Initial Experience of Challenge-Free MRI-Based Oxygen Extraction Fraction Mapping of Ischemic Stroke at Various Stages: Comparison With Perfusion and Diffusion Mapping
MRI-based oxygen extraction fraction imaging has a great potential benefit in the selection of clinical strategies for ischemic stroke patients. This study aimed to evaluate the performance of a challenge-free oxygen extraction fraction (OEF) mapping in a cohort of acute and subacute ischemic stroke...
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doaj-021c7a61a90a4293a3a7fc7eb74c6a8e2020-11-25T03:28:24ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2020-09-011410.3389/fnins.2020.535441535441Initial Experience of Challenge-Free MRI-Based Oxygen Extraction Fraction Mapping of Ischemic Stroke at Various Stages: Comparison With Perfusion and Diffusion MappingShun Zhang0Junghun Cho1Junghun Cho2Thanh D. Nguyen3Pascal Spincemaille4Ajay Gupta5Wenzhen Zhu6Yi Wang7Yi Wang8Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Radiology, Weill Cornell Medicine, New York, NY, United StatesDepartment of Biomedical Engineering, Cornell University, Ithaca, NY, United StatesDepartment of Radiology, Weill Cornell Medicine, New York, NY, United StatesDepartment of Radiology, Weill Cornell Medicine, New York, NY, United StatesDepartment of Radiology, Weill Cornell Medicine, New York, NY, United StatesDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Radiology, Weill Cornell Medicine, New York, NY, United StatesDepartment of Biomedical Engineering, Cornell University, Ithaca, NY, United StatesMRI-based oxygen extraction fraction imaging has a great potential benefit in the selection of clinical strategies for ischemic stroke patients. This study aimed to evaluate the performance of a challenge-free oxygen extraction fraction (OEF) mapping in a cohort of acute and subacute ischemic stroke patients. Consecutive ischemic stroke patients (a total of 30 with 5 in the acute stage, 19 in the early subacute stage, and 6 in the late subacute stage) were recruited. All subjects underwent MRI including multi-echo gradient echo (mGRE), diffusion weighted imaging (DWI), and 3D-arterial spin labeling (ASL). OEF maps were generated from mGRE phase + magnitude data, which were processed using quantitative susceptibility mapping (QSM) + quantitative blood oxygen level-dependent (qBOLD) imaging with cluster analysis of time evolution. Cerebral blood flow (CBF) and apparent diffusion coefficient (ADC) maps were reconstructed from 3D-ASL and DWI, respectively. Further, cerebral metabolic rate of oxygen (CMRO2) was calculated as the product of CBF and OEF. OEF, CMRO2, CBF, and ADC values in the ischemic cores (absolute values) and their contrasts to the contralateral regions (relative values) were evaluated. One-way analysis of variance (ANOVA) was used to compare OEF, CMRO2, CBF, and ADC values and their relative values among different stroke stages. The OEF value of infarct core showed a trend of decrease from acute, to early subacute, and to late subacute stages of ischemic stroke. Significant differences among the three stroke stages were only observed in the absolute OEF (F = 6.046, p = 0.005) and relative OEF (F = 5.699, p = 0.009) values of the ischemic core, but not in other measurements (absolute and relative CMRO2, CBF, ADC values, all values of p > 0.05). In conclusion, the challenge-free QSM + qBOLD-generated OEF mapping can be performed on stroke patients. It can provide more information on tissue viability that was not available with CBF and ADC and, thus, may help to better manage ischemic stroke patients.https://www.frontiersin.org/article/10.3389/fnins.2020.535441/fullischemic strokeMRIoxygen extraction fractioncerebral metabolic rate of oxygenquantitative susceptibility mappingcerebral blood flow |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shun Zhang Junghun Cho Junghun Cho Thanh D. Nguyen Pascal Spincemaille Ajay Gupta Wenzhen Zhu Yi Wang Yi Wang |
spellingShingle |
Shun Zhang Junghun Cho Junghun Cho Thanh D. Nguyen Pascal Spincemaille Ajay Gupta Wenzhen Zhu Yi Wang Yi Wang Initial Experience of Challenge-Free MRI-Based Oxygen Extraction Fraction Mapping of Ischemic Stroke at Various Stages: Comparison With Perfusion and Diffusion Mapping Frontiers in Neuroscience ischemic stroke MRI oxygen extraction fraction cerebral metabolic rate of oxygen quantitative susceptibility mapping cerebral blood flow |
author_facet |
Shun Zhang Junghun Cho Junghun Cho Thanh D. Nguyen Pascal Spincemaille Ajay Gupta Wenzhen Zhu Yi Wang Yi Wang |
author_sort |
Shun Zhang |
title |
Initial Experience of Challenge-Free MRI-Based Oxygen Extraction Fraction Mapping of Ischemic Stroke at Various Stages: Comparison With Perfusion and Diffusion Mapping |
title_short |
Initial Experience of Challenge-Free MRI-Based Oxygen Extraction Fraction Mapping of Ischemic Stroke at Various Stages: Comparison With Perfusion and Diffusion Mapping |
title_full |
Initial Experience of Challenge-Free MRI-Based Oxygen Extraction Fraction Mapping of Ischemic Stroke at Various Stages: Comparison With Perfusion and Diffusion Mapping |
title_fullStr |
Initial Experience of Challenge-Free MRI-Based Oxygen Extraction Fraction Mapping of Ischemic Stroke at Various Stages: Comparison With Perfusion and Diffusion Mapping |
title_full_unstemmed |
Initial Experience of Challenge-Free MRI-Based Oxygen Extraction Fraction Mapping of Ischemic Stroke at Various Stages: Comparison With Perfusion and Diffusion Mapping |
title_sort |
initial experience of challenge-free mri-based oxygen extraction fraction mapping of ischemic stroke at various stages: comparison with perfusion and diffusion mapping |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroscience |
issn |
1662-453X |
publishDate |
2020-09-01 |
description |
MRI-based oxygen extraction fraction imaging has a great potential benefit in the selection of clinical strategies for ischemic stroke patients. This study aimed to evaluate the performance of a challenge-free oxygen extraction fraction (OEF) mapping in a cohort of acute and subacute ischemic stroke patients. Consecutive ischemic stroke patients (a total of 30 with 5 in the acute stage, 19 in the early subacute stage, and 6 in the late subacute stage) were recruited. All subjects underwent MRI including multi-echo gradient echo (mGRE), diffusion weighted imaging (DWI), and 3D-arterial spin labeling (ASL). OEF maps were generated from mGRE phase + magnitude data, which were processed using quantitative susceptibility mapping (QSM) + quantitative blood oxygen level-dependent (qBOLD) imaging with cluster analysis of time evolution. Cerebral blood flow (CBF) and apparent diffusion coefficient (ADC) maps were reconstructed from 3D-ASL and DWI, respectively. Further, cerebral metabolic rate of oxygen (CMRO2) was calculated as the product of CBF and OEF. OEF, CMRO2, CBF, and ADC values in the ischemic cores (absolute values) and their contrasts to the contralateral regions (relative values) were evaluated. One-way analysis of variance (ANOVA) was used to compare OEF, CMRO2, CBF, and ADC values and their relative values among different stroke stages. The OEF value of infarct core showed a trend of decrease from acute, to early subacute, and to late subacute stages of ischemic stroke. Significant differences among the three stroke stages were only observed in the absolute OEF (F = 6.046, p = 0.005) and relative OEF (F = 5.699, p = 0.009) values of the ischemic core, but not in other measurements (absolute and relative CMRO2, CBF, ADC values, all values of p > 0.05). In conclusion, the challenge-free QSM + qBOLD-generated OEF mapping can be performed on stroke patients. It can provide more information on tissue viability that was not available with CBF and ADC and, thus, may help to better manage ischemic stroke patients. |
topic |
ischemic stroke MRI oxygen extraction fraction cerebral metabolic rate of oxygen quantitative susceptibility mapping cerebral blood flow |
url |
https://www.frontiersin.org/article/10.3389/fnins.2020.535441/full |
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