Oligodendrogenesis after Cerebral Ischaemia and Traumatic Brain Injury

Oligodendrogenesis after Cerebral Ischaemia and Traumatic Brain Injury

Stroke and traumatic brain injury (TBI) damage white and grey matter. Loss of oligodendrocytes and their myelin, impairs axonal function. Remyelination involves oligodendrogenesis during which new myelinating oligodendrocytes are generated by differentiated oligodendrocyte progenitor cells (OPCs). T...

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Bibliographic Details
Main Authors: Zheng Gang Zhang, Michael Chop
Format: Article
Language:English
Published: European Medical Journal 2013-08-01
Series:European Medical Journal Neurology
Subjects:
Cerebral Ischaemia
Myelination
Oligodendrocyte Progenitor Cells
Oligodendrocytes
Online Access:http://emjreviews.com/wp-content/uploads/Oligodendrogenesis-after-Cerebral-Ischaemia-and-Traumatic-Brain-Injury.pdf
Description
Summary:Stroke and traumatic brain injury (TBI) damage white and grey matter. Loss of oligodendrocytes and their myelin, impairs axonal function. Remyelination involves oligodendrogenesis during which new myelinating oligodendrocytes are generated by differentiated oligodendrocyte progenitor cells (OPCs). This article briefly reviews the processes of oligodendrogenesis in adult rodent brains, and promising experimental therapies targeting the neurovascular unit that reduce oligodendrocyte damage and amplify endogenous oligodendrogenesis after stroke and TBI.
ISSN:2054-4529

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