Combination of Erythromycin and Curcumin Alleviates Staphylococcus aureus Induced Osteomyelitis in Rats
Osteomyelitis is commonly caused by Staphylococcus aureus. Both erythromycin and curcumin can suppress S. aureus growth, but their roles in osteomyelitis are barely studied. We aim to explore the activities of erythromycin and curcumin against chronical osteomyelitis induced by methicillin-resistant...
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doaj-022e5cf787264c81aa53ad5ba34fe0492020-11-25T00:02:46ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882017-08-01710.3389/fcimb.2017.00379286209Combination of Erythromycin and Curcumin Alleviates Staphylococcus aureus Induced Osteomyelitis in RatsZubin ZhouChenhao PanYe LuYoushui GaoWei LiuPeipei YinXiaowei YuOsteomyelitis is commonly caused by Staphylococcus aureus. Both erythromycin and curcumin can suppress S. aureus growth, but their roles in osteomyelitis are barely studied. We aim to explore the activities of erythromycin and curcumin against chronical osteomyelitis induced by methicillin-resistant S. aureus (MRSA). Chronicle implant-induced osteomyelitis was established by MRSA infection in male Wistar rats. Four weeks after bacterial inoculation, rats received no treatment, erythromycin monotherapy, curcumin monotherapy, or erythromycin plus curcumin twice daily for 2 weeks. Bacterial levels, bone infection status, inflammatory signals and side effects were evaluated. Rats tolerated all treatments well, with no death or side effects such as, diarrhea and weight loss. Two days after treatment completion, erythromycin monotherapy did not suppress bacterial growth and had no effect in bone infection, although it reduced serum pro-inflammatory cytokines tumor necrosis factor (TNF)-α and interleukin (IL)-6. Curcumin monotherapy slightly suppressed bacterial growth, alleviated bone infection and reduced TNF-α and IL-6. Erythromycin and curcumin combined treatment markedly suppressed bacterial growth, substantially alleviated bone infection and reduced TNF-α and IL-6. Combination of erythromycin and curcumin lead a much stronger efficiency against MRSA induced osteomyelitis in rats than monotherapy. Our study suggests that erythromycin and curcumin could be a new combination for treating MRSA induced osteomyelitis.http://journal.frontiersin.org/article/10.3389/fcimb.2017.00379/fullStaphylococcus aureusosteomyelitiserythromycincurcumininflammation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zubin Zhou Chenhao Pan Ye Lu Youshui Gao Wei Liu Peipei Yin Xiaowei Yu |
spellingShingle |
Zubin Zhou Chenhao Pan Ye Lu Youshui Gao Wei Liu Peipei Yin Xiaowei Yu Combination of Erythromycin and Curcumin Alleviates Staphylococcus aureus Induced Osteomyelitis in Rats Frontiers in Cellular and Infection Microbiology Staphylococcus aureus osteomyelitis erythromycin curcumin inflammation |
author_facet |
Zubin Zhou Chenhao Pan Ye Lu Youshui Gao Wei Liu Peipei Yin Xiaowei Yu |
author_sort |
Zubin Zhou |
title |
Combination of Erythromycin and Curcumin Alleviates Staphylococcus aureus Induced Osteomyelitis in Rats |
title_short |
Combination of Erythromycin and Curcumin Alleviates Staphylococcus aureus Induced Osteomyelitis in Rats |
title_full |
Combination of Erythromycin and Curcumin Alleviates Staphylococcus aureus Induced Osteomyelitis in Rats |
title_fullStr |
Combination of Erythromycin and Curcumin Alleviates Staphylococcus aureus Induced Osteomyelitis in Rats |
title_full_unstemmed |
Combination of Erythromycin and Curcumin Alleviates Staphylococcus aureus Induced Osteomyelitis in Rats |
title_sort |
combination of erythromycin and curcumin alleviates staphylococcus aureus induced osteomyelitis in rats |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular and Infection Microbiology |
issn |
2235-2988 |
publishDate |
2017-08-01 |
description |
Osteomyelitis is commonly caused by Staphylococcus aureus. Both erythromycin and curcumin can suppress S. aureus growth, but their roles in osteomyelitis are barely studied. We aim to explore the activities of erythromycin and curcumin against chronical osteomyelitis induced by methicillin-resistant S. aureus (MRSA). Chronicle implant-induced osteomyelitis was established by MRSA infection in male Wistar rats. Four weeks after bacterial inoculation, rats received no treatment, erythromycin monotherapy, curcumin monotherapy, or erythromycin plus curcumin twice daily for 2 weeks. Bacterial levels, bone infection status, inflammatory signals and side effects were evaluated. Rats tolerated all treatments well, with no death or side effects such as, diarrhea and weight loss. Two days after treatment completion, erythromycin monotherapy did not suppress bacterial growth and had no effect in bone infection, although it reduced serum pro-inflammatory cytokines tumor necrosis factor (TNF)-α and interleukin (IL)-6. Curcumin monotherapy slightly suppressed bacterial growth, alleviated bone infection and reduced TNF-α and IL-6. Erythromycin and curcumin combined treatment markedly suppressed bacterial growth, substantially alleviated bone infection and reduced TNF-α and IL-6. Combination of erythromycin and curcumin lead a much stronger efficiency against MRSA induced osteomyelitis in rats than monotherapy. Our study suggests that erythromycin and curcumin could be a new combination for treating MRSA induced osteomyelitis. |
topic |
Staphylococcus aureus osteomyelitis erythromycin curcumin inflammation |
url |
http://journal.frontiersin.org/article/10.3389/fcimb.2017.00379/full |
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