Association Between Impairment of DNA Double Strand Break Repair and Decreased Ovarian Reserve in Patients With Endometriosis

Association Between Impairment of DNA Double Strand Break Repair and Decreased Ovarian Reserve in Patients With Endometriosis

Background: Repair of DNA double strand break (DSB) is an important mechanism for maintaining genetic stability during a DNA damage event. Although, a growing body of recent evidence suggests that DNA DSBs and related repair mechanisms may be important in ovarian aging and in various cancers, there...

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Main Authors: Young Sik Choi, Ji Hyun Park, Jae Hoon Lee, Jeong-Kee Yoon, Bo Hyon Yun, Joo Hyun Park, Seok Kyo Seo, Hak-Joon Sung, Hyun-Soo Kim, SiHyun Cho, Byung Seok Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Endocrinology
Subjects:
endometriosis
ovarian reserve
double stranded DNA break
BRCA1 gene
gamma-H2AX
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00772/full

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