Comparison of a Novel Bisphosphonate Prodrug and Zoledronic Acid in the Induction of Cytotoxicity in Human Vγ2Vδ2 T Cells
Increasing attention has been paid to human γδ T cells expressing Vγ2Vδ2 T cell receptor (also termed Vγ9Vδ2) in the field of cancer immunotherapy. We have previously demonstrated that a novel bisphosphonate prodrug, tetrakis-pivaloyloxymethyl 2-(thiazole-2-ylamino)ethylidene-1,1-bisphosphonate (PTA...
Main Authors: | Daisuke Okuno, Yuki Sugiura, Noriho Sakamoto, Mohammed S. O. Tagod, Masashi Iwasaki, Shuto Noda, Akihiro Tamura, Hiroaki Senju, Yasuhiro Umeyama, Hiroyuki Yamaguchi, Makoto Suematsu, Craig T. Morita, Yoshimasa Tanaka, Hiroshi Mukae |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-07-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.01405/full |
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