IL-13 -1112 polymorphism and periodontitis susceptibility: a meta-analysis
Abstract Background Several studies have examined the association between the IL-13 -1112C/T polymorphism and the risk of periodontitis. However, these studies have reached different conclusions. The aim of the current study was to investigate the link between this IL-13 -1112 polymorphism and susce...
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doaj-01f84e46f6ba46508b317b2611c39f652020-11-24T21:40:44ZengBMCBMC Oral Health1472-68312018-02-011811910.1186/s12903-018-0481-yIL-13 -1112 polymorphism and periodontitis susceptibility: a meta-analysisWenbo Zhang0Pu Xu1Zhuogeng Chen2Yanan Cheng3Xiaoni Li4Qiuhua Mao5Department of Oral Implantation, Affiliated Haikou Hospital,Xiangya Medical School, Central South University, Hainan Provincial Stomatology CentreDepartment of Oral Implantation, Affiliated Haikou Hospital,Xiangya Medical School, Central South University, Hainan Provincial Stomatology CentreDepartment of Oral Implantation, Affiliated Haikou Hospital,Xiangya Medical School, Central South University, Hainan Provincial Stomatology CentreDepartment of Oral Implantation, Affiliated Haikou Hospital,Xiangya Medical School, Central South University, Hainan Provincial Stomatology CentreDepartment of Oral Implantation, Affiliated Haikou Hospital,Xiangya Medical School, Central South University, Hainan Provincial Stomatology CentreDepartment of Oral Implantation, Affiliated Haikou Hospital,Xiangya Medical School, Central South University, Hainan Provincial Stomatology CentreAbstract Background Several studies have examined the association between the IL-13 -1112C/T polymorphism and the risk of periodontitis. However, these studies have reached different conclusions. The aim of the current study was to investigate the link between this IL-13 -1112 polymorphism and susceptibility to periodontitis. Methods We utilized electronic databases, including the CNKI (China National Knowledge Infrastructure), Wanfang, PubMed, Embase, and Cochrane Library databases, to manually search for relevant research published through November 30, 2016. The Chinese and English terms used to search the literature included “periodontitis”, “periodontal disease”, “IL 13”, “IL-13”, and “interleukin-13”. In accordance with our inclusion criteria, we selected studies that involved case-control trials. All of these case-control trials described their objectives, design and specific statistical methods. For all included studies, odds ratios (ORs) and 95% confidence intervals (95% CIs) were provided or could be calculated from the study data. The quality of the included literature was evaluated using the Newcastle-Ottawa scale (NOS). STATA 12.0 was used to calculate the sizes of the combined effects and conduct a sensitivity analysis of the results. Results Our meta-analysis included 4 articles representing 5 case-control studies with a total of 710 cases and 671 control subjects. The meta-analysis results indicated that the CC vs TT model, CT vs TT model and TT vs CT + CC model (CC VS TT: OR = 0.615, 95% CI = 0.395–0.957; CT vs TT: OR = 0.518, 95% CI = 0.323–0.830; and TT vs CT + CC: OR = 1.739, 95% CI = 1.130–2.676) were significant in five IL-13 -1112 gene polymorphism and periodontitis susceptibility models. Subgroup analysis indicated that the CC vs TT, CT vs TT and TT vs CT + CC models were significant in the chronic periodontitis (CP) group, whereas no significant differences were found in the five aggressive periodontitis (AgP) group models. The sensitivity analysis showed that dropping any single study did not affect the pooled analysis results. Conclusion The IL-13 -1112 polymorphism may be associated with susceptibility to periodontitis. The IL-13 -1112 gene polymorphism may be associated with susceptibility to CP but not to AgP. Thus, large-scale, multi-ethnic case-control trials are still warranted.http://link.springer.com/article/10.1186/s12903-018-0481-yPeriodontitisGene polymorphismInterleukin-13Meta-analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wenbo Zhang Pu Xu Zhuogeng Chen Yanan Cheng Xiaoni Li Qiuhua Mao |
spellingShingle |
Wenbo Zhang Pu Xu Zhuogeng Chen Yanan Cheng Xiaoni Li Qiuhua Mao IL-13 -1112 polymorphism and periodontitis susceptibility: a meta-analysis BMC Oral Health Periodontitis Gene polymorphism Interleukin-13 Meta-analysis |
author_facet |
Wenbo Zhang Pu Xu Zhuogeng Chen Yanan Cheng Xiaoni Li Qiuhua Mao |
author_sort |
Wenbo Zhang |
title |
IL-13 -1112 polymorphism and periodontitis susceptibility: a meta-analysis |
title_short |
IL-13 -1112 polymorphism and periodontitis susceptibility: a meta-analysis |
title_full |
IL-13 -1112 polymorphism and periodontitis susceptibility: a meta-analysis |
title_fullStr |
IL-13 -1112 polymorphism and periodontitis susceptibility: a meta-analysis |
title_full_unstemmed |
IL-13 -1112 polymorphism and periodontitis susceptibility: a meta-analysis |
title_sort |
il-13 -1112 polymorphism and periodontitis susceptibility: a meta-analysis |
publisher |
BMC |
series |
BMC Oral Health |
issn |
1472-6831 |
publishDate |
2018-02-01 |
description |
Abstract Background Several studies have examined the association between the IL-13 -1112C/T polymorphism and the risk of periodontitis. However, these studies have reached different conclusions. The aim of the current study was to investigate the link between this IL-13 -1112 polymorphism and susceptibility to periodontitis. Methods We utilized electronic databases, including the CNKI (China National Knowledge Infrastructure), Wanfang, PubMed, Embase, and Cochrane Library databases, to manually search for relevant research published through November 30, 2016. The Chinese and English terms used to search the literature included “periodontitis”, “periodontal disease”, “IL 13”, “IL-13”, and “interleukin-13”. In accordance with our inclusion criteria, we selected studies that involved case-control trials. All of these case-control trials described their objectives, design and specific statistical methods. For all included studies, odds ratios (ORs) and 95% confidence intervals (95% CIs) were provided or could be calculated from the study data. The quality of the included literature was evaluated using the Newcastle-Ottawa scale (NOS). STATA 12.0 was used to calculate the sizes of the combined effects and conduct a sensitivity analysis of the results. Results Our meta-analysis included 4 articles representing 5 case-control studies with a total of 710 cases and 671 control subjects. The meta-analysis results indicated that the CC vs TT model, CT vs TT model and TT vs CT + CC model (CC VS TT: OR = 0.615, 95% CI = 0.395–0.957; CT vs TT: OR = 0.518, 95% CI = 0.323–0.830; and TT vs CT + CC: OR = 1.739, 95% CI = 1.130–2.676) were significant in five IL-13 -1112 gene polymorphism and periodontitis susceptibility models. Subgroup analysis indicated that the CC vs TT, CT vs TT and TT vs CT + CC models were significant in the chronic periodontitis (CP) group, whereas no significant differences were found in the five aggressive periodontitis (AgP) group models. The sensitivity analysis showed that dropping any single study did not affect the pooled analysis results. Conclusion The IL-13 -1112 polymorphism may be associated with susceptibility to periodontitis. The IL-13 -1112 gene polymorphism may be associated with susceptibility to CP but not to AgP. Thus, large-scale, multi-ethnic case-control trials are still warranted. |
topic |
Periodontitis Gene polymorphism Interleukin-13 Meta-analysis |
url |
http://link.springer.com/article/10.1186/s12903-018-0481-y |
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