |
title_short |
Job strain and cardiovascular disease risk factors: meta-analysis of individual-participant data from 47,000 men and women. |
title_full |
Job strain and cardiovascular disease risk factors: meta-analysis of individual-participant data from 47,000 men and women. |
title_fullStr |
Job strain and cardiovascular disease risk factors: meta-analysis of individual-participant data from 47,000 men and women. |
title_full_unstemmed |
Job strain and cardiovascular disease risk factors: meta-analysis of individual-participant data from 47,000 men and women. |
title_sort |
job strain and cardiovascular disease risk factors: meta-analysis of individual-participant data from 47,000 men and women. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2013-01-01 |
description |
Job strain is associated with an increased coronary heart disease risk, but few large-scale studies have examined the relationship of this psychosocial characteristic with the biological risk factors that potentially mediate the job strain - heart disease association.We pooled cross-sectional, individual-level data from eight studies comprising 47,045 participants to investigate the association between job strain and the following cardiovascular disease risk factors: diabetes, blood pressure, pulse pressure, lipid fractions, smoking, alcohol consumption, physical inactivity, obesity, and overall cardiovascular disease risk as indexed by the Framingham Risk Score. In age-, sex-, and socioeconomic status-adjusted analyses, compared to those without job strain, people with job strain were more likely to have diabetes (odds ratio 1.29; 95% CI: 1.11-1.51), to smoke (1.14; 1.08-1.20), to be physically inactive (1.34; 1.26-1.41), and to be obese (1.12; 1.04-1.20). The association between job strain and elevated Framingham risk score (1.13; 1.03-1.25) was attributable to the higher prevalence of diabetes, smoking and physical inactivity among those reporting job strain.In this meta-analysis of work-related stress and cardiovascular disease risk factors, job strain was linked to adverse lifestyle and diabetes. No association was observed between job strain, clinic blood pressure or blood lipids. |
url |
http://europepmc.org/articles/PMC3688665?pdf=render |
work_keys_str_mv |
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