Physical Interaction between HPV16E7 and the Actin-Binding Protein Gelsolin Regulates Epithelial-Mesenchymal Transition via HIPPO-YAP Axis

Physical Interaction between HPV16E7 and the Actin-Binding Protein Gelsolin Regulates Epithelial-Mesenchymal Transition via HIPPO-YAP Axis

Human papillomavirus 16 (HPV16) exhibits a strong oncogenic potential mainly in cervical, anogenital and oropharyngeal cancers. The E6 and E7 viral oncoproteins, acting via specific interactions with host cellular targets, are required for cell transformation and maintenance of the transformed pheno...

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Bibliographic Details
Main Authors: Paola Matarrese, Rosa Vona, Barbara Ascione, Marco G. Paggi, Anna Maria Mileo
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
HPV16E7
EMT
HIPPO-YAP pathway
Gelsolin
actin cytoskeleton
RhoGTPases
Online Access:https://www.mdpi.com/2072-6694/13/2/353

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