Oligodendrogenesis after Cerebral Ischaemia and Traumatic Brain Injury

Oligodendrogenesis after Cerebral Ischaemia and Traumatic Brain Injury

Stroke and traumatic brain injury (TBI) damage white and grey matter. Loss of oligodendrocytes and their myelin, impairs axonal function. Remyelination involves oligodendrogenesis during which new myelinating oligodendrocytes are generated by differentiated oligodendrocyte progenitor cells (OPCs). T...

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Bibliographic Details
Main Authors: Zheng Gang Zhang, Michael Chop
Format: Article
Language:English
Published: European Medical Journal 2013-08-01
Series:European Medical Journal Neurology
Subjects:
Cerebral Ischaemia
Myelination
Oligodendrocyte Progenitor Cells
Oligodendrocytes
Online Access:http://emjreviews.com/wp-content/uploads/Oligodendrogenesis-after-Cerebral-Ischaemia-and-Traumatic-Brain-Injury.pdf
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spelling doaj-02384fc3731a4c51b93772e46d6375fd2020-11-25T00:47:10ZengEuropean Medical JournalEuropean Medical Journal Neurology2054-45292013-08-01112631Oligodendrogenesis after Cerebral Ischaemia and Traumatic Brain InjuryZheng Gang Zhang0Michael Chop1Department of Neurology, Henry Ford Hospital, Detroit, Michigan, USADepartment of Neurology, Henry Ford Hospital, Detroit, Michigan, USA. Department of Physics, Oakland University, Rochester, Michigan, USAStroke and traumatic brain injury (TBI) damage white and grey matter. Loss of oligodendrocytes and their myelin, impairs axonal function. Remyelination involves oligodendrogenesis during which new myelinating oligodendrocytes are generated by differentiated oligodendrocyte progenitor cells (OPCs). This article briefly reviews the processes of oligodendrogenesis in adult rodent brains, and promising experimental therapies targeting the neurovascular unit that reduce oligodendrocyte damage and amplify endogenous oligodendrogenesis after stroke and TBI.http://emjreviews.com/wp-content/uploads/Oligodendrogenesis-after-Cerebral-Ischaemia-and-Traumatic-Brain-Injury.pdfCerebral IschaemiaMyelinationOligodendrocyte Progenitor CellsOligodendrocytes
collection DOAJ
language English
format Article
sources DOAJ
author Zheng Gang Zhang
Michael Chop
spellingShingle Zheng Gang Zhang
Michael Chop
Oligodendrogenesis after Cerebral Ischaemia and Traumatic Brain Injury
European Medical Journal Neurology
Cerebral Ischaemia
Myelination
Oligodendrocyte Progenitor Cells
Oligodendrocytes
author_facet Zheng Gang Zhang
Michael Chop
author_sort Zheng Gang Zhang
title Oligodendrogenesis after Cerebral Ischaemia and Traumatic Brain Injury
title_short Oligodendrogenesis after Cerebral Ischaemia and Traumatic Brain Injury
title_full Oligodendrogenesis after Cerebral Ischaemia and Traumatic Brain Injury
title_fullStr Oligodendrogenesis after Cerebral Ischaemia and Traumatic Brain Injury
title_full_unstemmed Oligodendrogenesis after Cerebral Ischaemia and Traumatic Brain Injury
title_sort oligodendrogenesis after cerebral ischaemia and traumatic brain injury
publisher European Medical Journal
series European Medical Journal Neurology
issn 2054-4529
publishDate 2013-08-01
description Stroke and traumatic brain injury (TBI) damage white and grey matter. Loss of oligodendrocytes and their myelin, impairs axonal function. Remyelination involves oligodendrogenesis during which new myelinating oligodendrocytes are generated by differentiated oligodendrocyte progenitor cells (OPCs). This article briefly reviews the processes of oligodendrogenesis in adult rodent brains, and promising experimental therapies targeting the neurovascular unit that reduce oligodendrocyte damage and amplify endogenous oligodendrogenesis after stroke and TBI.
topic Cerebral Ischaemia
Myelination
Oligodendrocyte Progenitor Cells
Oligodendrocytes
url http://emjreviews.com/wp-content/uploads/Oligodendrogenesis-after-Cerebral-Ischaemia-and-Traumatic-Brain-Injury.pdf
work_keys_str_mv AT zhenggangzhang oligodendrogenesisaftercerebralischaemiaandtraumaticbraininjury
AT michaelchop oligodendrogenesisaftercerebralischaemiaandtraumaticbraininjury
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