Immunoglobulin E-Mediated Autoimmunity

The study of autoimmunity mediated by immunoglobulin E (IgE) autoantibodies, which may be termed autoallergy, is in its infancy. It is now recognized that systemic lupus erythematosus, bullous pemphigoid (BP), and chronic urticaria, both spontaneous and inducible, are most likely to be mediated, at...

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Main Authors: Marcus Maurer, Sabine Altrichter, Oliver Schmetzer, Jörg Scheffel, Martin K. Church, Martin Metz
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00689/full
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spelling doaj-02431981f6bc4011aee6d53ce0525c212020-11-24T23:47:31ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-04-01910.3389/fimmu.2018.00689359991Immunoglobulin E-Mediated AutoimmunityMarcus MaurerSabine AltrichterOliver SchmetzerJörg ScheffelMartin K. ChurchMartin MetzThe study of autoimmunity mediated by immunoglobulin E (IgE) autoantibodies, which may be termed autoallergy, is in its infancy. It is now recognized that systemic lupus erythematosus, bullous pemphigoid (BP), and chronic urticaria, both spontaneous and inducible, are most likely to be mediated, at least in part, by IgE autoantibodies. The situation in other conditions, such as autoimmune uveitis, rheumatoid arthritis, hyperthyroid Graves’ disease, autoimmune pancreatitis, and even asthma, is far less clear but evidence for autoallergy is accumulating. To be certain of an autoallergic mechanism, it is necessary to identify both IgE autoantibodies and their targets as has been done with the transmembrane protein BP180 and the intracellular protein BP230 in BP and IL-24 in chronic spontaneous urticaria. Also, IgE-targeted therapies, such as anti-IgE, must have been shown to be of benefit to patients as has been done with both of these conditions. This comprehensive review of the literature on IgE-mediated autoallergy focuses on three related questions. What do we know about the prevalence of IgE autoantibodies and their targets in different diseases? What do we know about the relevance of IgE autoantibodies in different diseases? What do we know about the cellular and molecular effects of IgE autoantibodies? In addition to providing answers to these questions, based on a broad review of the literature, we outline the current gaps of knowledge in our understanding of IgE autoantibodies and describe approaches to address them.http://journal.frontiersin.org/article/10.3389/fimmu.2018.00689/fullimmunoglobulin E-mediated autoimmunityautoallergyurticariabullous pemphigoidimmunoglobulin E-mechanisms
collection DOAJ
language English
format Article
sources DOAJ
author Marcus Maurer
Sabine Altrichter
Oliver Schmetzer
Jörg Scheffel
Martin K. Church
Martin Metz
spellingShingle Marcus Maurer
Sabine Altrichter
Oliver Schmetzer
Jörg Scheffel
Martin K. Church
Martin Metz
Immunoglobulin E-Mediated Autoimmunity
Frontiers in Immunology
immunoglobulin E-mediated autoimmunity
autoallergy
urticaria
bullous pemphigoid
immunoglobulin E-mechanisms
author_facet Marcus Maurer
Sabine Altrichter
Oliver Schmetzer
Jörg Scheffel
Martin K. Church
Martin Metz
author_sort Marcus Maurer
title Immunoglobulin E-Mediated Autoimmunity
title_short Immunoglobulin E-Mediated Autoimmunity
title_full Immunoglobulin E-Mediated Autoimmunity
title_fullStr Immunoglobulin E-Mediated Autoimmunity
title_full_unstemmed Immunoglobulin E-Mediated Autoimmunity
title_sort immunoglobulin e-mediated autoimmunity
publisher Frontiers Media S.A.
series Frontiers in Immunology
issn 1664-3224
publishDate 2018-04-01
description The study of autoimmunity mediated by immunoglobulin E (IgE) autoantibodies, which may be termed autoallergy, is in its infancy. It is now recognized that systemic lupus erythematosus, bullous pemphigoid (BP), and chronic urticaria, both spontaneous and inducible, are most likely to be mediated, at least in part, by IgE autoantibodies. The situation in other conditions, such as autoimmune uveitis, rheumatoid arthritis, hyperthyroid Graves’ disease, autoimmune pancreatitis, and even asthma, is far less clear but evidence for autoallergy is accumulating. To be certain of an autoallergic mechanism, it is necessary to identify both IgE autoantibodies and their targets as has been done with the transmembrane protein BP180 and the intracellular protein BP230 in BP and IL-24 in chronic spontaneous urticaria. Also, IgE-targeted therapies, such as anti-IgE, must have been shown to be of benefit to patients as has been done with both of these conditions. This comprehensive review of the literature on IgE-mediated autoallergy focuses on three related questions. What do we know about the prevalence of IgE autoantibodies and their targets in different diseases? What do we know about the relevance of IgE autoantibodies in different diseases? What do we know about the cellular and molecular effects of IgE autoantibodies? In addition to providing answers to these questions, based on a broad review of the literature, we outline the current gaps of knowledge in our understanding of IgE autoantibodies and describe approaches to address them.
topic immunoglobulin E-mediated autoimmunity
autoallergy
urticaria
bullous pemphigoid
immunoglobulin E-mechanisms
url http://journal.frontiersin.org/article/10.3389/fimmu.2018.00689/full
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AT sabinealtrichter immunoglobulinemediatedautoimmunity
AT oliverschmetzer immunoglobulinemediatedautoimmunity
AT jorgscheffel immunoglobulinemediatedautoimmunity
AT martinkchurch immunoglobulinemediatedautoimmunity
AT martinmetz immunoglobulinemediatedautoimmunity
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